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Kajitani, Koji,Ken-Ichi, Honda,Terada, Hiroyuki,Yasui, Tomoyo,Sumi, Toshiyuki,Koyama, Masayasu,Ishiko, Osamu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
The p53 gene is inactivated by the human papillomavirus (HPV) E6 protein in the majority of cervical cancers. Treatment of HeLa S3 cells with siRNA for HPV E6 permitted adenovirus-mediated transduction of a p53 gene linked to an upstream estrogen response element (ERE). Our previous study in non-siRNA treated HHUA cells, which are derived from an endometrial cancer and express estrogen receptor ${\beta}$, showed enhancing effects of an upstream ERE on adenovirus-mediated p53 gene transduction. In HeLa S3 cells treated with siRNA for HPV E6, adenovirus-mediated transduction was enhanced by an upstream ERE linked to a p53 gene carrying a proline variant at codon 72, but not for a p53 gene with arginine variant at codon 72. Expression levels of p53 mRNA and Coxsackie/adenovirus receptor (CAR) mRNA after adenovirus-mediated transfer of an ERE-linked p53 gene (proline variant at codon 72) were higher compared with those after non-ERE-linked p53 gene transfer in siRNA-treated HeLa S3 cells. Western blot analysis showed lower ${\beta}$-tubulin levels and comparatively higher p53/${\beta}$-tubulin or CAR/${\beta}$-tubulin ratios in siRNA-treated HeLa S3 cells after adenovirus-mediated ERE-linked p53 gene (proline variant at codon 72) transfer compared with those in non-siRNA-treated cells. Apoptosis, as measured by annexin V binding, was higher after adenovirus-mediated ERE-linked p53 gene (proline variant at codon 72) transfer compared with that after non-ERE-linked p53 gene transfer in siRNA-treated cells.
Takuya Misugi,Takashi Juri,Koichi Suehiro,Kohei Kitada,Yasushi Kurihara,Mie Tahara,Akihiro Hamuro,Akemi Nakano,Masayasu Koyama,Takasi Mori,Daisuke Tachibana 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.4
ObjectiveThis study aimed to investigate the accuracy and precision of continuous, non-invasive blood pressure obtained usingthe ClearSight system by comparing it with invasive arterial blood pressure, and to assess the hemodynamic changesusing invasive methods and the ClearSight system in patients undergoing cesarean section. MethodsArterial pressure was measured invasively with an intra-arterial catheter and non-invasively using the ClearSightsystem during cesarean section in patients with placenta previa or placenta accreta. Blood pressure measurementsobtained using these two means were then compared. ResultsTotal 1,277 blood pressure measurement pairs were collected from 21 patients. Under Bland-Altman analysis, theClearSight system demonstrated an acceptable accuracy with a bias and standard deviation of 8.8±13.4 mmHg forsystolic blood pressure, -6.3±7.1 mmHg for diastolic blood pressure, and -2.7±8.0 mmHg for median blood pressure. Cardiac index levels were significantly elevated during fetal delivery and 5 minutes after placental removal, andsystemic vascular resistance index levels were significantly decreased during fetal delivery and 40 minutes afterplacental removal. ConclusionIn patients undergoing cesarean section, the ClearSight system showed excellent accuracy and precision compared tothat of the currently used invasive monitoring system. 영어