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서민준(Minjun Seo),박진한(Jinhan Park),이제현(Jehyun Lee),정지욱(Jiwook Jung) 한국한의학연구원 2011 한국한의학연구원논문집 Vol.17 No.1
Objective : In the present study, we assessed the enhancing effect of the fermented Angelicae Gigantis Radix on memory and cognitive function in scopolamine induced amnesia mice. Method : The memory and cognitive enhancing effect of the fermented Angelicae Gigantis Radix was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine. Result : The fermented Angelicae Gigantis Radix significantily reversed the scopolamine-induced cognitive impairments in the passive avoidance test. Moreover, the fermented Angelicae Gigantis Radix also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze. On the Y-maze test, fermented Angelicae Gigantis Radix also significantily reversed the scopolamine-induced cognitive impairments in mice. Conclusion : The fermented Angelicae Gigantis Radix possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and these activities were parallel to treatment duration and dependent on the learning models.
서민준(Minjun Seo),이규봉(Kyubong Lee),박진한(Jinhan Park),홍승헌(Seungheon Hong) 한국한의학연구원 2010 한국한의학연구원논문집 Vol.16 No.2
Objective : The purpose of this study was to provide the information about Bojungikki-tang by domestic papers and theses. Method : Domestic papers related to Bojungikki-tang were reviewed and analyzed. These papers were classified by year, research method, experimental method, and subject. Result : The following results were obtained in this study. 1. The study of Bojungikki-tang started from 1984 and continued steadily. 2. The domestic papers about Bojungikki-tang were 47 volumes. Among them, there were 26 volumes since 2000. 3. Classified by research method from the year 2000, 20 experimental studies, 4 clinical experiments, and 2 documentary researches. 4. Classified by experimental method from the year 2000, 10 studies used mouse in vivo experiment and 4 studies used rat in vivo experiment and 6 studies used each cell in vitro experiment. 5. Classified by subject from the year 2000, papers related to immune enhancing effect, nerve and mental system, radiation protection effect, anti-allergy, anti-inflammatory, anti-cancer, remedy of diabetes, skin protection and so on. Conclusion : Many papers of experimental studies, clinical experiments and documentary researches related Bojungikki-tang are included in domestic journals. Bojungikki-tang is being researched variously in immune enhancing effect, nerve and mental system, radiation protection effect, anti-allergy, anti-inflammatory, anti-cancer, remedy of diabetes, skin protection and so on. However, more clinical studies on Bojungikki-tang are needed.
Minjun KIM,Seon-Gyeong KIM,Yena SEO,Yedam CHOI,Tae-Jong KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Staphylococcus aureus causes various infections such as endocarditis and pneumonia, and the number of its infection is increasing in recent years. Infections caused by multidrug-resistant bacteria, such as methicillin-resistant S. aureus (MRSA), are difficult to cure with conventional antibiotics alone. The use of high-dose antibiotics leads to the emergence of more resistant strains. In this study, we propose the use of antibiotics together with natural compounds that increase the effectiveness of antibiotics in order to treat antibiotic-resistant bacterial infections and reduce the amount of antibiotics used. Colony-forming units of MRSA were significantly reduced when treated together with concentrations of Ricini Semen and oxacillin that did not affect growth. Ricinoleic acid, the main compounds in Ricini Semen, has enhanced antibiotic activity of oxacillin. S. aureus can incorporate extracellular fatty acidsinto the cell membrane. To identify the relationship between the composition of membrane fatty acids and the increased antibiotic activity of oxacillin, the change in the composition of membrane fatty acids after treatment with ricinoleic acid and oxacillin will be analyzed.
Seo, Youngrok,Moon, Donghyun,Lee, Changho,Park, Jeong-Woo,Kim, Byeong-Soo,Lee, Gang-Woo,Dotel, Pratik,Lee, Jong-Won,Cha, Minjun,Yoon, Ji-Ho American Chemical Society 2015 Environmental science & technology Vol.49 No.10
<P>Many studies have focused on desalination via hydrate formation; however, for their potential application, knowledge pertaining to thermodynamic stability, formation kinetics, and guest occupation behavior in clathrate hydrates needs to be determined. Herein, the phase equilibria of SF<SUB>6</SUB> hydrates in the presence of NaCl solutions (0, 2, 4, and 10 wt %) were monitored in the temperature range of 277–286 K and under pressures of up to 1.4 MPa. The formation kinetics of SF<SUB>6</SUB> hydrates in the presence of NaCl solutions (0, 2, and 4 wt %) was also investigated. Gas consumption curves of SF<SUB>6</SUB> hydrates showed that a pure SF<SUB>6</SUB> hydrate system allowed fast hydrate growth as well as high conversion yield, whereas SF<SUB>6</SUB> hydrate in the presence of NaCl solutions showed retarded hydrate growth rate as well as low conversion yield. In addition, structural identification of SF<SUB>6</SUB> hydrates with and without NaCl solutions was performed using spectroscopic tools such as Raman spectroscopy and X-ray diffraction. The Raman spectrometer was also used to evaluate the temperature-dependent release behavior of guest molecules in SF<SUB>6</SUB> and SF<SUB>6</SUB> + 4 wt % NaCl hydrates. The results indicate that whereas SF<SUB>6</SUB> hydrate starts to decompose at around 240 K, the escape of SF<SUB>6</SUB> molecules in SF<SUB>6</SUB> + 4 wt % NaCl hydrate is initiated rapidly at around 205 K. The results of this study can provide a better understanding of guest–host interaction in electrolyte-containing systems.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2015/esthag.2015.49.issue-10/acs.est.5b00866/production/images/medium/es-2015-00866w_0007.gif'></P>