A 3-Gb/s Equalizer with an Adaptive Swing Controller for TFT-LCD Interfaces

Miao-Shan Li,Yen-Chen Lin,Chai-Chi Liu,Ching-Rong Chang,Jyun-Yi Li,You-Sheng Lin,Ching-Yuan Yang 대한전자공학회 2019 Journal of semiconductor technology and science Vol.19 No.1

A 0.18-μm CMOS 3-Gb/s equalizer with an adaptive swing controller is presented for 4K2K large display panels to compensate a 24-dB channel loss. Employing the output-swing control technique, we propose the adaptive loop for the equalizer to improve adaptation accuracy without degrading the boost tuning and input swing ranges. Besides, cascading two bandpass filters (BPF) measured energy in a narrow range is much more accuracy than conventional highpass filters (HPF). The measured jitter of 3-Gb/s and 1.5-Gb/s data are 0.23-UI and 0.356-UI for 1.23-m FR4 board, respectively. The core area occupies 0.12-㎟ and the power consumption is 27-mW at 3 Gb/s from a 1.8-V supply.

DNA Repair Gene Associated with Clinical Outcome of Epithelial Ovarian Cancer Treated with Platinum-based Chemotherapy

Kang, Shan,Sun, Hai-Yan,Zhou, Rong-Miao,Wang, Na,Hu, Pei,Li, Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Objective: The nucleotide excision repair (NER) and base excision repair (BER) pathways, two DNA repair pathways, are related to platinum resistance in cancer treatment. In this paper, we studied the association between single nucleotide polymorphisms (SNPs) of involved genes and response to platinum-based chemotherapy in epithelial ovarian cancer. Method: Eight SNPs in XRCC1 (BER), XPC and XPD (NER) were assessed in 213 patients with epithelial ovarian cancer using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and primer-introduced restriction analysis-polymerase chain reaction (PIRA-PCR) techniques. Results: The median progression-free survival (PFS) of patients carrying the Lys/Lys and Lys/Gln+Gln/Gln genotype of the XPC Lys/Gln polymorphism were 25 and 12 months, respectively (P=0.039); and the mean overall survival (OS) of patients was 31.1 and 27.8 months, respectively (P=0.048). Cox's multivariate analysis suggested that patients with epithelial ovarian cancer with the Gln allele had an increased risk of death (HR=1.75; 95% CI=1.06-2.91) compared to those with the Lys/Lys genotype. There are no associations between the XPC PAT+/-, XRCC1 Arg194Trp, Arg280His, Arg399Gln, and XPD Asp312Asn, Lys751Gln polymorphisms and the survival of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy. Conclusion: Our results indicated that the XPC Lys939Gln polymorphism may correlate with clinical outcome of patients with epithelial ovarian cancer when treated with platinum-based chemotherapy in Northern China.

Improvement and validation of aerosol models for natural deposition mechanism in reactor containment

Jishen Li,Bin Zhang,Pengcheng Gao,Fan Miao,Jianqiang Shan Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7

Nuclear safety is the lifeline for the development and application of nuclear energy. In severe accidents of pressurized water reactor (PWR), aerosols, as the main carrier of fission products, are suspended in the containment vessel, posing a potential threat of radioactive contamination caused by leakage into the environment. The gas-phase aerosols suspended in the containment will settle onto the wall or sump water through the natural deposition mechanism, thereby reducing atmospheric radioactivity. Aiming at the low accuracy of the aerosol model in the ISAA code, this paper improves the natural deposition model of aerosol in the containment. The aerosol dynamic shape factor was introduced to correct the natural deposition rate of non-spherical aerosols. Moreover, the gravity, Brownian diffusion, thermophoresis and diffusiophoresis deposition models were improved. In addition, ABCOVE, AHMED and LACE experiments were selected to validate and evaluate the improved ISAA code. According to the calculation results, the improved model can more accurately simulate the peak aerosol mass and respond to the influence of the containment pressure and temperature on the natural deposition rate of aerosols. At the same time, it can significantly improve the calculation accuracy of the residual mass of aerosols in the containment. The performance of improved ISAA can meet the requirements for analyzing the natural deposition behavior of aerosol in containment of advanced PWRs in severe accident. In the future, further optimization will be made to address the problems found in the current aerosol model.

Study on the influence of flow blockage in severe accident scenario of CAP1400 reactor

Gao Pengcheng,Zhang Bin,Li Jishen,Miao Fan,Tang Shaowei,Cao Sheng,Yang Hao,Shan Jianqiang 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3

Deformed fuel rods can cause a partial blockage of the flow area in a subchannel. Such flow blockage will influence the core coolant flow and further the core heat transfer during the reflooding phase and subsequent severe accidents. Nevertheless, most of the system analysis codes simulate the accident process based on the assumed flow blockage ratio, resulting in inconsistencies between simulated results and actual conditions. This paper aims to study the influence of flow blockage in severe accident scenario of the CAP1400 reactor. First, the flow blockage model of ISAA code is improved based on the FRTMB module. Then, the ISAA-FRTMB coupling system is adopted to model and calculate the QUENCH-LOCA- 0 experiment. The correctness and validity of the flow blockage model are verified by comparing the peak cladding temperature. Finally, the DVI Line-SBLOCA accident is induced to analyze the influence of flow blockage on subsequent CAP1400 reactor core heat transfer and core degradation. From the results of the DVI Line-SBLOCA accident analysis, it can be concluded that the blockage ratio is in the range of 40%e60%, and the position of severe blockage is the same as that of cladding rupture. The blockage reduces the circulation area of the core coolant, which in turn impacts the heat exchange between the core and the coolant, leading to the early failure and collapse of some core assemblies and accelerating the core degradation process.

Effects of enzymolysis and fermentation of Chinese herbal medicines on serum component, egg production, and hormone receptor expression in laying hens

Mei Hong Jiang,Tao Zhang,Qing Ming Wang,Jin Shan Ge,Lu Lu Sun,Meng Qi Li,Qi Yuan Miao,Yuan Zhao Zhu Asian Australasian Association of Animal Productio 2024 Animal Bioscience Vol.37 No.1

Objective: In the present study, we aimed to investigate the effects of enzymolysis fermentation of Chinese herbal medicines (CHMs) on egg production performance, egg quality, lipid metabolism, serum reproductive hormone levels, and the mRNA expression of the ovarian hormone receptor of laying hens in the late-laying stage. Methods: A total of 360 Hy-Line Brown laying hens (age, 390 days) were randomly categorized into four groups. Hens in the control (C) group were fed a basic diet devoid of CHMs, the crushed CHM (CT), fermented CHM (FC), and enzymatically fermented CHM (EFT) groups received diets containing 2% crushed CHM, 2% fermented CHM, and 2% enzymatically fermented CHM, respectively. Results: Compared with crushed CHM, the acid detergent fiber, total flavonoids, and total saponins contents of fermented CHM showed improvement (p<0.05); furthermore, the neutral and acid detergent fiber, total flavonoids, and total saponins contents of enzymatically fermented CHM improved (p<0.05). At 5 to 8 weeks, hens in the FC and EFT groups showed increased laying rates, haugh unit, albumin height, yolk color, shell thickness, and shell strength compared with those in the C group (p<0.05). Compared with the FC group, the laying rate, albumin height, and Shell thickness in the EFT group was increased (p<0.05). Compared with the C, CT, and FC groups, the EFT group showed reduced serum total cholesterol and increased serum luteinizing hormone levels and mRNA expressions of follicle stimulating hormone receptor and luteinizing hormone receptor (p<0.05). Conclusion: These results indicated that the ETF group improved the laying rate and egg quality and regulated the lipid metabolism in aged hens. The mechanism underlying this effect was likely related to cell wall degradation of CHM and increased serum levels of luteinizing hormone and mRNA expression of the ovarian hormone receptor.