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Huifang Zhang,Mingliang Pei,Peng Liu 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
PK-SS-Hy-D drug-protein prodrug was obtained by conjugating doxorubicin (DOX) onto the PEGylatedkeratin (PK) with both bioreducible disulfide linkage and acid-cleavable hydrazone bond in a seriesconnection mode. The controlled release profiles demonstrated the pH and reduction dual-responsivetriggered release of DOX from the proposed drug-protein conjugate nanoparticles, with a low prematuredrug leakage of 5.5% in the simulated physiological medium. The in vitro experiments indicated that theproposed prodrug nanoparticles could delivery DOX into the cell nuclei, with an enhanced anti-tumorefficacy. It is expected as a potential candidate for future tumor chemotherapy with minimized toxic sideeffect.