지리교수에 있어서 탐구적 접근의 이용

March, Colin J. 청주대학교 사회(지리)교육학과 2003 淸州地理 Vol.18 No.-

Rapidly Growing and Aggressive Cutaneous Squamous Cell Carcinomas in a Patient Treated with Ruxolitinib

( Alvaro March-rodriguez ),( Beatriz Bellosillo ),( Alberto Alvarez-larran ),( Carles Besses ),( Ramon M Pujol ),( Agusti Toll ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Ruxolitinib is a Janus kinase (JAK)1 and JAK2 inhibitor approved for the treatment of myelofibrosis and for polycythemia patients who are resistant or intolerant to hydroxyurea. We report a 72 year-old man patient with polycythemia vera who developed multiple cutaneous squamous cell carcinomas (cSCCs) with keratoacanthoma-like histological features while on treatment with ruxolitinib. Similar lesions have been reported in an isolated patient who also received ruxolitinib. Our case confirms that ruxolitinib may induce eruptive cSCCs with characteristic clinical and histological features that differentiate them from conventional non-drug induced lesions. Moreover, we performed a mutational panel analysis of the tumors. The lack of specific mutations in these tumors suggests an impairment of immunosurveillance in the origin of the cutaneous lesions. Frequent and thorough dermatological examinations in patients receiving ruxolitinib with a history of photodamage, skin cancer and/or previous hydroxyurea intake is thus recommended. (Ann Dermatol 31(2) 204∼208, 2019)

Food Regulation – the Economic and Social Science Revolution

Jason March 식품안전정보원 2020 식품법과 정책 Vol.- No.1

식품 규제 – 경제사회과학 혁명

Jason March 식품안전정보원 2020 식품법과 정책 Vol.- No.1

A Cultural-Historical Reading of the Emotional Development of Young Children

Marilyn Fleer,Marie Hammer,Sue March 환태평양유아교육연구학회 2014 Asia-Pacific journal of research in early childhoo Vol.8 No.2

The telling of fairytales has been a longstanding practice within the field of early childhood education in many communities across the Asia Pacific region. But what do we know about how educators use fairytales for the development of emotions for preschool aged children? In drawing upon culturalhistorical theory (Vygotsky, 1971, 1987, 1999), this paper presents the findings of a study into how fairytales were introduced to preschool aged children (n=30; from 3.3 to 5.3 years with mean age 4.2 years) and theorises the value of fairytales for the development of children’s emotions in the context of the pedagogical conditions that are created through the use of fairytales. A pedagogical framework is introduced which captures the unique characteristics of fairy tales in the context of the pedagogical features that were used by the educators in the study presented. The key concept of affective imagination or emotional imagination is used to discuss the fairytale of “Jack and the Beanstalk” from the data set of 74 hours of digital video observations gathered over 16 preschool sessions.

COCCIDIOSIS CONTROL IN THE EUROPEAN UNION. CURRENT SITUATION AND FUTURE CHALLENGES

Marc Pagès,M. Dardi,M. de Gussem,J. Rubio,R. March,M. Shirley,D. Blake,E. del Cacho 한국가금학회 2012 한국가금학회 심포지움 Vol.2012 No.5

Avian coccidiosis is one of the most important diseases affecting the intensive poultry industry worldwide. Despite its outstanding importance and well-known relation with other factors that may influence the health status of the birds and its commercial performance, few studies are available on the distribution of Eimeria species in the field. In Europe the studies available until the present date are, Czech Republic(Kučera, 1990), France(Williams, 1996), UK(Chapman, 1982, Shirley 1995, Shirley 1997, Williams 2006, Eckert 1995), Norway(Haug, 2008)and Sweden(Thebo, 1998). Most of the published studies have been focused on identifying the seven species of Eimeria which affect Gallus gallus in a European country. However, the only survey that has been done exclusively with samples from broiler farms of Norway is Haug, 2008. In the present study, litter samples obtained in broiler farms from Spain, Belgium, Italy and France were evaluated for the presence of Eimeria species. The evaluation was done using a polymerase chain reaction(PCR) developed at IAH to specifically detect E.acervulina, E.maxima, E.mitis, E.praecox and E.tenella. Together with this molecular tool, oocyst counts and a morphometric evaluation test were also used to analyse the samples. Results obtained provide interesting data on the prevalence of species which affect the broiler birds in Europe as well as the percentage of farms with presence of each species. Together with prevalence data, rotation programs(anticoccidials-vaccines) appear to be of paramount importance to upgrade the flock performances. Data obtained in farms from the Netherlands confirms the advantage of using rotation programs with vaccines composed of Eimeria strains sensitive to anticoccidials.

Comprehensive Experimental and Computational Spectroscopic Study of Hexacyanoferrate Complexes in Water: From Infrared to X-ray Wavelengths

Ross, Matthew,Andersen, Amity,Fox, Zachary W.,Zhang, Yu,Hong, Kiryong,Lee, Jae-Hyuk,Cordones, Amy,March, Anne Marie,Doumy, Gilles,Southworth, Stephen H.,Marcus, Matthew A.,Schoenlein, Robert W.,Mukame American Chemical Society 2018 The journal of physical chemistry. B, Condensed ma Vol.122 No.19

<P>We present a joint experimental and computational study of the hexacyanoferrate aqueous complexes at equilibrium in the 250 meV to 7.15 keV regime. The experiments and the computations include the vibrational spectroscopy of the cyanide ligands, the valence electronic absorption spectra, and Fe 1s core hole spectra using element-specific-resonant X-ray absorption and emission techniques. Density functional theory-based quantum mechanics/molecular mechanics molecular dynamics simulations are performed to generate explicit solute-solvent configurations, which serve as inputs for the spectroscopy calculations of the experiments spanning the IR to X-ray wavelengths. The spectroscopy simulations are performed at the same level of theory across this large energy window, which allows for a systematic comparison of the effects of explicit solute-solvent interactions in the vibrational, valence electronic, and core-level spectra of hexacyanoferrate complexes in water. Although the spectroscopy of hexacyanoferrate complexes in solution has been the subject of several studies, most of the previous works have focused on a narrow energy window and have not accounted for explicit solute-solvent interactions in their spectroscopy simulations. In this work, we focus our analysis on identifying how the local solvation environment around the hexacyanoferrate complexes influences the intensity and line shape of specific spectroscopic features in the UV/vis, X-ray absorption, and valence-to-core X-ray emission spectra. The identification of these features and their relationship to solute-solvent interactions is important because hexacyanoferrate complexes serve as model systems for understanding the photochemistry and photophysics of a large class of Fe(II) and Fe(III) complexes in solution.</P> [FIG OMISSION]</BR>

Using Ultrafast X-ray Spectroscopy To Address Questions in Ligand-Field Theory: The Excited State Spin and Structure of [Fe(dcpp)₂]²⁺

Britz, Alexander,Gawelda, Wojciech,Assefa, Tadesse A.,Jamula, Lindsey L.,Yarranton, Jonathan T.,Galler, Andreas,Khakhulin, Dmitry,Diez, Michael,Harder, Manuel,Doumy, Gilles,March, Anne Marie,Bajno American Chemical Society 2019 Inorganic chemistry Vol.58 No.14

<P>We have employed a range of ultrafast X-ray spectroscopies in an effort to characterize the lowest energy excited state of [Fe(dcpp)<SUB>2</SUB>]<SUP>2+</SUP> (where dcpp is 2,6-(dicarboxypyridyl)pyridine). This compound exhibits an unusually short excited-state lifetime for a low-spin Fe(II) polypyridyl complex of 270 ps in a room-temperature fluid solution, raising questions as to whether the ligand-field strength of dcpp had pushed this system beyond the <SUP>5</SUP>T<SUB>2</SUB>/<SUP>3</SUP>T<SUB>1</SUB> crossing point and stabilizing the latter as the lowest energy excited state. Kα and Kβ X-ray emission spectroscopies have been used to unambiguously determine the quintet spin multiplicity of the long-lived excited state, thereby establishing the <SUP>5</SUP>T<SUB>2</SUB> state as the lowest energy excited state of this compound. Geometric changes associated with the photoinduced ligand-field state conversion have also been monitored with extended X-ray absorption fine structure. The data show the typical average Fe-ligand bond length elongation of ∼0.18 Å for a <SUP>5</SUP>T<SUB>2</SUB> state and suggest a high anisotropy of the primary coordination sphere around the metal center in the excited <SUP>5</SUP>T<SUB>2</SUB> state, in stark contrast to the nearly perfect octahedral symmetry that characterizes the low-spin <SUP>1</SUP>A<SUB>1</SUB> ground state structure. This study illustrates how the application of time-resolved X-ray techniques can provide insights into the electronic structures of molecules-in particular, transition metal complexes-that are difficult if not impossible to obtain by other means.</P><P>Time-resolved X-ray emission and absorption spectroscopies have been used to probe the excited-state electronic and geometric structure of an Fe(II) polypyridyl complex. Analysis of the data revealed that the lowest energy excited state is high-spin (<I>S</I> = 2) in character. This determination had not been possible using other experimental techniques (e.g., time-resolved optical spectroscopy), demonstrating the potential for ultrafast X-ray methods to address scientific questions that are difficult to resolve by other means.</P> [FIG OMISSION]</BR>