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Meng, Li-Juan,Zuo, Hua,Vijaykumar, B.V.D.,Dupati, Gautam,Choi, Kyung-Min,Jang, Kiwan,Yoon, Yong-Jin,Shin, Dong-Soo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
Optically active N-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and N-benzyl-2-methyl-2H-benzo[b][1,4]thiazin-3(4H)-ones with potential synthetic and pharmacological interest were prepared via Smiles rearrangement in conventional as well as microwave irradiation conditions in one-pot from inexpensive (S)-2-chloropropionic acid. Most of the compounds displayed good inhibition against Gram positive bacteria and fungi in the antibiotic test.
Active current-limiting control to handle DC line fault of overhead DC grid
MENG Zhou,WANG Xiang,WENPING Zuo,WEIXING Lin,JINYU Wen,RUIZHANG Yang,BINYE Ni,XIAOJUN Lu 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
To handle with the DC line faults in a DC grid, this paper proposed an active current-limiting controller for hybrid MMC. With this active current-limiting control strategy, the requirement of interruption current of DCCB will be significantly decreased, and the investment of DC grid will be reduced obviously. Firstly, the control architecture of active current-limiting controller is disclosed. To avoid the overvoltage of submodule capacitors during DC fault, a dynamic limiter for the reference value of the DC current controller is proposed. To decrease the peak of fault current, the feedforward controller of DC voltage is put forward. The decoupling controllability of the AC/DC voltage of hybrid MMC is disclosed. The currentlimiting mechanism of the active current-limiting controller is analysis. Then, the validity of the active current-limiting control strategy is verified by RTDS.
Highly Efficient Microwave-assisted Aminolysis of Epoxides in Water
Zuo, Hua,Li, Zhu-Bo,Zhao, Bao-Xiang,Miao, Jun-Ying,Meng, Li-Juan,Jang, Ki-Wan,Ahn, Chul-Jin,Lee, Dong-Ha,Shin, Dong-Soo Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.suppl8
Highly efficient and rapid aminolysis of epoxides with various amines in water under microwave irradiation in the absence of catalyst was developed. Chiral ${\beta}$-amino alcohols were formed in a short time with excellent yields.
Hua, Zuo,Kam, Kyeong-Hee,Kwon, Hee-Jin,Meng, Lijuan,Ahn, Chul-Jin,Won, Tae-Jin,Kim, Tae-Hyun,Reddy, Ch. Raji,Chandrasekhar, S.,Shin, Dong-Soo Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.7
Highly efficient synthesis of substituted benzo[1,4]oxazin-3-ones and pyrido[1,4]oxazin-2-ones under microwave irradiation via Smiles rearrangement is reported. Substituted benzo[1,4]oxazin-3-ones and pyrido[1,4]oxazin-2-ones were obtained by treatment of substituted 2-chlorophenols or 2-chloropyridols with N-substituted 2-chloroacetamide in the presence of potassium carbonate in MeCN and subsequent exposure to cesium carbonate in DMF. All the reactions which take 2-10 hours under conventional condition were completed successfully within a few minutes under microwave irradiation giving moderate to excellent yields.
Highly Efficient Microwave-assisted Aminolysis of Epoxides in Water
Hua Zuo,Zhu-Bo Li,Bao-Xiang Zhao,Jun-Ying Miao,Li-juan Meng,Kiwan Jang,안철진,Dong-Ha Lee,신동수 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.8
Highly efficient and rapid aminolysis of epoxides with various amines in water under microwave irradiation in the absence of catalyst was developed. Chiral β-amino alcohols were formed in a short time with excellent yields.
Why MSN Lost to QQ in China Market?-Different Privacy ProtectionDesign
Zhaoli Meng,Meiyun Zuo 보안공학연구지원센터 2008 International Journal of Security and Its Applicat Vol.2 No.4
International software providers have entered China market in recent years. One typical example is MSN. As an indigenous IT products, QQ provides almost the same functions as MSN and competes with MSN for years. Market survey indicates that QQ dominates the local instance message market. Why QQ could win the battle with MSN in China market? In this paper, we investigate the detailed designs of MSN vs. QQ, focusing in particular on their privacy protection. We find that, in general, users’ privacy concern level is low in China. Users show inclination to be connected with strangers in virtual community. They may trade off certain level of privacy protection to gain the chance of visiting by strangers. Moreover, in the position of control could mitigate users’ privacy concern. Indigenous IT products, such as QQ, understand and leverage users’ behavior. By lowering privacy protection and providing various control tools, QQ successfully caters to the need of young generation in China, which is main Internet users in China. Such results shed light on how to survive in China market for international IT product providers.
( Fei-meng Zheng ),( Wang-bing Chen ),( Tao Qin ),( Li-na Lv ),( Bi Feng ),( Yan-ling Lu ),( Zuo-quan Li ),( Xiao-chao Wang ),( Li-ju Tao ),( Hong-wen Li ),( Shu-you Li ) 생화학분자생물학회(구 한국생화학분자생물학회) 2019 BMB Reports Vol.52 No.9
Lymphoma is one of the most curable types of cancer. However, drug resistance is the main challenge faced in lymphoma treatment. Peroxisomal acyl-CoA oxidase 1 (ACOX1) is the rate-limiting enzyme in fatty acid β-oxidation. Deregulation of ACOX1 has been linked to peroxisomal disorders and carcinogenesis in the liver. Currently, there is no information about the function of ACOX1 in lymphoma. In this study, we found that upregulation of ACOX1 promoted proliferation in lymphoma cells, while downregulation of ACOX1 inhibited proliferation and induced apoptosis. Additionally, overexpression of ACOX1 increased resistance to doxorubicin, while suppression of ACOX1 expression markedly potentiated doxorubicin-induced apoptosis. Interestingly, downregulation of ACOX1 promoted mitochondrial location of Bad, reduced mitochondrial membrane potential and provoked apoptosis by activating caspase-9 and caspase-3 related apoptotic pathway. Overexpression of ACOX1 alleviated doxorubicin-induced activation of caspase-9 and caspase-3 and decrease of mitochondrial membrane potential. Importantly, downregulation of ACOX1 increased p73, but not p53, expression. p73 expression was critical for apoptosis induction induced by ACOX1 downregulation. Also, overexpression of ACOX1 significantly reduced stability of p73 protein thereby reducing p73 expression. Thus, our study indicated that suppression of ACOX1 could be a novel and effective approach for treatment of lymphoma. [BMB Reports 2019; 52(9): 566-571]
Preparation of Self Microemulsion of Ferulic Acid
Jinhui Zuo,Qiang Li,Zeyuan Dong,Hong Meng,Li Li,Yinmao Dong 한국피부과학연구원 2017 아시안뷰티화장품학술지 Vol.15 No.3
목적: 본 연구는 페룰산의 자체 에멀젼을 위한 최적의 포뮬러 및 제조공정을 연구 하기 위한 것이다. 방법: Pseudo three phase diagram방법을 이용하여 각기 다른 계면활성제의 마이크로 에멀젼 영역의 형성 크기에 대한 영향을 연구하고, 또한 SZ-100나노입 자분석기를 이용하여, 계면활성제, 보조계면활성제, 오일의 최적의 비율을 확인하였다. 마지막으로 SZ-100나노입자분석기 및 Zeta 전위 분석기를 이용하여 마이크로 에멀젼의 안정성을 확인하였다. 결과: Pseudo three phase diagram방법과 SZ-100나노입자분석 기를 이용하여 측정한 결과를 종합하여, 최적의 에멀젼 처방비율은 polyoxyethylene castor oil (Cremophor EL):polyethylene glycol 40 (PEG 40):무수에탄올:isopropyl myristate (IPM)=3.15:3.15:1.8:1 이고, 에멀젼의 평균입자크기는 15.5 nm 이며, 이때 마이크로 에 멀젼 체계 수분함량은 90% 이었다. 페롤산의 최대 약물적재량(maximum drug loading)은 5.2% 이며, 에멀젼의 안정성 또한 우수하 다는 것을 확인하였다. 결론: 위와 같은 에멀젼 처방의 연구는 페롤산과 같은 불용성 물질의 수중에서의 용해도를 대폭 증가시킴으 로써, 실제 생산응용 시에 중요한 가치를 가질 것으로 사료된다 Purpose: The optimum formulation and preparation process of ferulic acid self microemulsion was studied. Methods: The effect of different surfactants on the formation of microemulsion area was studied by pseudo three phase diagram method. To determine the best ratio among surfactants, cosurfactant and oil phase, the uniformity and particle size of microemulsion was evaluated by nanoparticle size analyzer. Finally, the stability of microemulsion was measured by nanoparticle size analyzer and zeta potential analyzer. Results: Combined the results of pseudo three phase diagram with particle size distribution, the best ratio of self microemulsion:polyoxyethylene castor oil (Cremophor EL): polyethylene glycol 40 (PEG 40):Ethanol:isopropyl myristate (IPM) is about 3.15:3.15:1.8:1. The average particle size of microemulsion is about 15.5 nm which of system contains about 90% water. The maximum drug loading of ferulic acid was 5.2%, and this self microemulsion formulation has good stability. Conclusion: The formula greatly improves the solubility of insoluble materials like ferulic acid in water and it has guiding significance for the application of the microemulsion in practical production.
Which Instant Messaging System Should I Choose: a Conceptual Model
Zhaoli Meng,Meiyun Zuo,Yanhui Chen 보안공학연구지원센터 2009 International Journal of Hybrid Information Techno Vol.2 No.1
Recent years, China has become one of the biggest market for International IT product giants have entered China market in recent years, such as MSN, Google, eBay, and Yahoo!. All of these products experience fierce competitions from indigenous IT products. Although indigenous IT products provide almost the same function as their international competitors, they dominate the market after passing the phase of imitation. What are the key reasons for their success? In this paper, we compare the detailed designs of MSN vs. QQ. By proposing a conceptual model, we investigate how the different functions of MSN and QQ lead to different users’ adoption intention. The conceptual model is not only helpful for researchers who are keen to investigate the factors which affect IT adoption process, but also shed light on how to understand users behavior and grab the market share for practitioners in China.
Li-juan Meng,Hua Zuo,B. V. D. Vijaykumar,Gautam Dupati,Kyung-Min Choi,장기완,윤용진,신동수 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
Optically active N-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and N-benzyl-2-methyl-2H-benzo [b][1,4]thiazin-3(4H)-ones with potential synthetic and pharmacological interest were prepared via Smiles rearrangement in conventional as well as microwave irradiation conditions in one-pot from inexpensive (S)-2- chloropropionic acid. Most of the compounds displayed good inhibition against Gram positive bacteria and fungi in the antibiotic test.