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RISS 인기검색어
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- 저자 : Mohammad Reza Salahshoor (검색결과 4 건)
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Genistein improve nicotine toxicity on male mice pancreas
Mohammad Reza Salahshoor,Fatemeh Mirzaei,Shiva Roshankhah,Parnian Jalili,Cyrus Jalili 대한해부학회 2019 Anatomy & Cell Biology Vol.52 No.2
Nicotine is the most toxic factor of tobacco. Genistein is a phytoestrogen and antioxidant that has numerous health benefits. The aim of this study is to evaluate the effects of genistein against toxic properties of nicotine to the pancreas of mice. For this purpose, 48 male mice were randomly assigned into six groups (n=8): normal control, nicotine control (2.5mg/kg), genistein (25 and 50 mg/kg), and nicotine+genistein (25 and 50 mg/kg) treated groups. Various doses of genistein and genistein+nicotine were administered intraperitoneally to animals for 4 weeks. The weight of pancreas, total antioxidant capacity and nitrite oxide of serum, insulin levels, and the number and diameter of islets of Langerhans were investigated. Nicotine administration reduced significantly total antioxidant capacity, insulin, pancreas weight, and the number and diameter of islets of Langerhans and increased nitrite oxide in serum compared to the control normal group (P<0.05). Conversely, genistein and genistein+nicotine increased significantly insulin, total antioxidant capacity, and the number and diameter islets of Langerhans and decreased serum nitrite oxide compared to the nicotine control group. It seems that the genistein can improve pancreas damage following the nicotine administration.
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Reza Sobhani Ahmadgurabi,Mohammad Ali Nekoui,Karim Salahshoor 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10
Predictive controller based on model has been known as a reliable and robust controller in the last 20 years. This paper presents a new idea of design and implementing an adaptive model predictive controller on an industrial "dynamic" and "nonlinear" plant in an integrated software environment using Hysys and Matlab packages. The model predictive controller formation is based on an adaptive state-space prediction model of the system response to obtain the control action by minimizing an objective function. The designed MPC controller is utilized to regulate a gaseous industrial plant, simulated in Hysys. The objective of controlling the plant is to compensate for the pressure variations in topside output of the vessel in on-line form. In this paper, the opening value percentage (OP) of a valve in the output is randomly excited in a given interval to identify the output pressure in the plant, called as Process Variable (PV). The predicted and desired outputs are then employed in the designed model predictive controller to determine the control actions in the prediction horizon. The simulation results obtained in the developed integrated Hysys-Matlab environment, demonstrate the capability of the proposed approach to efficiently monitor and control an industrial gaseous plant in a real and practical manner.
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Malek Ghanavati,Karim Salahshoor,Mohammad Reza Jahed Motlagh,Amin Ramazani,Ali Moarefianpour 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.2
Nowadays, there is a great interest in using active control methods to increase the compressor working range. The advantage of this controlling method is that the performance point can be located in the vicinity of maximum pressure and efficiency. However, most of the existing controllers require an awareness of compressor characteristic, disturbance upper bound, throttle gain, and throttle valve feature; this is why they are limited in engineering applications. In order to overcome the weakness of the existing controllers, this research employs a novel combined controlling method based on robust adaptive control, which is designed using backstepping technique because the compressor behavior is nonlinear. The increased efficiency and improved operational area for the compressor are provided by this controller without requiring any knowledge or information regarding the compressor characteristic, disturbance upper bound, throttle gain, and throttle valve feature. The adaptive controller has been used to compensate for uncertainties of the compressor characteristic and throttle valve as well as the un-modeled dynamics. Also, the controller robustness is a barrier against the time-varying disturbances in flow and pressure applied to the system. Finally, simulation results showed that the designed controller, in addition to assure the system stability, developed the compressor working range, and the convergence of system states was achieved after applying disturbance in flow and pressure.
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Ahmad Shabanizadeh,Shiva Roshankhah,Amir Abdolmaleki,Mohammad Reza Salahshoor 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.3
Solanum melongena green calyx (SMGC) with antioxidant features seems to have many therapeutic features. Diabetes mellitus (DM) is a blood sugar disorder that increases oxidative stress levels in various types of cells leading to testopathy. In this study we aimed to investigate the protective functions of hydro-alcoholic extract of SMGC on DM‐induced testicular damages. Mature male rats were randomly divided into five groups (n = 8); 1: control, 2: diabetic, 3: diabetic + 100 mg/kg of SMGC, 4: diabetic + 300 mg/kg of SMGC, and 5: diabetic + 500 mg/kg of SMGC. Intraperitoneal injection of streptozotocin (STZ, a single dose of 60 mg/kg) was used for DM induction. Testicular alterations were evaluated quantitatively based on stereological techniques and followed by antioxidant enzymes determination (catalase, superoxide dismutase, and glutathione peroxidase), and serum testosterone level. Malondialdehyde and Bcl‐2 protein expression were also assessed biochemically. DM caused significant harmful changes in testicular structure, inhibition of antioxidant enzymes activity, decreased testosterone levels, and increased lipid peroxidation (LP). The expression of Bcl‐2 protein was down-regulated in DM testis along with boosted apoptosis rate. Eight weeks of SMGC treatment (particularly in high doses) recovered structural variations significantly, restored the power of the antioxidant defense system, and modified the testosterone levels. These findings revealed that the SMGC is considered as an effective antioxidant agent to decrease the adverse effects of DM on male reproductive system.
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