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MEHTA, Ahmed Muneeb,QAMRUZZAMAN, Md.,SERFRAZ, Ayesha,ALI, Asad Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3
This study's impetus is to explore fresh evidence to answer the question, i.e., whether remittances asymmetrically influence financial development in Bangladesh from 1975 to 2019. The study employs several tests, i.e., nonlinear unit root test, Autoregressive Distributed Lagged (ARDL), NARDL, and asymmetric causality test for establishing the pattern of association. Nonlinear unit root tests confirm that variables follow a nonlinear system of being stationary after the first difference. nonlinearity among variables is investigated by performing the BDS test and nonlinear OLS. Directional causality is investigated through both linear and nonlinear effects of remittance inflows by following the non-granger casualty test. The test statistics of Fpass and tBDM showed the Long-run cointegration in the empirical model and positive effect running from remittances inflow to financial development both in the long-run and short-run. Furthermore, the results of a standard Wald test divulge the presence of long-run and short-run asymmetry. Asymmetry causality test established unidirectional causality due to positive and negative shocks in remittances inflows to Bank-based financial development and feedback hypothesis hold for explaining causality between positive and negative shocks in remittance inflows and Stock-based financial development.
Mehta, Dhaval Tushar,Annamalai, Thangavelu,Ramanathan, Arvind Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Background: The epidermal growth factor receptor (EGFR) plays a vital role in the activation and inactivation of receptor tyrosine kinases. Mutations in exons 19 and 21 of EGFR are commonly found to be associated with non small cell lung carcinoma and triple negative breast cancer, enhancing sensitivity to EGFR targeting chemotherapeutic agents. Since amplification and prolonged activation of EGFR molecules have been identified in oral squamous cell carcinomas (OSCC), we investigated whether OSCCs carried mutations in exons 19 and 21 of EGFR to their incidence. Materials and Methods: Tumor chromosomal DNA isolated from forty surgically excised oral squamous cell carcinoma tissues was subjected to PCR amplification with intronic primers flanking exons 19 and 21 of the EGFR gene. The PCR amplicons were subsequently subjected to direct sequencing to elucidate the mutation status. Results: Data analysis of the EGFR exon 19 and 21 coding sequences did not show any mutations in the forty OSCC samples that were analyzed. Conclusions: To the best of our knowledge, this is the first study to have investigated the genetic status of exons 19 and 21 of EGFR in Indian OSCCs and identified that mutation in EGFR exon 19 and 21 may not contribute towards their genesis. The absence of mutations also indicates that oral cancerous lesions may not be as sensitive as other cancers to chemotherapeutic agents targeting EGFR.
Mehta, Sarika,Swarnkar, Neelam,Vyas, Madhuri,Vardia, Jitendra,Punjabi, Pinki B.,Ameta, Suresh C. Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.12
Under the framework of green chemistry, an efficient and extremely fast procedure for the synthesis of 5a-h through four-step procedure starting from 2-arylidenetetralin-1-one 1a-d under microwave irradiation is described. A considerable increase in the reaction rate has been observed with better yield. The structures of the synthesized compounds have been characterized on the basis of their elemental analysis and spectral data. Synthesized compounds 5a-h was evaluated for their antimicrobial activity. Some of the compounds exhibited appreciable activity.
Mehta, Pramod Kumar,Oh, Eun-Taex,Park, Heon Joo,Lee, Keun-Hyeung Elsevier 2017 Sensors and actuators. B Chemical Vol.245 No.-
<P><B>Abstract</B></P> <P>It is still a significant challenge to synthesize ratiometric fluorescent probes based on the new receptor with potent and tunable binding affinities for Zn<SUP>2+</SUP>. A fluorescent probe (<B>1</B>) based on the symmetric peptide receptor bearing two imidazole and two sulfonamide groups was synthesized for the ratiometric detection of Zn<SUP>2+</SUP> in aqueous solution. <B>1</B> selectively and sensitively detected Zn<SUP>2+</SUP> among biological relevant metal ions by a ratiometric response. Upon addition of Zn<SUP>2+</SUP>, monomer emissions of the pyrenes at 379 and 399nm increased significantly and the excimer emission at 508nm decreased with a blue shift. About 1 equiv of Zn<SUP>2+</SUP> ions completely induced the ratiometric response of <B>1</B>. Job’s plot analysis indicated that <B>1</B> formed a 1:1 complex with Zn<SUP>2+</SUP>. The dissociation constant for Zn<SUP>2+</SUP> was found to be 300 pM. The binding mode study revealed that two imidazole and two sulfonamide groups of the peptide receptor played an important role in the binding with Zn<SUP>2+</SUP>. The peptidyl probe successfully penetrated and detected intracellular Zn<SUP>2+</SUP> in live cells.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The fluorescent probe based on the peptide receptor with tunable binding affinities for Zn<SUP>2+</SUP>. </LI> <LI> Highly sensitive ratiometric response to Zn<SUP>2+</SUP> in aqueous solutions at physiological pH. </LI> <LI> A picomolar binding affinity (300 pM) for Zn<SUP>2+</SUP> in aqueous solutions and formation of a 1:1 complex. </LI> <LI> Highly selective response to Zn<SUP>2+</SUP> among various biological relevant metal ions. </LI> <LI> Cell penetration and detection of intracellular Zn<SUP>2+</SUP> in live cells. </LI> </UL> </P>
Investigation into the mechanism of action of Moringa oleifera for its anti-asthmatic activity
Mehta, Anita,Agrawal, Babita Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.1
In the present investigation, we studied the effect of alcoholic extract of Moringa oleifera (M. oleifera) seed kernels on various experimental models of bronchial asthma. Significant (P < 0. 05) increase in preconvulsion time was observed due to pretreatment with M. oleifera when the guinea pigs were exposed to either acetylcholine (Ach) or histamine aerosol. This bronchodilating effect of M. oleifera was comparable to ketotifen fumarate. Spasmolytic effect of M. oleifera was also observed by dose dependent inhibition of ideal contractions induced by Ach, 5HT, histamine and $BaCl_2$. Alcoholic extract of M. oleifera produced significant dose dependent protection by egg albumin and compound 48/80 induced mast cell degranulation. Pretreatment with alcoholic extract of M. oleifera also decreased carrageenan induced rat paw edema, which was comparable to that of standard diclofenac sodium. Minimum inhibitory concentration for alcoholic extract of M. oleifera was low as compared to cold-water extract and hot water extract when antimicrobial activity was tested against various respiratory pathogens like Escherichia coli (E. coli), Staphylococus aureus (S. aureus) and pseudomonas aeruginosa (P. aeruginosa). Our data suggest that antiasthmatic activity of M. oleifera seed kernels may be due to its bronchodilator, anti-inflammatory, mast cell stabilization and antimicrobial activity.
Analysis of payload compartment venting of satellite launch vehicle
Mehta, R.C. Techno-Press 2017 Advances in aircraft and spacecraft science Vol.4 No.4
The problem of flow through the vent is formulated as an unsteady, nonlinear, ordinary differential equation and solved using Runge-Kutta method to obtain pressure inside payload faring. An inverse problem for prediction of the discharge coefficient is presented employing measured internal pressure of the payload fairing during the ascent phase of a satellite launch vehicle. A controlled random search method is used to estimate the discharge coefficient from the measured transient pressure history during the ascent period of the launch vehicle. The algorithm predicts the discharge coefficient stepwise with function of Mach number. The estimated values of the discharge coefficients are in good agreement with differential pressure measured during the flight of typical satellite launch vehicle.
Mehta, Sanjay,Saadeghvaziri, M.A. Techno-Press 1998 Structural Engineering and Mechanics, An Int'l Jou Vol.6 No.7
An overview of an analytical model to predict mortar joint failure in unreinforced masonry (URM) structures is presented. The validity of the model is established by comparison with experimental results at element level as well as structure level. This model is then used to study the behavior of URM walls and two commonly used retrofitting schemes. Finally, effectiveness of the two retrofitting schemes in increasing strength and stiffness of existing URM walls is discussed.
Immunity and asthma: friend or foe?
Mehta, Anita,Gohil, Priyanshee Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.1
Immunity is responsible for the defense mechanism of the body but in case of autoimmune diseases, its role gets diverted. Like so many other diseases, asthma is also considered as one of the most common autoimmune diseases to be occurring in community. Asthma is defined as a chronic inflammatory airway disease that is characterized by airway hyper reactivity and mucus hypersecretion that result in intermittent airway obstruction. The incidence of allergic asthma has almost doubled in the past two decades. Although, precise causative mechanism of asthma is unknown, but several mechanisms have been proposed that is immunological, pharmacological and genetic mechanisms, and airway and neurogenic inflammation. The inflammatory process observed in the asthmatic patients is the final result of a complex network of interactions between various immunological cell lineages, its mediators and secreted substances. Thus, among the mechanisms proposed, the immunological one plays a key role. Through this article, we have tried to provide some insight into immunological mechanisms in pathogenesis of asthma.