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Ménétrier’s Disease: Its Mimickers and Pathogenesis
Won Jae Huh,Robert J. Coffey,Mary Kay Washington 대한병리학회 2016 Journal of Pathology and Translational Medicine Vol.50 No.1
Ménétrier’s disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Ménétrier’s disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Ménétrier’s disease and the role of EGFR signaling in Ménétrier’s disease.