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Shuai Ji,Yujie Wang,Shikai Gao,Xian Shao,Wei Cui,Yan Du,Mengzhe Guo,Daoquan Tang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
Lots of minor constituents in herbal medicines have shown great potential to devolve into leadcompounds, and their extraction is attracting more and more attention in pharmaceutical industry. Thisstudy provided an example that showed efficient and selective extraction of minor bioactive naturalproducts (prenylatedflavonoids with anti-cancer activities) from an herbal medicine (licorice) using pureionic liquids as green solvents. After investigation of a variety of hydrophobic ionic liquids withultrasonic-assisted extraction, we found that [C8MIM]BF4 (1-octyl-3-methylimidazolium tetrafluor-oborate) was the most effective one for extraction offive representative compounds (isoangustone A,glycycoumarin, licoisoflavanone, licoricidin and glabridin), and solvent to solid ratio, extraction time,extraction temperature and soaking time were then optimized through single-factor experiments andresponse surface methodology. As a result, the established method had significantly higher extractionselectivity than conventional organic solvents, which could be attributed to significant physical change oflicorice microstructures after extraction, as well as strong interactions (especially hydrogen bondinteractions) between [C8MIM]BF4 and prenylatedflavonoids by mechanism study. In addition, 78.92% ofthe extracted prenylatedflavonoids could be readily recovered from [C8MIM]BF4 by using reversed-phasesolid phase extraction, and the recyclability of [C8MIM]BF4 was also confirmed.