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Mayasari Lim,Chua Shunjie,Nicki Panoskaltsis,Athanasios Mantalaris 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.1
In vitro differentiation of hematopoietic stem cells (HSCs) is a highly dynamic process whereby contributions of exogenous cytokines vary at each stage of differentiation. In this study, we present erythroid differentiation as three progressive yet independent stages and aim to elucidate transient contributions from stem cell factor (SCF), insulin-growth factor II (IGF-II), and erythropoietin (EPO). This will be accomplished using the Taguchi design and response surface methodology (RSM). We found that cultures with high process variability (noise factors), such as those in primary cell cultures, pose limitations on the effectiveness of RSM and result in inconsistencies in empirical models developed for elucidating transient effects. However, the Taguchi design--which showed greater robustness in accommodating for noise factors--successfully identified significant main and interactive contributions at each differentiation stage, thus highlighting the dynamic roles of each cytokine. The Taguchi analysis suggested high IGF-II dependency during early erythroid differentiation,with an antagonistic effect in the presence of EPO. At mid-stage differentiation, the roles of SCF and EPO dominate those of IGF-II, and the former act independently. Finally, toward erythroid maturation, only EPO plays a significant role. Although process outcomes from the Taguchi analysis were semi-quantitative, this approach provides a path for overcoming cell culture and sample-tosample variability and can therefore be utilized with many cell culture applications in order to understandcomplex and intricate process relationships.
The Effect of Liquidity Creation on Bank Capital: A Case Study in Indonesia
Ahmad FUAD,Disman DISMAN,Nugraha NUGRAHA,Mayasari MAYASARI,Ahmad FUAD 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.5
This paper aims to examine the moderating role of bank competition on the effect of liquidity creation on bank capital. We measure bank competition using the Lerner index approach, liquidity creation using the Catfat approach, and bank capital using the capital to total asset ratio approach. This test also considers control variables from bank-specific factors such as Return on Assets, Loan to Deposit Ratio, and Non-Performance Loans as well as macroeconomic factors such as Gross Domestic Product, inflation, and Bank Indonesia interest rates. The sampling technique used was purposive sampling. The data sample obtained was 96 banks from a population of 114 banks in Indonesia which consistently operated during the period 2008–2018. Hypothesis testing uses panel data regression analysis techniques through the first model of the Hayes method. The results show that the negative effect of liquidity creation on bank capital depends on competition. We found that bank competition at any level (low, medium, high) negatively moderates (weakens) the effect of liquidity creation on bank capital in all banks. This finding is consistent with the view that banks may strengthen their capital in response to bank competition which may decrease the level of bank liquidity creation.
김은기,Fitria MAYASARI,오인규 한국학중앙연구원 한국학중앙연구원 2013 Korea Journal Vol.53 No.4
Japanese hallyu fans who often travel to Korea after falling in love with Korean dramas or K-pop music are usually referred to as “tourist audiences.” More recently, K-pop tourist audiences come not only from Japan but also from Southeast Asia, China, Europe, and the Americas, expanding the nationality boundary of the concept. Although such tourist audiences are still predominantly female, the number of male K-pop tourist audience members is also growing slowly. In this study, we address the question of learning behavior among tourist audiences from different countries in the K-pop mecca of Seoul. Based on the notion of forward and retrospective learning, in-depth interviews with Japanese and Indonesian female K-pop fans who have encountered fans from other countries were conducted in order to delineate differing patterns of learning behavior. We find that forward learners from Indonesia actively engage in meeting Korean, Chinese, and Japanese fans, whereas retrospective learners from Japan are very reluctant to meet Chinese or Indonesian fans, although they were somewhat interested in meeting their North American or Western counterparts.