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RISS 인기검색어
- 검색키워드
- 저자 : Md. Anisuzzaman Chowdhury (검색결과 3 건)
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Md. Anisuzzaman Chowdhury,고해주,이환,Md. Aminul Haque,박일선,이동성,우은란 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.3
Previous phytochemical investigations of Akebiae compound 1 and the inhibitory effects of components fromAkebiae Caulis on Ab42 fibrillogenesis. Caulis resulted in the isolation of triterpenes, triterpeneglycosides, phenylethanoid glycosides and megastigmaneglycoside. Amyloid beta (Ab), the main component of thesenile plaques detected in Alzheimer’s disease, induces celldeath. However, only a limited number of studies haveaddressed the biological and pharmacological effects ofAkebiae Caulis. In particular, the inhibitory activity ofAkebiae Caulis against Ab42 fibrillogenesis remainsunclear. Herein, a new triterpene glycoside, akequintoside F(1), along with nine known compounds pulsatilla saponin A(2), collinsonidin (3), akebonic acid (4), hederagenin (5),1-(30,40-dihydroxycinnamoyl) cyclopentane-2,3-diol (6),asperosaponin C (7), leontoside A (8), quinatic acid (9), andquinatoside A (10) were isolated from Akebiae Caulis usingrepeated column chromatography with silica gel, LiChroprepRP-18, and MCI gel. The chemical structures ofcompounds 1–10 were illustrated based on 1D and 2D NMRspectroscopy, including 1H-1H COSY, HSQC, HMBC andNOESY spectroscopic analyses. Compound 1 a novelcompound and known compounds 6 and 7 were isolated forthe first time from this plant. Among these compounds, 1, 3,4, 5 and 7 displayed significant inhibitory effects on Ab42induced fibrillogenesis. We present the first report of new
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김아련,구해주,Md. Anisuzzaman Chowdhury,장영수,우은란 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6
Ten compounds, 10,30-propanediol,20-amino-10-(1,3-benzodioxol-5-yl) (1), artanomaloide (2), canin (3),eupatilin (4), quercetin-3-O-b-D-glucoside-7-O-a-L-rhamnoside(5), 1,3-di-O-caffeoylquinic acid (6), isoquercitrin(7), pinoresinol-4-O-b-D-glucoside (8), scopolin (9), andisofraxidin-7-O-b-D-glucopyranoside (10) were isolatedfrom the aerial parts of A. selengensis. The structures ofcompounds (1–10) were identified based on 1D and 2DNMR, including 1H–1H COSY, HSQC, HMBC and NOESYspectroscopic analyses. Among them, compound 1was isolated from this plant for the first time as a naturallyoccurring compound. The inhibitory activity of these isolatedcompounds against interleukin-6 (IL-6) production inTNF-a stimulated MG-63 cells was also examined.
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A new indole glycoside from the seeds of Raphanus sativus
Hong-Guang Jin,Hae Ju Ko,Md. Anisuzzaman Chowdhury,Dong-Sung Lee,Eun-Rhan WOO 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
A new indole glycoside, b-D-glucopyranosyl2-(methylthio)-1H-indole-3-carboxylate, named raphanusideA (1), as well as eight known compounds, b-Dfructofuranosyl-(2 ? 1)-(6-O-sinapoyl)-a-D-glucopyranoside(2), (3-O-sinapoyl)-b-D-fructofuranosyl-(2 ? 1)-a-D-glucopyranoside (3), (3-O-sinapoyl)-b-D-fructofuranosyl-(2 ? 1)-(6-O-sinapoyl)-a-D-glucopyranoside (4), (3,4-Odisinapoyl)-b-D-fructofuranosyl-(2 ? 1)-(6-O-sinapoyl)-a-D-glucopyranoside (5), isorhamnetin 3,40-di-O-b-D-glucoside(6), isorhamnetin 3-O-b-D-glucoside-7-O-a-L-rhamnoside(7), isorhamnetin 3-O-b-D-glucoside (8) and 3’-O-methyl-(-)-epicatechin 7-O-b-D-glucoside (9) were isolated fromthe seeds of Raphanus sativus. Furthermore, compounds 1–3and 6–9, were isolated from this plant for the first time. Thestructures of compounds 1–9 were identified using 1D and 2DNMR, including 1H–1H COSY, HSQC, HMBC and NOESYspectroscopic analyses. The inhibitory activity of these isolatedcompounds against interleukin-6 (IL-6) production inTNF-a stimulated MG-63 cells was also examined.
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