Postoperative circulating tumor DNA detection and CBLB mutations are prognostic biomarkers for gastric cancer

Zhou Hekai,Liu Houcong,Li Jun,Wang Jidong,Fu Xiaohong,Li Yingqiang,Mao Shaolong,Du Jihui 한국유전학회 2023 Genes & Genomics Vol.45 No.8

Background Several studies have demonstrated that circulating tumor DNA (ctDNA) can be used to predict the postoperative recurrence of several cancers. However, there are few studies on the use of ctDNA as a prognosis tool for gastric cancer (GC) patients. Objective This study aims to determine whether ctDNA could be used as a prognostic biomarker in GC patients through multigene-panel sequencing. Methods Using next-generation sequencing (NGS) Multigene Panels, the mutational signatures associated with the prognosis of GC patients were identified. We calculated the survival probability with Kaplan–Meier and used the Log-rank test to compare survival curves between ctDNA-positive and ctDNA-negative groups. Potential application of radiology combined with tumor plasma biomarker analysis of ctDNA in GC patients was carried out. Results Disease progression is more likely in ctDNA-positive patients as characterized clinically by a generally higher T stage and a poorer therapeutic response (P < 0.05). ctDNA-positive patients also had worse overall-survival (OS: P = 0.203) and progression-free survival (PFS: P = 0.037). The combined analysis of ctDNA, radiological, and serum biomarkers in four patients indicated that ctDNA monitoring can be a good complement to radiological and plasma tumor markers for GC patients. Kaplan–Meier analysis using a cohort of GC patients in the TCGA database showed that patients with CBLB mutations had shorter OS and PFS than wild-type patients (OS: P = 0.0036; PFS: P = 0.0027). Conclusions This study confirmed the utility and feasibility of ctDNA in the prognosis monitoring of gastric cancer.

Long-Term Outcomes after D2 Gastrectomy for Early Gastric Cancer: Survival Analysis of a Single-Center Experience in China

Wang, Zheng,Ma, Li,Zhang, Xing-Mao,Zhou, Zhi-Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Background: Early gastric cancer (EGC) is well accepted as having a favorable prognosis, but some patients experience an ominous outcome after curative resection. This study was aimed at evaluating predictive factors associated with prognosis of D2 gastrectomies in patients with early gastric cancer. Materials and Methods: A total of 518 patients with early gastric cancer who underwent D2 gastrectomies were reviewed in this study. The clinicopathological features and surgical outcomes were analyzed. The survival rate was estimated using the Kaplan-Meier method and compared by log rank test. Prognostic factors were analyzed using a multivariate Cox proportional hazards model. Results: The 5-year survival rate was 90.3%. Tumor infiltration, lymph node metastasis and lymphovascular invasion were significant prognostic factors for survival. Gender, age, tumor size, tumor location, macroscopic type and histological type were not significant prognostic factors. Multivariate analysis indicated that lymph node metastasis was an independent poor prognosis factor. Conclusions: Early gastric cancers with lymph node metastasis have a relatively poor prognosis after standard surgery. Even after curative resection, patients with EGC with positive lymph nodes should be closely followed and be considered as candidates for comprehensive therapies.

Risk of Lymph Node Metastases from Early Gastric Cancer in Relation to Depth of Invasion: Experience in a Single Institution

Wang, Zheng,Ma, Li,Zhang, Xing-Mao,Zhou, Zhi-Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

Background: An accurate assessment of potential lymph node metastasis is important for the appropriate treatment of early gastric cancers. Therefore, this study analyzed predictive factors associated with lymph node metastasis and identified differences between mucosal and submucosal gastric cancers. Materials and Methods: A total of 518 early gastric cancer patients who underwent radical gastrectomy were reviewed in this study. Clinicopathological features were analyzed to identify predictive factors for lymph node metastasis. Results: The rate of lymph node metastasis in early gastric cancer was 15.3% overall, 3.3% for mucosal cancer, and 23.5% for submucosal cancer. Using univariate analysis, risk factors for lymph node metastasis were identified as tumor location, tumor size, depth of tumor invasion, histological type and lymphovascular invasion. Multivariate analysis revealed that tumor size >2 cm, submucosal invasion, undifferentiated tumors and lymphovascular invasion were independent risk factors for lymph node metastasis. When the carcinomas were confined to the mucosal layer, tumor size showed a significant correlation with lymph node metastasis. On the other hand, histological type and lymphovascular invasion were associated with lymph node metastasis in submucosal carcinomas. Conclusions: Tumor size >2 cm, submucosal tumor, undifferentiated tumor and lymphovascular invasion are predictive factors for lymph node metastasis in early gastric cancer. Risk factors are quite different depending on depth of tumor invasion. Endoscopic treatment might be possible in highly selective cases.

The establishment of IB-SEM numerical method and verification of fluid-solid interaction

Wang, Jing,Li, Shu-cai,Mao, Xuerui,Li, Li-ping,Shi, Shao-shuai,Zhou, Zong-qing Techno-Press 2018 Geomechanics & engineering Vol.15 No.6

The interaction between particles and fluid was investigated by IB-SEM numerical method which is a combination of combing the spectral/hp element method and the rigid immersed boundary method. The accuracy of this numerical method was verified based on the computed results with the traditional body-fitted mesh in numerical simulation of the flow through the cylinder. Then the governing equations of particles motion and contact in fluid are constructed. The movement of the particles and the interaction between the fluid and the particles are investigated. This method avoided the problem of low computational efficiency and error caused by the re-division of the grid when the solids moved. Finally, the movement simulation of multi particles in the fluid was carried out, which can provide a completely new numerical simulation method.

A New Iterative LT Decoding Algorithm for Binary and Nonbinary Galois Fields

Mao, Yuexin,Huang, Jie,Wang, Bing,Huang, Jianzhong,Zhou, Wei,Zhou, Shengli The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.4

Digital fountain codes are record-breaking codes for erasure channels. They have many potential applications in both wired and wireless communications. Most existing digital fountain codes operate over binary fields using an iterative belief-propagation (BP) decoding algorithm. In this paper, we propose a new iterative decoding algorithm for both binary and nonbinary fields. The basic form of our proposed algorithm considers both degree-1 and degree-2 check nodes (instead of only degree-1 check nodes as in the original BP decoding scheme), and has linear complexity. Extensive simulation demonstrates that it outperforms the original BP decoding scheme, especially for a small number of source packets. The enhanced form of the proposed algorithm combines the basic form of the algorithm and a guess-based algorithm to further improve the decoding performance. Simulation results demonstrate that it can provide better decoding performance than the guess-based algorithm with fewer guesses, and can achieve decoding performance close to that of the maximum likelihood decoder at a much lower decoding complexity. Last, we show that our nonbinary scheme has the potential to outperform the binary scheme when choosing suitable degree distributions, and furthermore it is insensitive to the size of the Galois field.

Research on Key Technologies of End to side Computing Network based on Field Level AI Reasoning for Terminal Equipment

Mao Ni,Ting Zhou,Hengjiang Wang,Fang Cui 대한전자공학회 2023 IEIE Transactions on Smart Processing & Computing Vol.12 No.6

This study analyzes the field-level AI reasoning technology of its terminal equipment and applies it to optimizing computing resources under the cooperation of multiple UAVs. The experimental results indicates that the performance of the ICEM method is superior to the other three methods, and the maximum value is 15 × 10<SUP>8</SUP> bits/Joule. An increase of 10 thresholds can reduce the number of iterations 50-fold when the amount of CDF iterations is 0.9. This can reach more than 20 times if the number of UAVs and mobile terminal devices doubles. The UAV will run at the maximum speed in most time slots, and the maximum computation of the terminal equipment can reach 15 Mbits when the entire working cycle is 30 seconds. Therefore, the algorithm proposed in this study achieves higher computing energy efficiency based on less convergence time and is effective in end-to-end computing power network computing resource scheduling.

New Technique of Intracorporeal Anastomosis and Transvaginal Specimen Extraction for Laparoscopic Sigmoid Colectomy

Wang, Zheng,Zhang, Xing-Mao,Zhou, Hai-Tao,Liang, Jian-Wei,Zhou, Zhi-Xiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Background: Despite the growing acceptance of laparoscopic colon surgery, an abdominal incision is needed to remove the specimen and perform an anastomosis. Recently, natural orifice specimen extraction (NOSE) and intracorporeal anastomosis have been proposed to minimize abdominal wall trauma and improve the quality of laparoscopic colon resections Objective: To evaluate the feasibility and safety of a new approach combining intracorporeal delta-shaped anastomosis and transvaginal specimen extraction for totally laparoscopic sigmoid colectomy. Materials and Methods: Mobilization of bowel and dissection of lymph nodes were performed laparoscopically. After both proximal and distal incisal edges about 10.0 cm distance from sigmoid neoplasm were transected with an Endoscopic Linear Cutter-Straight, a small incision about 1.0 cm was created on the each colon wall of the contralateral side of the mesentery. Then anvils of an Endoscopic Linear Cutter-Straight were inserted into each colon through the small incisions, and incision and anastomosis between the walls of each colon were performed with a linear stapler. A V-shaped anastomosis was made on the wall and the remnant openings was reclosed with the Endoscopic Linear Cutter-Straight. The culdotomy was enlarged with laparoscopic ultrasound dissector. Transvaginal extraction of specimens was accomplished through a wound protector. Results: Surgery was performed for 11 patients with sigmoid cancer. No intraoperative complications or conversions occurred. The mean operating time was 132 min. All the patients were treated laparoscopically without any postoperative complications. Conclusions: The procedures of intracorporeal delta-shaped anastomosis and transvaginal specimen extraction are safe and oncologically acceptable for selected colon cancer cases.

Quantitative Detection of Corroded Reinforced Concrete of Different Sizes Based on SMFL

Mao Yang,Jianting Zhou,Qingyuan Zhao,Qianwen Xia,Hong Zhang,Lifeng Wang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.1

In order to solve the problem of quantitative detection of corroded reinforced concrete of different sizes, the quantitative detection experiment based on spontaneous magnetic flux leakage (SMFL) was carried out in batches. Electrochemical corrosion of 27 reinforced concrete specimens was carried out, and the SMFL signals of reinforcement were obtained by magnetic detection equipment. Four-dimensional magnetic indicators M1-M4 that can characterize the corrosion degree of the specimens were defined. The influence of different sizes on the magnetic indicators were analyzed. It is concluded that the thicknesses of the concrete covers affect the magnetic indicators by affecting the lift-off heights z. The influence of diameter of the rebars on the quantitative detection can be eliminated by describing the corrosion degree with the average cross-section loss rate α. The influence of length of the rebars on quantitative detection is not clear yet. Finally, Support Vector Machine (SVM) was introduced to establish a classification model of corrosion classes and magnetic indicators. Using the model to predict the corrosion classes of the specimens can achieve a high classification accuracy. The research provides a new method for the quantitative detection of steel corrosion.

A New Combined Support Technology to Prevent the Failure of the Existing Metro Station Induced by Unilateral Excavation

Feicong Zhou,Wenhao Fan,Ping Zhou,Mao Chen,Shougen Chen,Zhijie Wang,Yifan Jiang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.3

This study establishes a 3-D simulation model based on a real project, which reveals the problem that the metro structure deformation induced by unilateral excavation without any support exceeds the safety threshold. According to the metro structure deformation warning area, this study proposes a support technology that combines cover plate braces and diagonal steel braces. The research shows that the lateral deformation reduction ratio of the metro station under the diagonal steel brace is about 10% − 20%. The deformation reduction ratio under the cover plate brace is about 35% − 40%. To ensure construction safety, this study adopts the optimal support combination of 3 cover plates and 6+9+11 steel pipes. Monitoring feedback and simulation prediction shows that the comprehensive support system can reduce structural deformation by 56.1%, and effectively control the deformation within a safe range.

A New Iterative LT Decoding Algorithm for Binary and Nonbinary Galois Fields

Yuexin Mao,Jie Huang,Bing Wang,Jianzhong Huang,Wei Zhou,Shengli Zhou 한국통신학회 2013 Journal of communications and networks Vol.15 No.4

Digital fountain codes are record-breaking codes for erasure channels. They have many potential applications in both wired and wireless communications. Most existing digital fountain codes operate over binary fields using an iterative belief-propagation (BP) decoding algorithm. In this paper, we propose a new iterative decoding algorithm for both binary and nonbinary fields. The basic form of our proposed algorithm considers both degree-1 and degree-2 check nodes (instead of only degree-1 check nodes as in the original BP decoding scheme), and has linear complexity. Extensive simulation demonstrates that it outperforms the original BP decoding scheme, especially for a small number of source packets. The enhanced form of the proposed algorithm combines the basic form of the algorithm and a guess-based algorithm to further improve the decoding performance. Simulation results demonstrate that it can provide better decoding performance than the guess-based algorithm with fewer guesses, and can achieve decoding performance close to that of the maximum likelihood decoder at a much lower decoding complexity. Last, we show that our nonbinary scheme has the potential to outperform the binary scheme when choosing suitable degree distributions, and furthermore it is insensitive to the size of the Galois field.