Efficacy and Toxicity of Gemcitabine Plus Docetaxel Combination as a Second Line Therapy for Patients with Advanced Stage Soft Tissue Sarcoma

Ali Osman, Kaya,Suleyman, Buyukberber,Metin, Ozkan,Necati, Alkis,Alper, Sevinc,Nuriye Yildirim, Ozdemir,Suleyman, Alici,Onur, Esbah,Veli, Berk,Celalettin, Camci,Arife, Ulas,Ugur, Coskun,Mustafa, Benek Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

Purpose: To assess the safety and efficacy of a gemcitabine plus docetaxel regimen as a second line therapy for patients with advanced soft tissue sarcoma (STS) resistant to doxorubicin and ifosfamide-based therapy. Patients and Methods: Medical records of 64 patients with advanced STS who received gemcitabine plus docetaxel regimen as a second line treatment between May 2006 and June 2011 were examined. All patients had been previously treated with doxorubicin plus ifosfamide-based regimen at first line setting. Patients received gemcitabine 900 $mg/m^2$ on days one and eight intravenously over 90 minutes, followed by docetaxel 75 $mg/m^2$ on day eight intravenously over one hour. Cycles were repeated every 3 weeks. Results: The male-to-female ratio was 37/27 and the median age was 44 years (range; 19-67 years). Objective responses were observed in 13 (20.3 %) patients (2 CR, 11 PR) and stable disease in 21 (32.8 %). Total clinical benefit (CR+PR+SD) was observed in 34 (53.1 %). Median overall survival (OS) was 18 months (95% confidence interval (CI):12.1-23.9) and Median time to progression (TTP) was 4.8 months (95% CI: 3.6-6). A total of 243 cycles of chemotherapy were administered. The median number of cycle was 3 (range;1-11). The most common grade 3-4 hematologic toxicity was neutropenia (35.9 %). The most common nonhematologic toxicities consisted of nausea/vomiting (37.5 %), mucositis (32.8 %), peripheral neuropathy (29.7%), and fatigue (26 %). There was no toxicity-related death. Conclusion: The combination of gemcitabine plus docetaxel is an active and tolerable regimen as a second line therapy for patients with advanced soft tissue sarcoma who have failed doxorubicin and ifosfamide-based therapy.

The effect of sweep angle on the limit cycle oscillations of aircraft wings

Eken, Seher,Kaya, Metin Orhan Techno-Press 2015 Advances in aircraft and spacecraft science Vol.2 No.2

This study focuses on the limit cycle oscillations (LCOs) of cantilever swept-back wings containing a cubic nonlinearity in an incompressible flow. The governing aeroelastic equations of two degrees-of-freedom swept wings are derived through applying the strip theory and unsteady aerodynamics. In order to apply strip theory, mode shapes of the cantilever beam are used. The harmonic balance method is used to calculate the frequencies of LCOs. Linear flutter analysis is conducted for several values of sweep angles to obtain the flutter boundaries.

Free transverse vibrations of an elastically connected simply supported twin pipe system

Müge Balkaya,Metin O. Kaya,Ahmet Sa lamer 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.5

In this paper, free vibration analyses of a parallel placed twin pipe system simulated by simply supported-simply supported and fixed-fixed Euler-Bernoulli beams resting on Winkler elastic soil are presented. The motion of the system is described by a homogenous set of two partial differential equations, which is solved by a simulation method called the Differential Transform Method (DTM). Free vibrations of an elastically connected twin pipe system are realized by synchronous and asynchronous deflections. The results of the presented theoretical analyses for simply supported Euler-Bernoulli beams are compared with existing ones in open literature and very good agreement is demonstrated.

Free transverse vibrations of an elastically connected simply supported twin pipe system

Balkaya, Muge,Kaya, Metin O.,Saglamer, Ahmet Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.5

In this paper, free vibration analyses of a parallel placed twin pipe system simulated by simply supported-simply supported and fixed-fixed Euler-Bernoulli beams resting on Winkler elastic soil are presented. The motion of the system is described by a homogenous set of two partial differential equations, which is solved by a simulation method called the Differential Transform Method (DTM). Free vibrations of an elastically connected twin pipe system are realized by synchronous and asynchronous deflections. The results of the presented theoretical analyses for simply supported Euler-Bernoulli beams are compared with existing ones in open literature and very good agreement is demonstrated.

Swallowing and Aspiration: How Much Is Affected by the Number of Arytenoid Cartilages Remaining After Supracricoid Partial Laryngectomy?

Caner Kılıç,Ümit Tunçel,Metin Kaya,Ela Cömert,Samet Özlügedik 대한이비인후과학회 2017 Clinical and Experimental Otorhinolaryngology Vol.10 No.4

Objectives. The aim of this study was to compare the effect of the presence of one or two arytenoids on early/late period swallowing-aspiration functions. Methods. Supracricoid partial laryngectomy (SCPL) with the diagnosis of laryngeal cancer between 2012 and 2014 were retrospectively evaluated. The patients were categorized into two groups as follows: group I, patients who underwent SCPL with one arytenoid cartilage and group II, patients who underwent SCPL with two arytenoid cartilages. The time of decannulation and oral feeding onset, and swallowing-aspiration functions were evaluated and compared in the early nutritional period, first, and third months. Results. There was no significant correlation between decannulation time and swallowing-aspiration. The aspiration rates in group I and group II were similar and there was no significant difference in oral feeding onset and aspiration grades in the first and third months between both groups. Conclusion. We found similar oncological and functional outcomes in SCPL which protected one or two arytenoid cartilages. Therefore we suggest to be performed one arytenoid cartilage SCPL in selected patients who was advance stage and tumor volume over with larynx cancer.

Serum Chitotriosidase Activity in Pulmonary Tuberculosis: Response to Treatment and Correlations with Clinical Parameters

Gulhan Cakır,Seyfettin Gumus,Ergun Ucar,Hatice Kaya,Ergun Tozkoparan,Emin Ozgur Akgul,Bulent Karaman,Omer Deniz,Ismail Kurt,Metin Ozkan,Hayati Bilgic 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.3

Background: Chitotriosidase is an accepted marker of macrophage activation. In this study, we investigated serum chitotriosidase levels in pulmonary tuberculosis (PTB). Methods: Forth-two patients with PTB and 30 healthy subjects were enrolled in the study. The radiological extent of PTB, radiological sequela after treatment, and the degree of smear positivity were assessed. Chitotriosidase levels were measured by a fluorometric method. Results: The serum chitotriosidase levels of the PTB patients were significantly higher than those of the control subjects (39.73±24.97 vs. 9.63±4.55 nmol/mL/h, P<0.001). After completion of the standard 6-month antituberculous treatment, chitotriosidase levels in PTB patients significantly decreased (10.47±4.54 nmol/mL/h, P<0.001). Chitotriosidase levels correlated significantly with the radiological extent of PTB, degree of smear positivity, and post-treatment radiological sequela score (r=0.439, r=0.449, and r=0.337, respectively). Conclusions: This study demonstrated that serum chitotriosidase levels increase in PTB; therefore, chitotriosidase can be used as a marker of disease activity, severity, and response to treatment. Background: Chitotriosidase is an accepted marker of macrophage activation. In this study, we investigated serum chitotriosidase levels in pulmonary tuberculosis (PTB). Methods: Forth-two patients with PTB and 30 healthy subjects were enrolled in the study. The radiological extent of PTB, radiological sequela after treatment, and the degree of smear positivity were assessed. Chitotriosidase levels were measured by a fluorometric method. Results: The serum chitotriosidase levels of the PTB patients were significantly higher than those of the control subjects (39.73±24.97 vs. 9.63±4.55 nmol/mL/h, P<0.001). After completion of the standard 6-month antituberculous treatment, chitotriosidase levels in PTB patients significantly decreased (10.47±4.54 nmol/mL/h, P<0.001). Chitotriosidase levels correlated significantly with the radiological extent of PTB, degree of smear positivity, and post-treatment radiological sequela score (r=0.439, r=0.449, and r=0.337, respectively). Conclusions: This study demonstrated that serum chitotriosidase levels increase in PTB; therefore, chitotriosidase can be used as a marker of disease activity, severity, and response to treatment.