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      • KCI등재

        Incremental Parsing in Conditionals and Relative Clauses in Korean

        Masaya Yoshida,윤수원,신정아 한국생성문법학회 2022 생성문법연구 Vol.32 No.4

        The strong head-finality of Korean raises many potential challenges to incremental parsing. In languages like Korean, there is normally no indication of clause structure before the parser encounters the verb or the relative head at the end of the clause. This uncertainty of clause structure can potentially give rise to processing difficulty of verbs in head-final languages. Developing our earlier studies in Japanese (Yoshida 2006), we present four series of experiments in Korean (offline and online) to show that there are, however, cases where the processing of clause-final verbs can indeed be predicted and facilitated.

      • PROPAGATION PROCESSES OF NEWLY DEVELOPED PLASMA JET IGNITER

        Masaya Ogawa,Hisatoshi Sasaki,Koji Yoshida,Hideo Shoji,Hidenori Tanaka 한국자동차공학회 2002 International journal of automotive technology Vol.3 No.1

        In plasma jet ignition, combustion enhancement effects occur toward the plasma jet issuing direction. Therefore, when the igniter is attached at the center of a cylindrically shaped combustion chamber, plasma jet should issue toward the round combustion chamber wall. The plasma jet igniter that had an annular circular orifice has been developed. The purpose of this study is to elucidate the relationship between the newly developed plasma jet igniter configuration and combustion enhancement effects. In this newly developed plasma jet igniter, flame front wrinkle appears on the flame front and flame propagates rapidly. Plasma jet influences on the flame propagation for long period when the plasma jet igniter has issuing angle 90 degrees and large cavity volume, because the plasma jet only lasts several ms. However, in the early stage of combustion, flame front area of issuing angle 45 degrees is larger than that of 90 degrees, because the initial flame kernel is formed by the plasma jet.<br/>

      • KCI등재후보

        Blood Fluidity Enhancement by Electrical Acupuncture Stimulation is Related to an Adrenergic Mechanism

        Shintaro Ishikawa,Hiroki Suga,Masaya Fukushima,Atsuhiro Yoshida,Yuri Yoshida,Masataka Sunagawa,Tadashi Hisamitsu 사단법인약침학회 2012 Journal of Acupuncture & Meridian Studies Vol.5 No.1

        We have reported that electrical acupuncture stimulation (ACU) increases blood fluidity by decreasing platelet aggregation. In this study, we investigated the mechanism causing the increase of blood fluidity. The effects of ACU on blood fluidity and platelet adhesion were examined using a Micro Channel Array Flow Analyzer (MC-FAN) and a laser scattering platelet aggregometer (PA-20). Male Wistar rats (7e8 weeks old) were used in the study. ACU (1 or 100 Hz, 3e5 V),which causes slight muscle twitching, was applied to the ZuSanli (ST-36) acupoint for 15 or 60 minutes once/day. Blood samples were collected from the inferior vena cava. ACU applied to ST-36 revealed significant increases in blood fluidity, while platelet adhesion activity decreased, regardless of the difference of stimulus time. The acupuncture had an immediate effect. Even if naloxone was administered during acupuncture stimulus, the blood flow time shortened in a similar way, as in the only acupuncture stimulus group. In addition, the effect of acupuncture on blood fluidity was inhibited by a b-antagonist. The results indicate that ACU affects blood fluidity depending on the acupoints, and that the effect of ACU might involve an endogenous adrenergic mechanism.

      • KCI등재

        High expression of folate receptor alpha is associated with poor prognosis in patients with cervical cancer

        Shu Yazaki,Yuki Kojima,Hiroshi Yoshida,Shigemasa Takamizawa,Rui Kitadai,Tadaaki Nishikawa,Tatsunori Shimoi,Kazuki Sudo,Ayumi Saito,Hitomi Sumiyoshi Okuma,Maki Tanioka,Emi Noguchi,Masaya Uno,Mitsuya Is 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.6

        Objective: Folate receptor α (FRα) is a membrane protein expressed in various solid tumors but has limited expression in normal cells. Therefore, FRα is an attractive target for cancer treatment. This study aimed to investigate the relationship between FRα expression and the clinicopathological characteristics and survivals of cervical cancer. Methods: This retrospective study included patients with cervical cancer who underwent primary surgery between 2000 and 2020 at our institution. Immunohistochemical staining of FRα was performed using an anti-folate-binding protein/FBP antibody. FRα-positive staining was defined as ≥5% of tumor staining and FRα-high as ≥50% tumor staining with ≥2+ intensity. The association between FRα expression and survival was assessed using multivariate Cox regression analysis, adjusting for established prognostic factors. Results: Overall, 123 patients were identified, and 140 tumor samples, including 17 paired primary and metastatic samples, were evaluated. As histological types, 67 patients had squamous cell carcinoma (SCC), and 56 patients had non-SCC. All primary tumors were FRα-positive. High FRα expression was observed in 25% of the cases and differed according to histology (SCC vs. non-SCC, 14.9% vs. 37.5%, p=0.004). FRα expression was significantly higher in metastatic tumors than in primary (170 [IQR, 140–205] vs. 125 [IQR, 110–150], p=0.0006). High FRα expression was significantly associated with worse overall survival (hazard ratio, 6.73; 95% confidence interval, 2.21–20.53; p=0.001). Conclusion: In cervical cancer, FRα expression was elevated in metastatic tumors and high expression was associated with a worse prognosis. Our study supports the development of FRα-targeted therapy for advanced cervical cancer.

      • SCISCIE

        Hot springs and cool natural products

        Kwon, Ho Jeong,Lee, Choong Hwan,Osada, Hiroyuki,Yoshida, Minoru,Imoto, Masaya Nature Publishing Group 2008 NATURE CHEMICAL BIOLOGY Vol.4 No.8

        Natural products have played a unique role in providing new tools and insights in chemical biology. The tremendous value of natural products was highlighted by scientists from Korea and Japan at the 4<SUP>th</SUP> Korea-Japan Chemical Biology symposium.

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