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      • SCOPUSKCI등재SCIE

        Evidence integration on health damage for humidifier disinfectant exposure and legal presumption of causation

        Mina Ha(Mina Ha),Taehyun Park(Taehyun Park),Jong-Hyun Lee(Jong-Hyun Lee),Younghee Kim(Younghee Kim),Jungyun Lim(Jungyun Lim),Yong-Wook Baek(Yong-Wook Baek),Sol Yu(Sol Yu),Hyen-Mi Chung(Hyen-Mi Chung) 한국역학회 2023 Epidemiology and Health Vol.45 No.-

        OBJECTIVES: Inhalation exposure to humidifier disinfectants has resulted to various types of health damages in Korea. To determine the epidemiological correlation necessary for presuming the legal causation, we aimed to develop a method to synthesize the entire evidence. METHODS: Epidemiological and toxicological studies are systematically reviewed. Target health problems are selected by criteria such as frequent complaints of claimants. Relevant epidemiologic studies are reviewed and the risk of bias and confidence level of the total evidence are evaluated. Toxicological literature reviews are conducted on three lines of evidence including hazard information, animal studies, and mechanistic studies, considering the source-to-exposure-to-outcome continuum. The confidence level of the body of evidence is then translated into the toxicological evidence levels for the causality between humidifier disinfectant exposure and health effects. Finally, the levels of epidemiological and toxicological evidence are synthesized. RESULTS: Under the Special Act revised in 2020, if the history of exposure and the disease occurred/worsened after exposure were approved, and the epidemiological correlation between the exposure and disease was verified, the legal causation is presumed unless the company proves the evidence against it. The epidemiological correlation can be verified through epidemiological investigations, health monitoring, cohort investigations and/or toxicological studies. It is not simply as statistical association as understood in judicial precedents, but a general causation established by the evidence as a whole, i.e., through weight-of-the-evidence approach. CONCLUSIONS: The weight-of-the-evidence approach differs from the conclusive single study approach and this systematic evidence integration can be used in presumption of causation.

      • Correlation of Breast Cancer Incidence with the Number of Motor Vehicles and Consumption of Gasoline in Korea

        Park, Boyoung,Shin, Aesun,Jung-Choi, Kyunghee,Ha, Eunhee,Cheong, Hae-Kwan,Kim, Hyun Jeong,Park, Kyung Hwa,Jang, Sungmi,Moon, Byung-In,Ha, Mina Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

        While several reproductive and lifestyle-related factors are already well-known as established risk factors for breast cancer, environmental factors have attracted attention only recently. The objective of the current study was to assess the association between the breast cancer incidences in females, the mortality rate and the number of motor vehicles on the one side and the consumption of gasoline which could work as a major source of air pollution at the other side. The breast cancer incidences and the mortality trends were compared with various indices of westernization like dietary patterns or industrialization with 10 years lag of time. Geographical variations with 10, 15 and 20 years lag of time were assessed between the breast cancer incidence in 2010 and the number of motor vehicles as well as the consumption of gasoline. The upward trend of motor vehicle numbers proved to be comparable to those of breast cancer incidence and mortality. However, the consumption of gasoline started to decrease since the mid-1990s. The geographic distribution of motor vehicle numbers and gasoline consumption in 1990 is in a positive correlation with the breast cancer incidence rates in 2010 and the 20-year lag time ($R^2$ 0.379 with the number of motor vehicles and 0.345 with consumption of gasoline). In a linear relationship between the breast cancer incidences in 2010 and the log transformed number of motor vehicles, the log transformed consumption of gasoline in 2000 also showed a positive relationship ($R^2$ 0.367 with the number of motor vehicles and 0.329 with consumption of gasoline). The results of the current study indicate that there may be a positive relation between the number of vehicles, gasoline consumption and the incidence of breast cancer from the aspects of long-term trends and geographical variation.

      • KCI등재

        Clinical Outcomes of Renal Pelvis Dilatation in Very Low Birth Weight Infants

        ( Mina Jeon ),( Juhyun Jin ),( Jeong Eun Shin ),( Soon Min Lee ),( Ho Seon Eun ),( Min Soo Park ),( Kook In Park ),( Ran Namgung ) 대한주산의학회 2016 大韓周産醫學會雜誌 Vol.27 No.4

        Purpose: The aim of this study was to evaluate this clinical outcome of neonatal pelvis dilatation in very low birth weight (VLBW) infants. Methods: The medical records of 127 VLBW infants admitted to two neonatal intensive care units from January 2012 to December 2014 were retrospectively analyzed. Renal pelvis dilatation was diagnosed via ultrasound examination with cases divided into 3 groups: mild (dilatation of 5-10 mm), moderate (11-15 mm) and severe (≥15 mm). The correlation between the 3 dilatation groups and progression into hydronephrosis was evaluated. Results: Among the 127 premature infants, renal pelvis dilatation was identified in 29 (22.8%) on ultrasound examination performed, on average 13.3 days after birth, combined with calyceal ectasia in 5 (3.9%) infants. At a postmenstrual age of 40 weeks, 18 infants (14.2%) had renal pelvis dilatation, 6 (5%) infants accompanied by a dilatation of the calyx. On the last follow-up performed when children were not older than 2 years old, renal pelvis dilatation had resolved to within normal limits in 23 (79%) infants while persisting in 6 (21%) infants; 1 mild, 3 moderate, and 2 severe pelvis dilatation. The median time-to-recovery of dilatation was 10.5 months (Kaplan-Meier curve), regardless of the severity of dilatation at birth. Based on receiver operating curve analysis, a cutoff diameter of renal dilatation at birth of 11.35 mm predicted persisting severe dilatation at the final follow-up (sensitivity 83.3%, specificity 82.6%). Conclusion: Although premature infants with dilatation of mild severity were all recovered, some of those with moderate-to-severe dilatation progressed to hydronephrosis. Therefore careful follow-up of premature infants with renal pelvis dilatation is recommended.

      • KCI등재

        Effect of Vitamin D on the Treatment of Atopic Dermatitis With Consideration of Heterogeneities: Meta-Analysis of Randomized Controlled Trials

        Park Ji Soo,Kim Mina,Sol In Suk,Lee Kyung Suk,Park Suyeon,Yang Hyeon-Jong,Lee Eun 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.2

        Various therapeutic approaches, including supplemental nutritional support, have been tried for the treatment of atopic dermatitis (AD). Previous studies have reported the role of vitamin D in the treatment of AD with inconsistent results. The aim of this study was to evaluate the effectiveness of vitamin D in the treatment of AD, with considerations on the heterogeneities of AD. Randomized controlled trials (RCTs) on the efficacy of vitamin D supplementation for AD treatment, published before June 30, 2021 were identified in the PubMed, EMBASE, MEDLINE, and Cochrane Library databases. The quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation system. This meta-analysis included 5 RCTs with 304 cases of AD. We found that vitamin D supplementation did not decrease AD severity, even when AD was classified as severe vs non-severe. However, vitamin D supplementation was found to be effective in the treatment of AD in RCTs that included both children and adults, but not in those that included only children. Geographic location was associated with a significant difference in the therapeutic effect of vitamin D supplementation. Moreover, vitamin D supplementation of > 2,000 IU/day decreased AD severity, but supplementation ≤ 2,000 IU/day did not. Vitamin D supplementation, in general, was not effective for the treatment of AD. However, vitamin D supplementation might provide a therapeutic effect depending on the geographic location and dose of supplementation. The results of the present meta-analysis suggest that vitamin D supplementation might be targeted for patients with AD who may benefit from vitamin D supplementation.

      • KCI등재

        Effects of etomidate use in ICU patients on ventilator therapy: a study of 12,526 patients in an open database from a single center

        Park Ha Yeon,이윤석,임지연,Kim Mina,Park Ji Eun,Lee Teakseon 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.4

        Background: There is a debate regarding the safety of etomidate. We evaluated the effects of etomidate on mortality in a large cohort of critical care patients.Methods: This retrospective matched-cohort study was performed using the Medical Information Mart for Intensive Care version 3 (MIMIC-III) database. Among 12,526 adult patients who were prescribed etomidate or propofol on the first day of mechanical ventilation, 625 patients administered etomidate were statistically matched with 6,250 patients administered propofol. The primary outcome measures were all-cause in-hospital mortality, 48-hour survival, cardiovascular morbidity, and infectious morbidity. Logistic regression analysis with stepwise selection of variables was performed to examine the dose–mortality relationship of etomidate.Results: All-cause in-hospital mortality was 1.84 times higher in the etomidate cohort (OR, 1.84; 98.75% CI, 1.42, 2.37). Compared to the propofol cohort, the etomidate cohort showed 57% lower odds of 48-hour survival (0.43 [0.27, 0.73]), no difference in odds of cardiovascular morbidity (0.86 [0.66, 1.12]), and 1.77 times higher odds of infectious morbidity (1.77 [1.35, 2.31]). Additionally, the odds of mortality increased by 1.36 times per 0.1 mg/kg of etomidate (1.36 [95% CI: 1.23, 1.49]).Conclusions: Etomidate is a poor choice as a hypnotic drug on the first day of mechanical ventilation, as it is associated with a dose-dependent increase in all-cause mortality, and does not improve survival for the first 48 h.

      • SCISCIESCOPUS
      • A study on the factors affecting the follow-up participation in birth cohorts

        Park, Bohyun,Choi, Eun Jeung,Ha, Eunhee,Choi, Jong Hyuk,Kim, Yangho,Hong, Yun-Chul,Ha, Mina,Park, Hyesook The Korean Society of Environmental Toxicology 2016 환경독성보건학회지 Vol.31 No.-

        Objectives A stable follow-up participation rate is a very important factor for validity in a cohort study. This study analyzed the factors that affect the participation rate at one hospital-based birth cohort in South Korean. Methods The participants were recruited from the Mothers' and Children's Environmental Health study between 2006 and 2010. The analysis targeted 1751 mothers who participated in a birth cohort. We conducted analyses of general characteristics during pregnancy and those of infants at birth that affect the participation rate of the 6-month follow-up survey. Results The participation rate for the 6-month follow-up survey was 60.4%. The participation rate in the follow-up of the subsequent period decreased within a 5% to 10% range compared to the number of subjects. The participation rate of premature infants was 16.9% lower than that of a full-term infant (52.6% vs. 69.5%). Analysis showed a 16.7% difference between the participation rate of low-birthweight infants in follow-ups (53.7%) and the participation rate of infants with normal weight (70.4%). The participation rate of mothers who were employed during pregnancy was significantly lower for the 6-month follow-up compared to the participation rate of mothers who were unemployed during pregnancy. Conclusions In this study, factors such as premature birth, low-birthweight, and the employment status of the mother during pregnancy affected the participation rate of the follow-up survey for the birth cohort at six months. A specific strategy is needed to encourage survey participation for the high risk groups in the follow-ups.

      • Polarized micro-cavity organic light-emitting devices

        Park, Byoungchoo,Kim, Mina,Park, Chan Hyuk The Optical Society 2009 Optics express Vol.17 No.9

        <P>We present the results of a study of light emissions from a polarized micro-cavity Organic Light-Emitting Device (OLED), which consisted of a flexible, anisotropic one-dimensional (1-D) photonic crystal (PC) film substrate. It is shown that luminous Electroluminescent (EL) emissions from the polarized micro-cavity OLED were produced at relatively low operating voltages. It was also found that the peak wavelengths of the emitted EL light corresponded to the two split eigen modes of the high-energy band edges of the anisotropic PC film, with a strong dependence on the polarization state of the emitting light. For polarization along the ordinary axis of the anisotropic PC film, the optical split micro-cavity modes occurred at the longer high-energy photonic band gap (PBG) edge, while for polarization along the extraordinary axis, the split micro-cavity modes occurred at the shorter high-energy PBG edge, with narrow bandwidths. We demonstrated that the polarization and emission mode of the micro-cavity OLED may be selected by choosing the appropriate optical axis of the anisotropic 1-D PC film.</P>

      • Polarized organic light-emitting device on a flexible giant birefringent optical reflecting polarizer substrate

        Park, Byoungchoo,Park, Chan Hyuk,Kim, Mina,Han, Mi-young The Optical Society 2009 Optics express Vol.17 No.12

        <P>We present the results of a study of highly linear polarized light emissions from an Organic Light-Emitting Device (OLED) that consisted of a flexible Giant Birefringent Optical (GBO) multilayer polymer reflecting polarizer substrate. Luminous Electroluminescent (EL) emissions over 4,500 cd/m(2) were produced from the polarized OLED with high peak efficiencies in excess of 6 cd/A and 2 lm/W at relatively low operating voltages. The direction of polarization for the emitted EL light corresponded to the passing (ordinary) axis of the GBO-reflecting polarizer. Furthermore, the estimated polarization ratio between the brightness of two linearly polarized EL emissions parallel and perpendicular to the passing axis could be as high as 25 when measured over the whole emitted luminance range.</P>

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