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        Cocktail Formula and Application Prospects for Oral and Maxillofacial Organoids

        Ou Mingyu,Li Qing,Ling Xiaofang,Yao Jinguang,Mo Xiaoqiang 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.5

        Oral and maxillofacial organoids (OMOs), tiny tissues and organs derived from stem cells cultured through 3-d cell culture models, can fully summarize the cell tissue structure, physiological functions and biological characteristics of the source tissues in the body. OMOs are applied in areas such as disease modelling, developmental and regenerative medicine, drug screening, personalized treatment, etc. Although the construction of organoids in various parts of the oral and maxillofacial (OM) region has achieved considerable success, the existing cocktail formulae (construction strategies) are not widely applicable for tissues of various sources due to factors including the heterogeneity of the source tissues and the dependence on laboratory technology. Most of their formulae are based on growth factor niches containing expensive recombinant proteins with their efficiency remaining to be improved. In view of this, the cocktail formulae of various parts of the OM organs are reviewed with further discussion of the application and prospects for those OMOs to find some affordable cocktail formula with strong operability and high repeatability for various maxillofacial organs. The results may help improve the efficiency of organoid construction in the laboratory and accelerate the pace of the clinical use of organoid technology.

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        Design of a Fresnel Lens for a Solar End-pumped Solid-state Laser

        Mingyu Ou,Pian Hu,Lanling Lan,Yan Liu,Jun Zhou,Xiaotao Shi 한국광학회 2020 Current Optics and Photonics Vol.4 No.5

        A novel design for a Fresnel lens for a solar end-pumped laser is demonstrated in this paper. The new hybrid Fresnel lens includes two parts, inner and outer. The inner part is a twice-total-internal-reflection and vertical-transmission lens. The outer part is a once-total-reflection and vertical-transmission lens. The radius of the Fresnel lens is 600 mm, and its focal length is 750 mm. The concentrating performance of the Fresnel lens is examined using TracePro. The results show that the concentration efficiency has been greatly improved. The total concentration efficiency of the hybrid Fresnel lens reaches 73.2% when the radius of the laser rod is 3 mm. This design can simplify the concentration system of a solar endpumped solid-state laser.

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