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HS-1793 protects C2C12 cells from oxidative stress via mitochondrial function regulation
MARQUEZ JUBERT,Park Nammi,Maria Victoria Faith Garcia,Kim Hyoung Kyu,Han Jin 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.4
Background HS1793, a novel analogue of resveratrol, was previously determined to be more potent at lower dosages by improving mitochondrial function and increased mitochondrial biogenesis-related proteins. In this study, we focused on targeting the mitochondria to address muscle wasting with HS-1793. Method Dosage screening was performed by evaluating for cytotoxicity and cell proliferation. Mitochondrial mass, mitochondrial membrane potential (Δψm), reactive oxygen species (ROS) level, and mitochondria biogenesis-regulated genes and proteins were analyzed to determine the efects on mitochondrial biogenesis. Results HS-1793 reduced ROS generation, but treatment did not interfere with cellular viability at low dosages. HS-1793 also regulated mitochondrial function by increasing cellular and mitochondrial ATP synthesis function, stabilizing Δψm and decreasing ROS. More importantly, these dysfunction in these parameters were ameliorated by HS-1793 in a simulated oxidative stress model with tBHP. We also observed increase in mitochondrial mass and upregulation in vital mitochondrial biogenesis-related gene PGC1-α as a response to HS-1793 treatment. Moreover, phosphorylation of AKT and mTOR proteins, which are considered as regulators of skeletal muscle function were also increased during the treatment. Finally, HS-1793 also demonstrated protective efects against cisplatin-induced skeletal muscle cell injury by increasing expression of mitochondrial biogenesis-relate markers. Conclusion Taken altogether, it shows the viability of HS-1793 as a compound that can restore mitochondrial function and render protection in skeletal muscle cells, especially during high oxidative stress levels.
Marquez, Francisco,Masa, Antonio,Cotto, Maria,Garcia, Abraham,Duconge, Jose,Campo, Teresa,Elizalde, Eduardo,Morant, Carmen Techno-Press 2014 Advances in energy research Vol.2 No.1
Photocatalytic hydrogen generation by water splitting ($H_2O_{(1)}{\rightarrow}H_2_{(g)}+1/2O_2_{(g)}$) has been studied on photocatalysts based on Zn, Cd, Fe and Cu, synthesized by coprecipitation. Iron and copper nanoparticles were incorporated as cocatalysts to enhance the photocatalytic activity of the ZnCd solid solution. The effect of the different synthesis parameters (temperature, elemental atomic ratios, amount of Cu and Fe incorporated in the catalyst and calcination temperature) on the photocatalytic production of hydrogen has been studied in order to determine the best experimental synthesis conditions. The catalysts have been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and BET. The experiments of photocatalytic water splitting were performed in aqueous solution of the photocatalysts previously dispersed in a soft ultrasound bath. The photocatalysts were irradiated under different lights ranging from 220 to 700 nm. The photocatalytic activity was found to be clearly dependent on the specific area of the photocatalyst.
Marquez, Victor E.,Jeong, Lak S.,Nicklaus, Marc C.,George, Cliff 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-
The efficient DAST fluorination of deoxy-4'-thiopyrimidine nucleosides is reported. The cytidine analogue 3b was marginally effective against HIV.
Marquez, Victor E.,Jeong, Lak S.,Nicklaus, Marc C.,George, Cliff 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5
The efficient DAST fluorination of deoxy-4'-thiopyrimidine nucleosides is reported. The cytidine analogue 3b was marginally effective against HIV.
Marquez-Rios, Enrique,Cota-Arriola, Octavio,Villalba-Villalba, Ana Gloria,Ezquerra-Brauer, Josafat Marina,Ocano-Higuera, Victor Manuel,Lopez-Corona, Betzabe Ebenhezer,Torres-Arreola, Wilfrido 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4
Chymotrypsin was purified from jumbo squid hepatopancreas (HP) with 2.4-fold and yield 1.9%, and characterized with a molecular weight of 31 kDa, as estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Chymotrypsin effect over collagen extracted from the mantle, fins and arms of the jumbo squid was evaluated. The enzyme exhibited the maximum activity at pH 7 and $65^{\circ}C$ using Suc-Ala-Ala-Pro-Phe-p-nitroanilide (SAAPNA) as a substrate and it was identified using the specific inhibitors N-tosyl-L-phenylalaninechloromethyl ketone (TPCK) and phenyl methyl sulfonyl fluoride (PMSF), showing residual activities of 6% and 0%, respectively. Furthermore, high activity was observed in the pH range of 4.0 to 8.0. Purified enzyme showed a moderate in vitro activity using muscle collagen as a substrate. Although further research is needed, the results suggest that the enzyme has a potential application where acidic or slightly alkaline conditions are needed.
Packet Output and Input Configuration in a Multicasting Session Using Network Coding
( Jose Marquez ),( Ismael Gutierrez ),( Sebastian Valle ),( Melanis Falco ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.2
This work proposes a model to solve the problem of Network Coding over a one-session multicast network. The model is based on a system of restrictions that defines the packet flows received in the sink nodes as functions of the outgoing flows from the source node. A multicast network graph is used to derive a directed labeled line graph (DLLG). The successive powers of the DLLG adjacency matrix to the convergence in the null matrix permits the construction of the jump matrix Source-Sinks. In its reduced form, this shows the dependency of the incoming flows in the sink nodes as a function of the outgoing flows in the source node. The emerging packets for each outgoing link from the source node are marked with a tag that is a linear combination of variables that corresponds to powers of two. Restrictions are built based on the dependence of the outgoing and incoming flows and the packet tags as variables. The linear independence of the incoming flows to the sink nodes is mandatory. The method is novel because the solution is independent of the Galois field size where the packet contents are defined.
Economic Integration Effects on Trade Margins: Sectoral Evidence from Latin America
( Laura Marquez-ramos ),( Luis Marcelo Florensa ),( Maria Luisa Recalde ) 세종대학교 경제통합연구소 2015 Journal of Economic Integration Vol.30 No.2
The present paper aims to determine the effects of different levels of economic integration on the intensive and the extensive margins of trade. Specifically, the analysis focuses on the case of Latin America. It is of great importance for development policies in the region since the extensive margin can be defined as those exports that provide new market entrants, while the intensive margin is due to continued growth in sales of old exporters to the same destinations. Therefore, obtained results have important policy implications related to diversification strategies. The long-term period considered will allow us to determine whether different effects on trade margins might arise in the following two sub-periods: 1962~1989 and from 1990 onwards, i.e. before and after the spread of regional integration agreements and the deepening of the liberalization process in the region. Finally, we focus on those specific sectors in which Latin American countries present a higher relative participation of trade. The obtained results show that the effect of economic integration is both time and period sensitive. The main positive effects are found to be reflected in the intensive margin for all different types of agreements. Moreover, we find that deeper economic integration agreements have the greatest effect on trade margins.
Understanding the Determinants of Economic Integration in Latin America
( Laura Marquez-ramos ),( Luis Marcelo Florensa ),( Maria Luisa Recalde ) 세종대학교 경제통합연구소(구 세종대학교 국제경제연구소) 2017 Journal of Economic Integration Vol.32 No.3
When signing or enhancing trade agreements with Latin America, political and institutional factors play a more important role at present compared with their role in the past. In addition, a better institutional framework increases covered and legally enforceable provisions in Latin America trade agreements. This paper analyzes the determinants of economic integration in Latin America and the institutional quality of signed trade agreements with this region. By focusing on both a discrete choice and a linear framework, the study results prove that economic, geographic, institutional, and political factors influence economic integration. This is because these aspects are key elements in the formation and enhancement of trade agreements both within and outside Latin America. This study considers the role of additional exogenous political facts, such as the September 11 attacks in New York City, and the Revolucion Bolivariana, a leftist movement in Venezuela, which affected economic integration in Latin America.
Felipe Marquez-Grados,Enzo Vettorato,Federico Corletto 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.1
This study reports the clinical use of two sevoflurane-based anesthetic techniques in dogs undergoing craniectomy. Twenty-one animals undergoing elective rostrotentorial or transfrontal craniectomy for brain tumor excision, anesthetized with sevoflurane, were enrolled in this retrospective, observational study. Anesthetic records were allocated to two groups: Sevo-Op (sevoflurane and short acting opioid infusion): 8 dogs and Sevo-Dex (sevoflurane and dexmedetomidine infusion): 13 dogs. Average mean arterial pressure (MAP), heart rate, end-tidal carbon dioxide, end-tidal sevoflurane and intraoperative infusion rates during surgery were calculated. Presence of intra-operative and post-operative bradycardia, tachycardia, hypotension, hypertension, hypothermia, hyperthermia was recorded. Time to endotracheal extubation, intraoperative occurrence of atrioventricular block, postoperative presence of agitation, seizures, use of labetalol and dexmedetomidine infusion were also recorded. Data from the two groups were compared with Fisher's exact test and unpaired t tests with Welch's correction. Odds ratio (OR) and 95% confidence interval (CI) were calculated for categorical variables. Intra-operatively, MAP was lower in Sevo-Op [85 (± 6.54) vs. 97.69 (± 7.8) mmHg, p = 0.0009]. Time to extubation was longer in Sevo-Dex [37.69 (10–70) vs. 19.63 (10–25), p = 0.0033]. No differences were found for the other intra-operative and post-operative variables investigated. Post-operative hypertension and agitation were the most common complications (11 and 12 out of 21 animals, respectively). These results suggest that the infusion of dexmedetomidine provides similar intra-operative conditions and post-operative course to a short acting opioid infusion during sevoflurane anesthesia in dogs undergoing elective rostrotentorial or transfrontal intracranial surgery.