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Maurya, Ram Awatar,Hoang, Phan Huy,Kim, Dong-Pyo Royal Society of Chemistry 2012 Lab on a chip Vol.12 No.1
<P>Efficient and continuous monoacylation of symmetrical diamines performed in microreactors yielded superior selectivity to that predicted by statistical considerations. It is highly valuable that the kinetically controlled product in high yields was achieved without any special catalyst at ambient temperature.</P>
Coumarin-based combined computational study to design novel drugs against Candida albicans
Maurya Akhilesh Kumar,Mishra Nidhi 한국미생물학회 2022 The journal of microbiology Vol.60 No.12
Candida species cause the most prevalent fungal illness, candidiasis. Candida albicans is known to cause bloodstream infections. This species is a commensal bacterium, but it can cause hospital–acquired diseases, particularly in COVID-19 patients with impaired immune systems. Candida infections have increased in patients with acute respiratory distress syndrome. Coumarins are both naturally occurring and synthetically produced. In this study, the biological activity of 40 coumarin derivatives was used to create a three-dimensional quantitative structure activity relationship (3D-QSAR) model. The training and test minimum inhibitory concentration values of C. albicans active compounds were split, and a regression model based on statistical data was established. This model served as a foundation for the creation of coumarin derivative QSARs. This is a unique way to create new therapeutic compounds for various ailments. We constructed novel structural coumarin derivatives using the derived QSAR model, and the models were confirmed using molecular docking and molecular dynamics simulation.
Maurya, V.P.,Tuli, R.K.,Goyal, R.L. Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.2
Sixty semen ejaculates collected at weekly interval from four Murrah Buffalo bulls over a period of seven months (Nov.1999 to May 2000) were used in the present study. Three buffer medium (sodium citrate, TES and Tris) were used for soaking of sephadex. Three grades of sephadex (G-15,G-100, and G-200) were used for preparation of columns. Columns of three different height (one, two and three cm) were used for separation of semen. Twenty semen ejaculates were used in each project. In the first experiment each semen ejaculates was divided into four parts. One part was kept as control and other three parts were passed thought one cm column of sephadex G-15 prepared in three different buffers. There was significant (p<0.05) increase in percent progressive sperm motility and percent live spermatozoa and decrease in percent abnormal spermatozoa and percent spermatozoa with damaged acrosome as well as sperm numbers after filtration through all the three columns. Sperm quality obtained in the filtrate of column prepared in Tris buffer was better in comparison to other two buffers. So the Tris buffer was used in the second trial. Twenty semen ejaculates were used in this experiment. Each semen ejaculate was divided into four parts. One part was kept as control (non-filtered) and other three parts were passed through columns of different grade of sephadex (G-15, G-100 and G-200). Progressive sperm motility and live sperm percentage improved significantly while decline in percent abnormal spermatozoa and percent spermatozoa with damaged acrosome and sperm concentration was observed after filtration through all the columns as compared to control (non-filtered) semen. Since post filtration quality of semen was better in the sephadex G-100 column, therefore it was selected for the next experiment. In third experiment, Tris buffer and sephadex G-100 were used for preparing columns of different height (one, two and three cm) and twenty semen ejaculates were filtered. The quality characteristics of semen (percent progressive sperm motility, percent live spermatozoa and sperm concentration) after filtration through one cm column were significantly (p<0.05) higher than after filtration through columns of two and three cm height. However non -significant (p>0.05) difference due to height of columns was observed for percent abnormal and percent damaged acrosome but 1 cm column comparatively gave better result than of 2 and 3 cm column height.
Maurya, Ram Awatar,Min, Kyoung-Ik,Kim, Dong-Pyo The Royal Society of Chemistry 2014 GREEN CHEMISTRY Vol.16 No.1
<P>An integrated microfluidic system for multiple reactions and separations of hazardous ethyl diazoacetate is presented. The integrated techniques include: a droplet technique for liquid–liquid and/or gas–liquid separation and <I>in situ</I> generation of the toxic reagent, a dual channel membrane technique based on a cheap polymeric microseparator for liquid–liquid separation, and a capillary microreactor for carrying out cascade reactions in a sequential and continuous manner.</P> <P>Graphic Abstract</P><P>An integrated microfluidic system for multiple reactions and separations of hazardous ethyl diazoacetate is presented. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3gc41226a'> </P>
Challenges, Configuration, Control, and Scope of DC Microgrid Systems: A Review
Maurya Rinki,Prakash Surya,Singh Ashutosh Kumar 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.3
Managing natural resources and air pollution has been challenging for humans for quite a long time. A severe manifestation of natural resource mismanagement has been in the form of CO2 emissions from smoke bellowing thermal power plants (TPPs). Besides evoking global warming, the TPPs also foster limited coal reserve reduction with the increasing electricity demand. The ongoing scenario may lead to severe catastrophes until efficient plans for natural resource management are prepared. Many researchers have suggested DC microgrid as a credible alternative for power generation, significantly reducing carbon emissions. Efficient control strategies have brought microgrid technology to the level of other generation sources in terms of system reliability and efficiency. Renewable energy resources can be implemented as a safe, low voltage (< 50 V) local DC microgrid for DC load, reducing the converter requirement with low transmission losses and overcoming the scarcity of electricity. Seamless integration of solar-PV systems and batteries into the DC microgrid will increase the predominance of clean electricity in the modern power system. It will alleviate the air pollution problems generated by TPPs and sequels to enable natural resource management effectively. In light of the above facts, this paper presents a detailed survey on the challenges, configuration, control, and scope of DC microgrid systems. Various predominant configurations, recent advances in control strategies, operation challenges, and DC microgrid commissioning have been discussed. Moreover, a case study illustrating the benefits of DC systems is presented along with the energy-saving analysis compared with AC systems.
Effect of Thermal Stress on Sexual Behaviour of Superovulated Bharat Merino Ewes
Maurya, V.P.,Naqvi, S.M.K.,Gulyani, R.,Joshi, A.,Mittal, J.P. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.10
The present study was undertaken to study the effect of thermal stress on sexual behaviour of superovulated ewes. Fourteen adult Bharat Merino ewes with an average body weight of 29.4${\pm}$2.34 kg were randomly allocated into two groups of 7 each. All the animals were grazed on natural pasture in the morning and evening hours and housed in shed during night. Animals of Group-1 were housed in shed from 10:00 to 16:00 h while the animals of Group-2 were exposed to thermal stress in a hot chamber ($40^{\circ}C$ /6 h/day). All the animals were offered drinking water once a day at 16:30 h. Meteorological observations i.e. dry bulb, wet bulb, minimum and maximum temperature were recorded daily inside the shed as well as in hot chamber throughout the experimental period. For superovulation of animals, standard protocol developed at the Institute, using FSH (Ovagen 5.4 mg in eight injections) and PMSG (200 IU) was followed. Various sexual behaviour parameters (circling, tail fanning, head turning, standing and approaching to ram) and estrus incidence (onset of estrus and estrus duration) were observed in both the groups. The different estrus symptoms were graded subjectively on arbitrary scale of 0-5 where 0 representing no sexual behaviour (0%) and 5 representing maximum intensity in sexual behaviour (100%). Estrus was detected with the help of a marked aproned ram of proven vigor at six hourly intervals. The average percent values for sexual behaviour parameters recorded in Group-1 and Group-2 animals were 53.7${\pm}$3.76 vs. 41.1${\pm}$2.18 for circling, 71.8${\pm}$5.42 vs. 49.0${\pm}$4.41 for tail fanning, 64.7${\pm}$3.30 vs. 44.5${\pm}$4.34 for head turning, 90.1${\pm}$3.16 vs. 75.8${\pm}$4.02 for standing and 63.8${\pm}$4.8 vs. 41.9${\pm}$4.58 for approaching to ram. Animals exposed to thermal stress had significantly lower values of these sexual behaviour parameters. The animals kept in shed exhibited estrus earlier (25.4${\pm}$1.12 h) and duration was higher (37.7${\pm}$1.59 h) as compared to animals exposed to thermal stress i.e. 30.6${\pm}$1.16 h and 31.7${\pm}$3.57 h, respectively. The findings of the study indicate that thermal stress reduces the intensity of sexual behaviour in ewes and may result in failure of the animal to mate and conceive.