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Mathew, Aleyamma,George, Preethi Sara,Arjunan, Asha,Augustine, Paul,Kalavathy, MC,Padmakumari, G,Mathew, Beela Sarah Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
Background: Increasing breast cancer (BC) incidence rates have been reported from India; causal factors for this increased incidence are not understood and diagnosis is mostly in advanced stages. Trivandrum exhibits the highest BC incidence rates in India. This study aimed to estimate trends in incidence by age from 2005-2014, to predict rates through 2020 and to assess the stage at diagnosis of BC in Trivandrum. Materials and Methods: BC cases were obtained from the Population Based Cancer Registry, Trivandrum. Distribution of stage at diagnosis and incidence rates of BC [Age-specific (ASpR), crude (CR) and age-standardized (ASR)] are described and employed with a joinpoint regression model to estimate average annual percent changes (AAPC) and a Bayesian model to estimate predictive rates. Results: BC accounts for 31% (2681/8737) of all female cancers in Trivandrum. Thirty-five percent (944/2681) are <50 years of age and only 9% present with stage I disease. Average age increased from 53 to 56.4 years (p=0.0001), CR (per $10^5$ women) increased from 39 (ASR: 35.2) to 55.4 (ASR: 43.4), AAPC for CR was 5.0 (p=0.001) and ASR was 3.1 (p=0.001). Rates increased from 50 years. Predicted ASpR is 174 in 50-59 years, 231 in > 60 years and overall CR is 80 (ASR: 57) for 2019-20. Conclusions: BC, mostly diagnosed in advanced stages, is rising rapidly in South India with large increases likely in the future; particularly among post-menopausal women. This increase might be due to aging and/or changes in lifestyle factors. Reasons for the increased incidence and late stage diagnosis need to be studied.
Selected aryl thiosemicarbazones as a new class of multi-targeted monoamine oxidase inhibitors
Mathew, Bijo,Baek, Seung Cheol,Grace Thomas Parambi, Della,Pil Lee, Jae,Joy, Monu,Annie Rilda, P. R.,Randev, Rugma V.,Nithyamol, P.,Vijayan, Vijitha,Inasu, Sini T.,Mathew, Githa Elizabeth,Lohidakshan, The Royal Society of Chemistry 2018 MedChemComm Vol.9 No.11
<P>A series of 13 phenyl substituted thiosemicarbazones (SB1-SB13) were synthesized and evaluated for their inhibitory potential towards human recombinant monoamine oxidase A and B (MAO-A and MAO-B, respectively) and acetylcholinesterase. The solid state structure of SB4 was ascertained by the single X-ray diffraction technique. Compounds SB5 and SB11 were potent for MAO-A (IC50 1.82 ± 0.14) and MAO-B (IC50 0.27 ± 0.015 μM), respectively. Furthermore, SB11 showed a high selectivity index (SI > 37.0) for MAO-B. The effects of fluorine orientation revealed that SB11 (<I>m</I>-fluorine) showed 28.2 times higher inhibitory activity than SB12 (<I>o</I>-fluorine) against MAO-B. Furthermore, inhibitions by SB5 and SB11 against MAO-A and MAO-B, respectively, were recovered to near reference levels in reversibility experiments. Both SB5 and SB11 showed competitive inhibition modes, with <I>K</I>i values of 0.97 ± 0.042 and 0.12 ± 0.006 μM, respectively. These results indicate that SB5 and SB11 are selective, reversible and competitive inhibitors of MAO-A and MAO-B, respectively. Compounds SB5, SB7 and SB11 showed moderate inhibition against acetylcholinesterase with IC50 values of 35.35 ± 0.47, 15.61 ± 0.057 and 26.61 ± 0.338 μM, respectively. Blood-brain barrier (BBB) permeation was studied using the parallel artificial membrane permeation assay (PAMPA) method. Molecular docking studies were carried out using AutoDock 4.2.</P>
A Short Note on Inclusive and Exclusive Plurals in Korean
Michael Jonathan Mathew Barrie(Michael Jonathan Mathew Barrie ),Éric Mathieu(Éric Mathieu ) 한국생성문법학회 2023 생성문법연구 Vol.33 No.1
The aim of this short article is to give a comprehensive analysis of number in Korean, adding a novel observation about the interpretation of plurals in that language. Based on the new data, our proposal is that number is distributed along the nominal spine with different effects depending on the type of functional head (and semantic features) it is associated with. In particular, we propose that number in Korean is associated with two number projections, NumP1 and NumP2, (see Watanabe 2010 for Japanese, Vazquez Rojas Maldonado 2012 for Purépecha (isolate, tsz), Dali and Mathieu 2021 for Tunisian Arabic (Afro-Asiatic, aeb)). By shedding light on the distinction between inclusive and exclusive plurals in Korean and the relationship between definiteness and plurality, we contribute to the current debate related to the distribution of the Korean plural.
Dissecting Inchoatives and Causatives: English get constructions
Barrie Michael Jonathan Mathew,성문현 한국언어정보학회 2018 언어와 정보 Vol.22 No.3
Barrie, Michael Jonathan Mathew and Sung, Moonhyun. 2018. Dissecting Inchoatives and Causatives: English get Constructions. Language and Information, 22.3. 91-108. In this paper, we present data from English get-constructions and from Northern Iroquoian to challenge the recent consensus that in no languages are causatives built on inchoatives. Our data suggest the need for distinct functional projections for the causative and inchoative. We argue that while they are bundled in other situations, the functional heads for the causative and inchoative can be split as described in the present paper. This line of research follows recent trends in investigating the fine structure of the vP layer (Alexiadou et al. 2015, Harley 2013, Kim 2011, Marantz 2013, Pylkkänen 2008, Ramchand 2008, Legate 2014). We propose a syntactic mechanism for bundling and, in doing so, account for differences in the range of possible meanings with adverbs between canonical causatives and get-causatives. Briefly, get-causatives have unbundled causative and inchoative heads and have a wider ranger of adverbial meanings due to the projection of independent CausP and InchP. Canonical causatives have a bundled Caus-Inch head, projecting a single Caus/InchP, which leads to fewer sites for adverbs to adjoin and accordingly to a narrower range of adverbial meanings. (Sogang University)
SOME GENERALIZATIONS OF LOGISTIC DISTRIBUTION AND THEIR PROPERTIES
Mathew, Thomas,Jayakumar, K. The Korean Statistical Society 2007 Journal of the Korean Statistical Society Vol.36 No.1
The logistic distribution is generalized using the Marshall-Olkin scheme and its generalization. Some properties are studied. First order autoregressive time series model with Marshall-Olkin semi-logistic distribution as marginal is developed and studied.
Diffusion mediated selective adsorption of Zn<sup>2+</sup> from artificial seawater by MCM-41
Mathew, A.,Parambadath, S.,Kim, S.Y.,Ha, H.M.,Ha, C.S. Elsevier 2016 Microporous and mesoporous materials Vol.229 No.-
<P>MCM-41 can play a pivotal role as a host material for adsorption applications. In this work, MCM-41 was found to be 100% selective for Zn2+ from artificial seawater containing Ni2+, Li+, Co2+, Cd2+ and Zn2+ as hetero ions. The pristine and Zn2+ ions adsorbed MCM-41 (Zn@MCM-41) were well characterized by various spectroscopic techniques. The selective Zn2+ ion adsorption property of MCM-41 remained intact irrespective of the concentration of Zn2+ ions. The adsorption property of MCM-41 was unaffected by the synthesis strategy of MCM-41. SBA-15 exhibited 85 and 15% mole selectivity for Zn2+ and Cd2+ ions, respectively, under similar experimental conditions. This highlights the unique property of MCM-41 for the selective adsorption of Zn2+ ions from artificial seawater. TEM, FTIR and XPS analysis confirmed the presence of Zn2+ ions in Zn@MCM-41. The protection using methyl group on the outer/both surfaces of MCM-41 (Me-MCM-41/MeS-MCM-41) disclosed the necessity of interaction between silica surface and metal ion for selective adsorption of Zn2+ ions. The detailed investigation of adsorption mechanism postulates that the selective adsorption of Zn2+ ions by MCM-41 was achieved only in the presence of sodium chloride, which is the major component of artificial seawater. An adsorbed amount of 12 mg g(-1) was observed for Zn2+ ions even in presence of Cd2+ ions, while both of the ions possess similar chemical characteristics. (C) 2016 Elsevier Inc. All rights reserved.</P>
Rural Dvelopment Programmes in Sierra Leone: Analysis, Issues and Implications
( Mathew L. S. Gboku ) 한국농촌경제연구원 1987 Journal of Rural Development Vol.10 No.2
This paper is premised on the assumption that approaches to tackle rural development are still relatively new in Sierra Leone and sufficient time has not elapsed for proper evaluation of the more recent efforts. The paper provides learning experiences about the nature, complexity and scale of our own problems that could be of relevance to rural development practitioners in other developing countries with similar conditions like those of Sierra Leone. The main focus of the paper is an analysis of the various development programmes that have attempted to tackle the innumerable rural problems in the country. In the remaining parts of the paper, the author attempts to examine the successes, and outlint the issues and implications for better execution of future rural development programmes.
Amorphous iron phosphate: potential host for various charge carrier ions
Mathew, Vinod,Kim, Sungjin,Kang, Jungwon,Gim, Jihyeon,Song, Jinju,Baboo, Joseph Paul,Park, Wangeun,Ahn, Docheon,Han, Junhee,Gu, Lin,Wang, Yuesheng,Hu, Yong-Sheng,Sun, Yang-Kook,Kim, Jaekook Springer Science and Business Media LLC 2014 NPG Asia Materials Vol.6 No.-
C?H bond arylation of anilides inside copper-exchanged zeolites
Mathew, B.P.,Yang, H.J.,Jeon, H.,Lee, J.H.,Kim, J.C.,Shin, T.J.,Myung, K.,Kwak, S.K.,Kwak, J.H.,Hong, S.Y. Elsevier 2016 Journal of molecular catalysis Chemical Vol.417 No.-
<P>Syntheses of fine-chemicals using heterogeneous catalysts have tremendous industrial potentials, yet C-H functionalization studies have been largely focused on homogeneous catalysis. We report here the first meta-selective C-H bond arylation of anilides inside copper-exchanged zeolites. Mid- or large-pore zeolite frameworks are selected as supports to access large organic molecules, and atomically distributed copper catalysts exhibit high activities (84-90% conversions) toward direct arylation of anilides with diphenyliodonium salt on 0.5 mol% copper concentration. Computational studies indicate the well fitted copper-aryl complexes inside zeolite frameworks. Electron micrographs, elemental analyses, and reusability study show no observable leaching of catalytically active copper species during the reactions tested. These results demonstrate the practical synthetic potential of copper-exchanged zeolites as promising supported molecular catalysts to afford biaryl motifs-containing compounds with high catalytic activity, chemical stability, and recyclability. (C) 2016 Elsevier B.V. All rights reserved.</P>