Genetic Variants at 6p21.1 and 7p15.3 Identified by GWASs of Multiple Cancers and Ovarian Cancer Risk: a Case-control Study in Han Chinese Women

Li, Da-Ke,Han, Jing,Liu, Ji-Bin,Jin, Guang-Fu,Qu, Jun-Wei,Zhu, Meng,Wang, Yan-Ru,Jiang, Jie,Ma, Hong-Xia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

A recent study summarized several published genome-wide association studies (GWASs) of cancer and reported two pleiotropic loci at 6p21.1 and 7p15.3 contributing to multiple cancers including lung cancer, noncardia gastric cancer (NCGC), and esophageal squamous-cell carcinoma (ESCC) in Han Chinese. However, it is not known whether such genetic variants have similar effects on the risk of gynecologic cancers, such as ovarian cancer. Hence, we explored associations between genetic variants in 6p21.1 and 7p15.3 and ovarian cancer risk in Han Chinese women. We performed an independent case-control study by genotyping the two loci (rs2494938 A > G at 6p21.1 and rs2285947 A > G at 7p15.3) in a total of 377 ovarian cancer cases and 1,034 cancer-free controls using TaqMan allelic discrimination assay. We found that rs2285947 at 7p15.3 was significantly associated with risk of ovarian cancer with per allele odds ratio (OR) of 1.33 [95% confidence interval (CI): 1.08-1.64, P=0.008]. However, no significant association was observed between rs2494938 and ovarian cancer risk. Our results showed that rs2285947 at 7p15.3 may also contribute to the development of ovarian cancer in Han Chinese women, further suggesting pleiotropy of 7p15.3 in multiple cancers.

A Method of Combining Scrambling Technology with Error Control Coding to Realize Both Confidentiality and Reliability in Wireless M2M Communication

( Meng Zhang ),( Zhe Wang ),( Meng Han Guo ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.1

In this paper we present a novel method of applying image scrambling technology which belongs to the information hiding field in the error control coding to introduce confidentiality in wireless machine to machine communication. The interleaver in serial concatenated convolutional codes, which is the key module in overcoming burst errors, is deliberately designed with the scrambling function to provide a low error rate for those authorized transceivers. By contrast, the unauthorized transceivers without keys would get so high an error rate that decoding bits could bring little value, thus realizing both the confidentiality and reliability in wireless machine to machine communication.

Four-Stage Framework for Implementing a Chatbot System in Disaster Emergency Operation Data Management: A Flood Disaster Management Case Study

Meng-Han Tsai,Cheng-Hsuan Yang,James Yichu Chen,Shih-Chung Kang 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.2

This research proposes a four-stage consultant framework for applying a chatbot as a data management system. With the advancement of computational power and data storage technology, the increasing amount of data makes the issue of data management difficult to address. Management of a massive amount of data by utilizing chatbots to play the roles of a data manager and a data provider has been extensively studied. Although a chatbot system has been proven to increase the overall efficiency of data management, implementing a chatbot system in a government department remains a challenge, especially in a field with highly complex data. This research presents the authors’ experience of applying a chatbot system in a department of the government of Taiwan for disaster response operations. A four-stage consulting framework comprising 1) existing workflow review, 2) usability evaluation, 3) system improvement, and 4) management plan (EUSM) was thus proposed. After a two-year field test, the authors found that the framework could help the department in clarifying their working process, increase the overall efficiency of the chatbot system, and identify the major issues of introducing the chatbot system.

The RAS Scheduling Algorithm Based on 802.11n WIFI Router

Meng Han,Wenyu Chen,Wei Pi,Wen Li,Ru Zeng 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.11

In order to solve the frame overhead to the influence of frame transmission performance, improve the throughput, lower hybrid scenario user acces delay, improve user (802.11 n) especially the user experience, this paper aimed at different rate of terminal equipment, designs the RAS algorithm, this algorithm through optimizing scheduling, in does not affect user delay at low speed, reduce the high-speed users send time delay.The algorithm is reasonable configuration of channel resources, make full use of the high speed channel rate, rate of various users (especially in high speed rate of users) to improve the user experience .In the Chariot on Atheros9341 chip using TCP service test 802.11 n AP topology network end-to-end delay and throughput, thus the proposed method was verified. The measured results showed that the proposed method can improve the AP client in a high-density environment effective machine capacity, and increase the throughput, reduce the delay.

Oxidation behaviour and residual mechanical properties of carbon/carbon composites

Han Meng,Zhou Chuwei,Silberschmidt Vadim V.,Bi Qinsheng 한국탄소학회 2023 Carbon Letters Vol.33 No.4

Carbon/carbon composites are widely used in re-entry engineering applications thanks to their excellent mechanical properties at high temperatures, but they are easily oxidized in the oxygenated atmosphere. It is important to research their residual mechanical properties influenced by oxidation behaviour, in order to ensure the in-service safety. A microscale degradation model is proposed to predict the oxidation behavior based on the mass conservation and diffusion equations, the derived equivalent steady recession rate of composite is employed to evaluate the residual mechanical properties of the oxidized composite theoretically. A numerical strategy is proposed to investigate the oxidation mechanism of this composite. The differences in the degradation rate between the fiber and the matrix resulted in the steady state and an unchanged shape of the front. Residual mechanical properties of composite with three different domains of oxidation were simulated with a multiscale coupled model. The numerical results demonstrated that the mechanical properties of this composite decreased by 24–32% after oxidation for 30 min at 850 °C. Oxidation also caused the stress redistribution inside components, with the stress concentration diminishing their load-bearing capacity. The local areas of increased stress in the pyrocarbon matrix provided new ways for diffusion of oxygen into the pyrocarbon matrix and fibers.

Associations of MMP-2 21306 C/T and MMP-9 21562 C/T polymorphisms with breast cancer risk among different populations: a meta-analysis

Meng Han,Qingfeng Yang,Kai Feng,Rongping Li,Jia Ren,Liguang Wei 한국유전학회 2017 Genes & Genomics Vol.39 No.3

The meta-analysis aims to investigate association between two matrix metalloproteinases (MMPs) polymorphisms (MMP-2 -1306 C/T and MMP-9 -1562 C/T) and breast cancer risk. Eligible studies were retrieved from relevant databases, based on predefined criteria. Quality assessment was evaluated by Newcastle–Ottawa Scale. Odds ratio (OR) with its 95% confidence interval (CI) was selected as the effect size for the meta-analysis. As a result, 13 studies were included. MMP-2 -1306 C/T polymorphism was not significantly associated with breast cancer risk under all genetic models (P[0.05). However, subgroup analysis stratified by ethnicity showed a significant association between MMP-2 -1306 C/T polymorphism and reduced breast cancer risk in Asian populations under allelic model (OR 0.60, 95% CI 0.39–0.90, P = 0.02) and dominant model (OR 0.55, 95% CI 0.34–0.89, P = 0.02). MMP-9 -1562 C/T polymorphism was significantly related to increased breast cancer risk under allelic model (OR 1.50, 95% CI 1.06–2.12, P = 0.02), additive model (OR 1.45, 95% CI 1.02–2.05, P = 0.04) and recessive model (OR 1.54, 95% CI 1.13–2.12, OR 0.007). A significant association between MMP-9 -1562 C/T polymorphism and increased breast cancer risk in Caucasian was detected under most of the genetic models (P\0.05). MMP-2 -1306 C/T polymorphism might be significantly associated with reduced breast cancer risk in Asian, while MMP-9 -1562 C/T might be closely related to increased breast cancer risk, especially in Caucasian.

SEMA: A Site Equipment Management Assistant for Construction Management

Meng-Han Tsai,Cheng-Hsuan Yang,Chen-Hsuan Wang,I-Tung Yang,Shih-Chung Kang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.3

Collecting construction equipment information such as the site equipment enter and exit date-time, driver's name, type, and quantity is essential in construction management. Most construction projects use paper to record the equipment access history. However, manual recording is always labour-intensive and time-consuming. Therefore, this research aims to develop an assistant system, Site Equipment Management Assistant (SEMA), to automate the site equipment management processes. With the introduction of image recognition and multiple objects tracking technologies, the proposed system can extract equipment-related information from raw videos. SEMA is designed as a chatbot system that contains three major modules: data acquisition, information extraction, and information delivery. A deep learning-based model was first trained to automatically recognize and track construction equipment passing by the site monitor. Information such as equipment entering and exiting date-time, type, and quantity would be extracted and stored in a database. A chatbot interface was developed for users to obtain data from the database through an intuitive and easy-to-use interface. A system evaluation and usability test were conducted. The results showed that the system could effectively improve the construction equipment management process. SEMA can save 60.7% of users' operation time on obtaining related information.

The effect of diabetes and prediabetes on the prevalence, complications and mortality in nonalcoholic fatty liver disease

Cheng Han Ng,Kai En Chan,Yip Han Chin,Rebecca Wenling Zeng,Pei Chen Tsai,Wen Hui Lim,Darren Jun Hao Tan,Chin Meng Khoo,Lay Hoon Goh,Zheng Jye Ling,Anand Kulkarni,Lung-Yi Loey Mak,Daniel Q Huang,Mark C 대한간학회 2022 Clinical and Molecular Hepatology(대한간학회지) Vol.28 No.3

Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is closely associated with diabetes. The cumulative impact of both diseases synergistically increases risk of adverse events. However, present population analysis is predominantly conducted with reference to non-NAFLD individuals and has not yet examined the impact of prediabetes. Hence, we sought to conduct a retrospective analysis on the impact of diabetic status in NAFLD patients, referencing non-diabetic NAFLD individuals. Methods: Data from the National Health and Nutrition Examination Survey 1999–2018 was used. Hepatic steatosis was defined with United States Fatty Liver Index (US-FLI) and FLI at a cut-off of 30 and 60 respectively, in absence of substantial alcohol use. A multivariate generalized linear model was used for risk ratios of binary outcomes while survival analysis was conducted with Cox regression and Fine Gray model for competing risk. Results: Of 32,234 patients, 28.92% were identified to have NAFLD. 36.04%, 38.32% and 25.63% were non-diabetic, prediabetic and diabetic respectively. Diabetic NAFLD significantly increased risk of cardiovascular disease (CVD), stroke, chronic kidney disease, all-cause and CVD mortality compared to non-diabetic NAFLD. However, prediabetic NAFLD only significantly increased the risk of CVD and did not result in a higher risk of mortality. Conclusions: Given the increased risk of adverse outcomes, this study highlights the importance of regular diabetes screening in NAFLD and adoption of prompt lifestyle modifications to reduce disease progression. Facing high cardiovascular burden, prediabetic and diabetic NAFLD individuals can benefit from early cardiovascular referrals to reduce risk of CVD events and mortality.

Is Surgical Resection Justified for Hepatocellular Carcinoma with Portal Vein Tumor Thrombus? (A Systematic Review and Meta-Analysis)

( Liang Lei ),( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Zhen-li Li ),( Jun Han ),( Han Zhang ),( Hao Xing ),( Han Wu ),( Ming-da Wang ),( Chao Li ),( Zheng Wang ),( Feng Shen ),( Meng-chao Wu ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: The prognosis of hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) is very poor. According to the BCLC treatment recommendations, sorafenib or other palliative treatment (PT) is recommended as the first-line therapy when it happens. In real world, however, a significant number of selected patients with HCC and PVTT suffered from surgical resection (SR). Methods: PubMed, Embase, Medline and Cochrane library were searched for studies comparing SR with PT (including TACE, sorafenib, etc.) for HCC with PVTT, which were published before September 2017. Results: 4,810 patients from 7 studies were enrolled in this meta-analysis, which divided into the SR group (n = 2,344) and the PT group (n = 2476). When compared with the PT group, the pooled hazard ratio (HR) for the 1, 3 and 5-year OS rates of the SR group were 0.56 (95% CI 0.52-0.60, P=0.03), 0.56 (95% CI 0.53-0.59, P<0.001) and 0.55 (95% CI 0.54-0.57, P<0.001). For subgroup analysis, when compared with the mere TACE group, the pooled HR for the 1, 3 and 5-year OS rates of the SR group were 0.54 (95% CI 0.43-0.67, P=0.81), 0.75 (95% CI 0.65-0.87, P=0.25) and 0.76 (95% CI 0.67-0.88, P=0.25). Conclusions: This meta-analysis demonstrated SR had better OS than TACE or other palliative therapy for HCC with PVTT. SR may be suitable as the first-line treatment for selected patients with resectable HCC and removable PVTT.

Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis

Han, Jun,Meng, Qing-Yang,Liu, Xiao,Xi, Qiu-Lei,Zhuang, Qiu-Lin,Wu, Guo-Hao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.