Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum

Hosseini, Sare,Bananzadeh, Ali Mohammad,Mohammadianpanah, Mohammad,Salek, Roham,Taghizadeh-Kermani, Ali The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.1

Purpose: Local recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate the potential role of adjuvant radiation therapy on oncologic outcomes of patients with adenocarcinoma of the cecum. Materials and Methods: This retrospective study was carried out at three large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of 162 patients with adenocarcinoma of the cecum that were treated and followed up between 2000 and 2013. All the patients had undergone a right hemicolectomy and received chemotherapy with (n = 48) or without (n = 114) adjuvant radiation therapy. Results: The subjects were 65 females and 97 males with a median age of 56 years (range, 17 to 90 years) at diagnosis. The 5-year local control (LC), disease free survival (DFS), and overall survival (OS) rates were 72.7%, 57.2%, and 62.6% respectively. In a multivariate analysis, age, tumor stage, node stage, and adjuvant radiation therapy were determined to be independent prognostic factors. Age more than 55 years (hazard ratio [HR] = 1.0; 95% confidence interval [CI], 0.06-0.32; p = 0.003), T4 stage (HR = 6.8; 95% CI, 3.07-15.36; p < 0.001), node positive disease (HR = 4.2; 95% CI, 1.94-9.13; p < 0.001), and the absence of adjuvant radiation therapy (HR = 3.0; 95% CI, 1.39-6.46; p = 0.005) had a negative influence on OS. Conclusion: Adjuvant radiation therapy significantly improves DFS and OS in patients with adenocarcinoma of the cecum.

Aeroelastic analysis of cantilever non-symmetric FG sandwich plates under yawed supersonic flow

Mohammad Hosseini,Ali Ghorbanpour Arani,Mohammad Reza Karamizadeh,Hassan Afshari,Shahriar Niknejad 한국풍공학회 2019 Wind and Structures, An International Journal (WAS Vol.29 No.6

In this paper, a numerical solution is presented for supersonic flutter analysis of cantilever non-symmetric functionally graded (FG) sandwich plates. The plate is considered to be composed of two different functionally graded face sheets and an isotropic homogeneous core made of ceramic. Based on the first order shear deformation theory (FSDT) and linear piston theory, the set of governing equations and boundary conditions are derived. Dimensionless form of the governing equations and boundary conditions are derived and solved numerically using generalized differential quadrature method (GDQM) and critical velocity and flutter frequencies are calculated. For various values of the yaw angle, effect of different parameters like aspect ratio, thickness of the plate, power law indices and thickness of the core on the flutter boundaries are investigated. Numerical examples show that wings and tail fins with larger length and shorter width are more stable in supersonic flights. It is concluded for FG sandwich plates made of Al-Al2O3 that increase in volume fraction of ceramic (Al2O3) increases aeroelastic stability of the plate. Presented study confirms that improvement of aeroelastic behavior and weight of wings and tail fins of aircrafts are not consistent items. It is shown that value of the critical yaw angle depends on aspect ratio of the plate and other parameters including thickness and variation of properties have no considerable effect on it. Results of this paper can be used in design and analysis of wing and tail fin of supersonic airplanes.

Prognostic significance of adjuvant radiation therapy in adenocarcinoma of the cecum

Sare Hosseini,Ali Mohammad Bananzadeh,Mohammad Mohammadianpanah,Roham Salek,Ali Taghizadeh-Kermani 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.1

Purpose: Local recurrence is a common failure pattern in adenocarcinoma of the cecum. This study aimed to investigate the potential role of adjuvant radiation therapy on oncologic outcomes of patients with adenocarcinoma of the cecum. Materials and Methods: This retrospective study was carried out at three large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of 162 patients with adenocarcinoma of the cecum that were treated and followed up between 2000 and 2013. All the patients had undergone a right hemicolectomy and received chemotherapy with (n = 48) or without (n = 114) adjuvant radiation therapy. Results: The subjects were 65 females and 97 males with a median age of 56 years (range, 17 to 90 years) at diagnosis. The 5-year local control (LC), disease free survival (DFS), and overall survival (OS) rates were 72.7%, 57.2%, and 62.6% respectively. In a multivariate analysis, age, tumor stage, node stage, and adjuvant radiation therapy were determined to be independent prognostic factors. Age more than 55 years (hazard ratio [HR] = 1.0; 95% confidence interval [CI], 0.06–0.32; p = 0.003), T4 stage (HR = 6.8; 95% CI, 3.07–15.36; p < 0.001), node positive disease (HR = 4.2; 95% CI, 1.94–9.13; p < 0.001), and the absence of adjuvant radiation therapy (HR = 3.0; 95% CI, 1.39–6.46; p = 0.005) had a negative influence on OS. Conclusion: Adjuvant radiation therapy significantly improves DFS and OS in patients with adenocarcinoma of the cecum.

Prognostic Significance of Mucinous Histologic Subtype on Oncologic Outcomes in Patients With Colorectal Cancer

Sare Hosseini,Ali Mohammad Bananzadeh,Roham Salek,Mohammad Zare-Bandamiri,Ali Taghizadeh Kermani,Mohammad Mohammadianpanah 대한대장항문학회 2017 Annals of Coloproctolgy Vol.33 No.2

Purpose: Mucinous adenocarcinomas account for about 10% of all colorectal cancers. This study aimed to investigate the prognostic impact of mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer. Methods: This retrospective study was performed at two large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of patients with colorectal cancer who were treated and followed up between 2000 and 2013. Results: Totally, 144 of 1,268 patients with a colorectal adenocarcinoma (11.4%) had mucinous histologic subtype. Statistically significant results found in this research are as follows: Mucinous histologic subtype tended to present in younger patients and to have larger tumor size, higher histologic grade, higher node stage, larger number of positive nodes, and higher rate of perineural invasion compared to nonmucinous histologic subtype. On the univariate analysis, mucinous subtype was a prognostic factor for disease-free and overall survival. On the multivariate analysis, primary tumor location, node stage and lymphatic-vascular invasion were independent prognostic factors for the local control rate. Rectal tumor location, higher disease stage, tumor grade II, and presence of lymphatic-vascular invasion had negative influences on disease-free survival, as did rectal tumor location, higher disease stage and presence of lymphatic-vascular invasion on overall survival. Conclusion: Mucinous histologic subtype was associated with some adverse pathologic features in patients with colorectal cancer; however, it was not an independent prognostic factor for oncologic outcome.

No Detection of Xenotropic Murine Leukemia Virus-Related Viruses in Prostate Cancer in Sanandaj, West of Iran

Khodabandehloo, Mazaher,Hosseini, Weria,Rahmani, Mohammad-Reza,Rezaee, Mohammad-Ali,Hakhamaneshi, Mohammad-Saied,Nikkhoo, Bahram,Jalili, Ali Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Background: Multiple etiologies have been hypothesized for prostate cancer, including genetic defects and infectious agents. A recently reported gamaretrovirus, xenotropic murine leukemia virus-related virus (XMRV) has been reported to be detected in prostate cancer. However, this virus has not been detected in similar groups of patients in other studies. Herein, we sought to detect XMRV in prostate cancers and benign controls in Sanandaj, west of Iran. Materials and Methods: In a case-control study, genomic DNA was extracted from formalin fixed and paraffin embedded prostate tissues from a total of 163 Iranian patients. We developed a conventional and a nested PCR assay using primers targeting to an env specific sequence of XMRV. PCR assays were carried out on 63 prostate cancers and 100 benign prostate hyperplasias. Results: Beta-actin sequences were successfully detected in the DNA extracts from all prostate tissues, confirming DNA extraction integrity. We did not detect XMRV in samples either from prostate cancers or benign prostate hyperplasias using XMRV specific primers. Conclusions: We conclude that in our population XMRV does not play a role in genesis of prostate cancer.

Genetic diversity of Iranian wild barley (Hordeum spontaneum Koch.) populations

Hosseini Mojtaba,Yassaie Mohsen,Rashed-Mohassel Mohammad Hassan,Ghorbani Reza,Niazi Ali 한국작물학회 2022 Journal of crop science and biotechnology Vol.25 No.3

An efective weed management program requires a comprehensive knowledge of a weed’s genetic diversity. Wild barley (Hordeum spontaneum Koch) is known as an invasive weed that is rising in commercial cereal felds of Iran. Genetic diversity of 31 populations of Iranian wild barley consisting of 27 populations from Fars province along with four collected from Alborz, Kermanshah, Khuzestan, and Lorestan provinces was investigated using 15 ISSR markers. Cluster analysis showed that populations were divided into six main groups based on 88.5% similarity level. According to PCoA results, seven groups were determined based on populations’ data. The maximum similarity is recorded between Fasa and Darab populations (95.6%) and the minimum was noted between Sepidan and Mohr (78.6%). Genetic variation within the investigated wild barley populations (53%) was higher than between populations (47%). Results of Mantel test revealed a correlation between population distance and latitude, rainfall, annual temperature, and population geographic distances. Generally, latitudes, annual mean temperature, and annual mean rainfall are infuenced by genetic diversity of wild barley in Iran.

A Reliability-based Methodology for Considering Corrosion Effects on Fatigue Deterioration in Steel Bridges - Part II: Case Study of Neka Bridge -

Ali Sahrapeyma,Mohammad S. Marefat,Abdollah Hosseini 한국강구조학회 2013 International Journal of Steel Structures Vol.13 No.4

The methodology presented in Part I is examined on Neka Bridge, a railway, truss bridge in northern Iran. The study includes:considerations of climate and air pollution, extraction of the stress-time histories from the FE model, prediction of future trafficvolumes in a probabilistic manner and assessment of the effects of MR&R actions on the deterioration profile. PDF of D isdetermined using Monte Carlo simulations, and the reliability profile is calculated from the performance function. The studyshows that for a target reliability of 2.0, the fatigue life of the bridge is reduced by either 29% or 31% if dose-response functionor qualitative-based y-t function is used, respectively.

Life-cycle Prediction of Steel Bridges using Reliability-based Fatigue Deterioration Profile: Case Study of Neka Bridge

Ali Sahrapeyma,Abdollah Hosseini,Mohammad S. Marefat 한국강구조학회 2013 International Journal of Steel Structures Vol.13 No.2

Fatigue deterioration profiles of critical elements in a railway truss bridge are determined using a probabilistic approach. A performance function including fatigue strength, R, and fatigue action, D, is used, where R is a material property with lognormal distribution. The random variable D depends on AASHTO category, stress spectrum and traffic features. By applying Monte-Carlo simulations on the performance function of each year, reliability index profile is calculated. The reliability profile decreases with life, and whenever reaches to a critical value, an MR&R action should be implemented. A numerical approach is presented to specify the effects of MR&R actions on the deterioration profile. These actions include re-welding, attaching CFRP and combination of them. The structural model is calibrated by results of a loading test. In addition, the uncertainties arisen from future traffic volume and the relevant S-N curve are considered by a statistical analysis. For a target reliability of 2.0, the retrofit time for deck and truss are estimated. Finally, the outputs of the research are used to recommend a plan for maintenance of Neka Bridge.

Modeling potential habitats for Pergularia tomentosa using maximum entropy model and effect of environmental variables on its quantitative characteristics in arid rangelands, southeastern Iran

Hosseini, Seyed Hamzeh,Azarnivand, Hossein,Ayyari, Mahdi,Chahooki, Mohammad Ali Zare,Erfanzadeh, Reza,Piacente, Sonia,Kheirandish, Reza The Ecological Society of Korea 2018 Journal of Ecology and Environment Vol.42 No.4

Background: Predicting the potential habitat of plants in arid regions, especially for medicinal ones, is very important. Although Pergularia tomentosa is a key species for medicinal purposes, it appears in very low density in the arid rangelands of Iran, needing an urgent ecological attention. In this study, we modeled and predicted the potential habitat of P. tomentosa using maximum entropy, and the effects of environmental factors (geology, geomorphology, altitude, and soil properties) on some characteristics of the species were determined. Results: The results showed that P. tomentosa was absent in igneous formation while it appeared in conglomerate formation. In addition, among geomorphological units, the best quantitative characteristics of P. tomentosa was belonged to the conglomerate formation-small hill area (plant aerial parts = 57.63 and root length = 30.68 cm) with the highest electrical conductivity, silt, and $CaCO_3$ content. Conversely, the species was not found in the mountainous area with igneous formation. Moreover, plant density, length of roots, and aerial parts of the species were negatively correlated with soil sand, while positive correlation was observed with $CaCO_3$, EC, potassium, and silt content. The maximum entropy was found to be a reliable method (ROC = 0.91) for predicting suitable habitats for P. tomentosa. Conclusion: These results suggest that in evaluating the plant's habitat suitability in arid regions, contrary to the importance of the topography, some environmental variables such as geomorphology and geology can play the main role in rangeland plants' habitat suitability.

Magneto-thermo-elastic response of a rotating functionally graded cylinder

Mohammad Hosseini,Ali Dini 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.56 No.1

In this paper, an analytical solution of displacement, strain and stress field for rotating thick-walled cylinder made of functionally graded material subjected to the uniform external magnetic field and thermal field in plane strain state has been studied. Stress, strain and displacement field as a function of radial coordinates considering magneto-thermo-elasticity are derived analytically. According to the Maxwell electro-dynamic equations, Lorentz force in term of displacement is obtained in cylindrical coordinates. Also, symmetric temperature distribution along the thickness of hollow cylinder is obtained by solving Fourier heat transfer equation in cylindrical coordinates. Using equation of equilibrium and thermo-mechanical constitutive equations associated with Lorentz force, a second-order inhomogeneous differential equation in term of displacement is obtained and will be solved analytically. Except Poisson's ratio, other mechanical properties such as elasticity modulus, density, magnetic permeability coefficient, heat conduction coefficient and thermal expansion coefficient are assumed to vary through the thickness according to a power law. In results analysis, non-homogeneity parameter has been chosen arbitrary and inner and outer surface of cylinder are assumed to be rich metal and rich ceramic, respectively. The effect of rotation, thermal, magnetic field and non-homogeneity parameter of functionally graded material which indicates percentages of cylinder's constituents are studied on displacement, Von Mises equivalent stress and Von Mises equivalent strain fields.