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RISS 인기검색어
- 검색키워드
- 저자 : Mohamed A. Ghareeb (검색결과 5 건)
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Ghareeb Doaa A.,Saleh Samar R.,Seadawy Mohamed G.,Nofal Mohammed S.,Abdulmalek Shaymaa A.,Hassan Salma. F.,Khedr Shaimaa M.,AbdElwahab Miral G.,Sobhy Ahmed A.,Abdel-Hamid Ali saber Ali,Yassin Abdelrah 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.6
Purpose A novel coronavirus (COVID-19) that has not been previously identified in humans and has no specific treatment has recently spread. Treatment trials using antiviral and immune-modulating drugs such as hydroxychloroquine (HCQ) were used to control this viral outbreak however several side effects have emerged. Berberine (BER) is an alkaloid that has been reported to reveal some pharmacological properties including antioxidant and antimicrobial activities. Additionally, Zinc oxide nanoparticles (ZnO-NPs) possess potent antioxidant and anti-inflammatory properties. Therefore, this study was undertaken to estimate the efficiency of both BER and synthetic ZnO/BER complex as an anti-COVID-19 therapy. Methods First, the ZnO/BER complex was prepared by the facile mixing method. Then in vitro studies on the two compounds were conducted including VeroE6 toxicity, anti-COVID-19 activity, determination of inhibitory activity towards papain-like proteinase (PL pro) and spike protein- and receptor- binding domain (RBD) as well as assessment of drug toxicity on RBCs. Results The results showed that ZnO/BER complex acts as an anti-COVID-19 by inhibiting spike protein binding with angiotensin-converting enzyme II (ACE II), PL pro activity, spike protein and E protein levels, and expression of both E-gene and RNA dependent RNA polymerase (RdRp) at a concentration lower than that of BER or ZnO-NPs alone. Furthermore, ZnO/BER complex had antioxidant and antimicrobial properties where it prevents the auto oxidation of 2,2-Diphenyl- 1-picrylhydrazyl (DPPH) and the culture of lower respiratory system bacteria that affected Covid 19 patients. The ZnO/BER complex prevented as well the HCQ cytotoxic effect on both RBC and WBC (in vitro) and hepatotoxicity, nephrotoxicity and anemia that occurred after HCQ long administration in vivo. Conclusion The ZnO/BER complex can be accounted as promising anti-COVID 19 candidate because it inhibited the virus entry, replication, and assembly. Furthermore, it could be used to treat a second bacterial infection that took place in hospitalized COVID 19 patients. Moreover, ZnO/BER complex was found to eliminate the toxicity of long-term administration of HCQ in vivo.
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Potential therapeutic and pharmacological strategies for SARS-CoV2
Ghareeb Doaa A.,Saleh Samar R.,Nofal Mohammed S.,Kaddah Mohamed M. Y.,Hassan Salma. F.,Seif Inas K.,El-Zahaby Sally A.,Khedr Shaimaa M.,Kenawy Marwa Y.,Masoud Aliaa A.,Soudi Salma A.,Sobhy Ahmed A.,Se 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.3
Background At the end of 2019, the new Coronavirus disease 2019 (COVID-19) strain causing severe acute respiratory syndrome swept the world. From November 2019 till February 2021, this virus infected nearly 104 million, with more than two million deaths and about 25 million active cases. This has prompted scientists to discover effective drugs to combat this pandemic. Area covered Drug repurposing is the magic bullet for treating severe acute respiratory syndrome coronavirus 2 (SARSCoV2). Therefore, several drugs have been investigated in silico, in vitro, as well as through human trials such as anti- SARS-CoV2 agents, or to prevent the complications resulting from the virus. In this review, the mechanisms of action of different therapeutic strategies are summarized. According to the WHO, different classes of drugs can be used, including anti-malarial, antiviral, anti-inflammatory, and anti-coagulant drugs, as well as angiotensin-converting enzyme inhibitors, antibiotics, vitamins, zinc, neutralizing antibodies, and convalescent plasma therapy. Recently, there are some vaccines which are approved against SARS-CoV2. Expert opinion A complete understanding of the structure and function of all viral proteins that play a fundamental role in viral infection, which contribute to the therapeutic intervention and the development of vaccine in order to reduce the mortality rate.
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Generalized Double Fuzzy Semi-Basically Disconnected Spaces
Mohammed, Fatimah M.,Noorani, Mohd Salmi Md.,Ghareeb, A. Korean Institute of Intelligent Systems 2014 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.14 No.3
In this paper, we introduce the concept of generalized double fuzzy semi-basically disconnected space and related notions such as (r, s)-generalized fuzzy semiopen-$F_{\sigma}$ sets, (r, s)-generalized fuzzy semiclosed-$G_{\delta}$ sets, generalized double fuzzy $semi^*$-open function, generalized double fuzzy $semi^*$-continuous function and generalized double fuzzy $semi^*$-irresolute function. Some interesting properties and characterizations of the concepts introduced are studied.
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Generalized Double Fuzzy Semi-Basically Disconnected Spaces
Fatimah M. Mohammed,M. S. M. Noorani,A. Ghareeb 한국지능시스템학회 2014 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.14 No.3
In this paper, we introduce the concept of generalized double fuzzy semi-basically disconnected space and related notions such as (r, s)-generalized fuzzy semiopen-Fσ sets, (r, s)-generalized fuzzy semiclosed-Gδ sets, generalized double fuzzy semi<SUP>*</SUP>-open function, generalized double fuzzy semi<SUP>*</SUP>-continuous function and generalized double fuzzy semi<SUP>*</SUP>-irresolute function. Some interesting properties and characterizations of the concepts introduced are studied.
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Effectiveness of dredging and drains’ treatment on water quality of Rosetta branch
Mohie Eldin M. Omar,Mohamed A. Ghareeb,Shaimaa El Sherbini 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.1
Rosetta Branch of Nile River in Egypt receives drainage water from five agricultural drains deteriorating its water quality. Since the branch is used for irrigation and municipal purposes, its water quality should be enhanced. Hence, the current paper aimed at providing the most effective intervention to improve the branch water quality. Preventing drainage disposal was excluded due its significance to downstream users. The paper investigated the impacts of drains" treatment and branch dredging on hydrodynamics and water quality. The branch was numerically simulated using HECRAS model, and calibrated using measured water levels and quality parameters. The paper selected constructed wetlands as the most suitable method for drainage treatment based on conditions of study area. SUBWET model predicted optimal designs of wetlands achieving the desired treatment efficiency. SUBWET model was calibrated with experimental wetlands at Delta Barrage. Results showed that 1-m dredging dropped water surface elevations by 22 to 50 cm. Dredging had no significant changes in the backwater zone of Edfina Barrage at the branch end except for the maximum flow case. Simulation of dissolved oxygen and ammonium showed that dredging and treatment improved water quality. Drains’ treatment by constructed wetlands with selected designs was much more effective than dredging.
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