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- 저자 : Xiaotao Shi (검색결과 3 건)
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Chen Wei,Wang Siying,Shi Xiaotao,Rheem Chang-Kyu,Lin Yongshui,Liu Erpeng 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1
The Vortex-Induced Vibration (VIV) of a circular cylinder with different surface roughness is numerically simulated at a subcritical Reynolds number of 3900. The effects of surface roughness on the vibration response amplitude, hydrodynamic coefficients and wake vortex are analyzed. The results show that as surface roughness increases, four branches (initial, upper, super-upper and lower branches) appear in the VIV response for a smooth cylinder, and for a cylinder with a small surface roughness of KS=D ¼ 2:5 103 , this response changes to three branches (initial, upper and lower branches). The vortex shedding for the initial and lower branches is 2S mode, and that for the upper and super-upper branches (lock-in range) is P þ S, PþSþ and 2P modes. With increasing surface roughness, the maximum amplitude has little difference, and the width of the lock-in range increases. A large jump in the vortex phase at the transition of the initial and upper branches and a large jump in the total lift phase at the transition of the upper and lower branches are found, and these jumps are associated with a switch in the timing of vortex shedding (jump of the vortex phase: 2S mode to P þ S mode; jump of the lift phase: other modes to 2S mode). The results are significant for the development of flow and vibration control technology.
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Design of a Fresnel Lens for a Solar End-pumped Solid-state Laser
Mingyu Ou,Pian Hu,Lanling Lan,Yan Liu,Jun Zhou,Xiaotao Shi 한국광학회 2020 Current Optics and Photonics Vol.4 No.5
A novel design for a Fresnel lens for a solar end-pumped laser is demonstrated in this paper. The new hybrid Fresnel lens includes two parts, inner and outer. The inner part is a twice-total-internal-reflection and vertical-transmission lens. The outer part is a once-total-reflection and vertical-transmission lens. The radius of the Fresnel lens is 600 mm, and its focal length is 750 mm. The concentrating performance of the Fresnel lens is examined using TracePro. The results show that the concentration efficiency has been greatly improved. The total concentration efficiency of the hybrid Fresnel lens reaches 73.2% when the radius of the laser rod is 3 mm. This design can simplify the concentration system of a solar endpumped solid-state laser.
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Lineage conversion of mouse fibroblasts to pancreatic α-cells
Lijian Hui,Liangliang Sun,Beige Jiang,Limei Li,Jin Cen,Xiaotao Chen,Zhaoyun Zhang,Qinghua Wang,Xin Cheng,Yongquan Shi,Lijian Hui 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
α-cells, which synthesize glucagon, also support β-cell survival and have the capacity to transdifferentiate into β-cells. However, the role of α-cells in pathological conditions and their putative clinical applications remain elusive due in large part to the lack of mature α-cells. Here, we present a new technique to generate functional α-like cells. α-like cells (iAlpha cells) were generated from mouse fibroblasts by transduction of transcription factors, including Hhex, Foxa3, Gata4, Pdx1 and Pax4, which induce α-cell-specific gene expression and glucagon secretion in response to KCl and Arg stimulation. The cell functions in vivo and in vitro were evaluated. Lineage-specific and functional-related gene expression was tested by realtime PCR, insulin tolerance test (ITT), glucose tolerance test (GTT), Ki67 and glucagon immunohistochemistry analysis were done in iAlpha cells transplanted nude mice. iAlpha cells possess α-cell function in vitro and alter blood glucose levels in vivo. Transplantation of iAlpha cells into nude mice resulted in insulin resistance and increased β-cell proliferation. Taken together, we present a novel strategy to generate functional α-like cells for the purposes of disease modeling and regenerative medicine.
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