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RISS 인기검색어
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- 저자 : Marc Ferrer (검색결과 3 건)
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Marc Ferrer,Óscar Soto-Angona,María Soler-Artigas,Pol Ibáñez,Christian Fadeuilhe,Raúl Felipe Palma-Álvarez,Raquefet Lidai,Sebastian Vargas-Cáceres,María Ángeles Torrecilla,Anna López,Josep Antoni Ramo 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3
Objective: Agitation in patients diagnosed with personality disorders (PD) is one of the most frequent crises in emergency departments (ED). Although many medications have been tested, their effectiveness has been small or non-significant, and no specific drugs are supported by the available evidence. This study aimed to evaluate the efficacy of Inhaled loxapine (IL) as a therapeutic option for agitated patients with PD. Methods: A naturalistic, unicentric, prospective study was carried out. Thirty subjects diagnosed with PD and attending the ED with episodes of agitation were recruited most of whom were women diagnosed with Borderline Personality Disorder. Subjects were treated with a single dose of IL (9.1 mg). Efficacy was assessed with the Clinical Global Impression scale, the Excited Component of the Positive and Negative Syndrome Scale (PANSS-EC) and the Agitation-Calmness Evaluation Scale (ACES). Patients were followed 60 minutes after administration to measure IL effect and its duration. Results: IL exhibited an overall efficacy in managing mild to severe agitation, with a quick onset of effect and persistence. ‘Effect of time’, where IL efficacy is maintained over time, is more marked in higher-severity agitation. No additional treatments were needed to improve agitation during the follow-up time. Conclusion: Results suggest that IL could be a safe and effective option to manage agitation in PD.
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The role of evidence-based algorithms for rotational thromboelastometry-guided bleeding management
Klaus Görlinger,Antonio Pérez-Ferrer,Daniel Dirkmann,Fuat Saner,Marc Maegele,Ángel Augusto Pérez Calatayud,김태엽 대한마취통증의학회 2019 Korean Journal of Anesthesiology Vol.72 No.4
Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided bleeding management has become an essential part of patient blood management (PBM) which is an important concept in improving patient safety. Here, ROTEM testing and hemostatic interventions should be linked by evidence-based, setting-specific algorithms adapted to the specific patient population of the hospitals and the local availability of hemostatic interventions. Accordingly, ROTEM-guided algorithms implement the concept of personalized or precision medicine in perioperative bleeding management (‘theranostic’ approach). ROTEM-guided PBM has been shown to be effective in reducing bleeding, transfusion requirements, complication rates, and health care costs. Accordingly, several randomized-controlled trials, meta-analyses, and health technology assessments provided evidence that using ROTEM-guided algorithms in bleeding patients resulted in improved patient’s safety and outcomes including perioperative morbidity and mortality. However, the implementation of ROTEM in the PBM concept requires adequate technical and interpretation training, education and logistics, as well as interdisciplinary communication and collaboration.
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A review on anaerobic membrane bioreactors (AnMBRs) focused on modelling and control aspects
Robles, Á,ngel,Ruano, Maria Victoria,Charfi, Amine,Lesage, Geoffroy,Heran, Marc,Harmand, Jé,rô,me,Seco, Aurora,Steyer, Jean-Philippe,Batstone, Damien J.,Kim, Jeonghwan,Ferrer, Jos&eac Elsevier 2018 Bioresource technology Vol.270 No.-
<P><B>Abstract</B></P> <P>The use of anaerobic membrane bioreactor technology (AnMBR) is rapidly expanding. However, depending on the application, AnMBR design and operation is not fully mature, and needs further research to optimize process efficiency and enhance applicability. This paper reviews state-of-the-art of AnMBR focusing on modelling and control aspects. Quantitative environmental and economic evaluation has demonstrated substantial advantages in application of AnMBR to domestic wastewater treatment, but detailed modelling is less mature. While anaerobic process modelling is generally mature, more work is needed on integrated models which include coupling between membrane performance (including fouling) and the biological process. This should include microbial factors, which are important to generation of specific foulants such as soluble and particulate inert organics. Mature and well-established control tools, including better feedback control strategies are also required for both the process, and for fouling control.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AnMBR needs further research to optimize process efficiency. </LI> <LI> Modelling can provide insight into the factors playing a key role in AnMBR. </LI> <LI> Process models still face a long path to adaptation in practice. </LI> <LI> Better understanding of fouling mechanisms in AnMBRs is required. </LI> <LI> Control strategies can be further optimized from mechanistic knowledge of fouling. </LI> </UL> </P>
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