Association Between p16, hMLH1 and E-cadherin Promoter Hypermethylation and Intake of Local Hot Salted Tea and Sun-dried Foods in Kashmiris with Gastric Tumors

Mir, Manzoor R.,Shabir, Nadeem,Wani, Khursheed A.,Shaffi, Sheikh,Hussain, Ishraq,Banday, Manzoor A.,Chikan, Naveed A.,Bilal, S.,Aejaz, Sheikh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

The aim of this study was to evaluate the methylation status of three important cancer related genes viz. p16, E-cadherin and hMLH1 promoters and to associate the findings with specific dietary habits in Kashmiris, a culturally distinct population in India, with gastric cancer. The study subjects were divided into three age groups viz. 0-30yrs ($1^{st}$), 31-60yrs ($2^{nd}$) and 61-90yrs ($3^{rd}$). A highly significant association between the intake of local hot salted tea in $2^{nd}$ (p=0.001) and $3^{rd}$ (p=0.009) age groups was observed with the promoter hypermethylation of E cadherin. Again a highly significant association between the aberrant methylation of hMLH1 (p=0.000) and p16 (p=0.000) promoters and the intake of local hot salted tea was observed in the $2^{nd}$ age group of gastric cancer patients. The intake of sun-dried food was also significantly associated with the promoter hypermethylation of E cadherin (p=0.003) and p16 (p=0.015) genes in $3^{rd}$ age group. The results of the present study suggest a close association between the aberrant methylation of p16, E-cadherin and hMLH1 promoters and the intake of local hot salted tea and sun-dried foods in Kashmiri population.

Caspase-11, the Main Executioner in Non-canonical Inflammasome

Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2012 Journal of Bacteriology and Virology Vol.42 No.2

Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11 rather than caspase-1 is the main offender involved in sepsis. Hence, caspase-11 plays an essential pro-inflammatory role in innate immune response to bacterial infections.

협업 사이버물리시스템의 결함 치명도 분석을 통한 안전성 확보

( Manzoor Hussain ),( Nazakat Ali ),홍장의 ( Jang-eui Hong ) 한국정보처리학회 2021 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.10 No.8

협업 사이버-물리 시스템(Collaborative Cyber-Physical Systems, CCPS)은 물리 세계와 사이버 세계가 밀접하게 결합하여 공동의 목표를 달성하기 위하여 협업을 수행하는 시스템이다. 한편, 단일 사이버-물리 시스템(Cyber-Physical System)의 경우에는 ISO 26262 또는 IEC 61508과 같은 표준을 따르거나 다양한 위험 분석 기법을 적용함으로써 그 안전을 확보할 수 있다. 그러나 CCPS에서는 협업을 수행중인 한 CPS의 결함으로 인하여 다른 협업 중인 CPS에게 수많은 결함을 발생시키기 때문에 안전의 확보가 매우 어렵다. 본 논문에서는 이러한 CCPS의 위험을 분석하여 안전을 확보하기 위해 복합적인 위험 분석과 위험 분석 산출물 사이의 관계를 기반으로 하는 위험 치명도 매트릭스(Fault Criticality Matrix, FCM)를 제시한다. FCM에서는 결함, 결함의 치명도, 안전 가드와 안전 가드의 발생 확률, 결함의 영향 및 순위를 나열하여 분석한다. 안전 엔지니어는 이를 통해 시스템의 설계 단계에서 각 결함의 치명도와 영향을 분석하고, 설계된 안전 가드를 통해 식별된 고장을 효과적으로 관리하고 제어함으로써 안전한 CPS를 개발할 수 있다. 제시된 방법의 유용성을 확인하기 위해 CCPS의 대표적 예인 군집주행에 대하여 사례 연구를 수행하였다. 본 연구에서 개발된 도구를 사용하여 군집주행 시스템에 FCM을 적용함으로써 상세한 결함 치명도 분석을 수행하였고, 분석 결과는 적합성과 효과성 관점에서 점검되었다. 또한 군집 주행에 대한 시뮬레이션 수행을 통해 FCM을 사용하여 결함 치명도를 분석한 군집주행 시스템이 발견된 모든 결함을 완화시켜 충돌 가능성을 크게 낮추었음을 보였다. Collaborative Cyber-Physical Systems (CCPS) are those systems that contain tightly coupled physical and cyber components, massively interconnected subsystems, and collaborate to achieve a common goal. The safety of a single Cyber-Physical System (CPS) can be achieved by following the safety standards such as ISO 26262 and IEC 61508 or by applying hazard analysis techniques. However, due to the complex, highly interconnected, heterogeneous, and collaborative nature of CCPS, a fault in one CPS's components can trigger many other faults in other collaborating CPSs. Therefore, a safety assurance technique based on fault criticality analysis would require to ensure safety in CCPS. This paper presents a Fault Criticality Matrix (FCM) implemented in our tool called CPSTracer, which contains several data such as identified fault, fault criticality, safety guard, etc. The proposed FCM is based on composite hazard analysis and content-based relationships among the hazard analysis artifacts, and ensures that the safety guard controls the identified faults at design time; thus, we can effectively manage and control the fault at the design phase to ensure the safe development of CPSs. To justify our approach, we introduce a case study on the Platooning system (a collaborative CPS). We perform the criticality analysis of the Platooning system using FCM in our developed tool. After the detailed fault criticality analysis, we investigate the results to check the appropriateness and effectiveness with two research questions. Also, by performing simulation for the Platooning, we showed that the rate of collision of the Platooning system without using FCM was quite high as compared to the rate of collisions of the system after analyzing the fault criticality using FCM.

cGAS-cGAMP Signaling and Antiviral Defense

Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2014 Journal of Bacteriology and Virology Vol.44 No.1

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, $cGas^{-/-}$ mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.

Biocontrol Potential of Fungal Endophytes against Fusarium oxysporum f. sp. cucumerinum Causing Wilt in Cucumber

Manzoor Ali Abro,Xiang Sun,Xingchun Li,Ghulam Hussain Jatoi,Liang-Dong Guo 한국식물병리학회 2019 Plant Pathology Journal Vol.35 No.6

Endophytic fungi have received much attention as plant growth promoters as well as biological control agents against many plant pathogens. In this study, 30 endophytic fungal species, isolated from various plants in China, were evaluated using in vitro dual culture assay against Fusarium oxysporum f. sp. cucumerinum, causing wilt in cucumber. The results of the present study clearly showed that all the 30 endophytic fungal isolates were highly capable of inhibiting the mycelial colony growth of Fusarium oxysporum f. sp. cucumerinum with inhibition % over 66% as compared to control treatments. Among all of them, 5 isolates were highly effective such as, Penicillium sp., Guignardia mangiferae, Hypocrea sp., Neurospora sp., Eupenicillium javanicum, and Lasiodiplodia theobromae, respectively. The Penicillium sp. and Hypocrea sp. were highly effective as compared to other isolates. From in vitro results 10 best isolates were selected for greenhouse studies. The results of the greenhouse studies showed that among all of them 3 endophytic fungal isolates successfully suppressed wilt severity when co-inoculation with pathogen Fusarium. oxysporum f. sp. cucumerinum. The endophytic fungi also enhanced plant growth parameters of the host plants, the antagonistic fungal isolates increased over all plant height, aerial fresh, and dry weight as compared to control.

Fault Tolerance by Predictive Fault Prevention System based on Operational Data for Autonomous Vehicles

Manzoor Hussain,Youngjae Kim,Jang-Eui Hong 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.06

Software and services export, IT investment and GDP nexus in India

Manzoor Hassan Malik,Nirmala Velan 경희대학교 글로벌 통상·금융연구원 2019 International Trade, Politics and Development Vol.3 No.2

The purpose of this paper is to investigate both long-run and short-run dynamics among the software and services export, investment in information technology (IT) and GDP in India and to investigate the direction of the relationship among the given three macro-economic variables.The time series data have been taken to investigate the long-run relationship exists among the variables. Annual data were collected from the NASSCOM Annual Reports, Planning Commission of India and Reserve Bank of India during the period 1980–2016. Cointegration and vector error correction model have been used for analyzing the causal relationship among investment in IT, software exports and GDP in India.Cointegration results confirm that software and services export, investment in IT and GDP are cointegrated, implying that there exists the long-run equilibrium relationship among the given three macro-economic variables. Similarly, vector error correction mechanism Granger causality results hold that there is uni-directional long-run causality running from software and services export and investment in IT to GDP, implying that software and services export is an important determinant of economic growth in India.The limitations of the paper are generalization of the results and proxy variable for IT investments.The paper has implications for the expansion of market concentration, diversification of software and service exports, and investments in R&D for increasing competitiveness of the industry in the global market.This paper focuses on originality in the analysis of the relationship among the given variables software exports, investment in the IT sector and GDP in India. All the work has been done in original by the authors and the work used have been acknowledged properly.

Acrosorium polyneurum Extract Inhibits the LPS-Induced Inflammatory Response by Impairing the MAPK and NF-κB Pathways

Manzoor, Zahid,Ali, Irshad,Chae, Doobyeong,Koh, Young-Sang The Korean Society for Microbiology 2016 Journal of Bacteriology and Virology Vol.46 No.4

Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the anti-inflammatory effects of A. polyneurum extract (APE) on pro-inflammatory cytokine production. APE demonstrated substantial inhibitory effects on production of pro-inflammatory cytokine in bone marrow-derived macrophages (BMDMs). APE pre-treatment in the lipopolysaccharide (LPS)-stimulated BMDMs exhibited a robust inhibitory effect on production of interleukin (IL)-12, IL-6 and tumor necrosis factor $(TNF)-{\alpha}$. It revealed a robust inhibitory effect on phosphorylation of ERK1/2, JNK1/2 and p38. APE also showed remarkable inhibitory effect on phosphorylation and degradation of $I{\kappa}B{\alpha}$. Furthermore, APE pre-treatment demonstrated substantial inhibition of LPS-induced production of nitric oxide and inducible nitric oxide synthase. Collectively, these data suggest that APE has a noteworthy anti-inflammatory property and deserve further studies concerning its potential use as a medicinal agent for inflammation-related disorders.

An Update on Gut Microbiota and Infant's Health

Manzoor, Zahid,Koh, Young-Sang The Korean Society for Microbiology 2016 Journal of Bacteriology and Virology Vol.46 No.4

Childhood malnutrition is a global problem and one of the leading cause of stunted growth, and responsible for the death of millions of children every year. Although extensive efforts have been made to promote healthy growth but results are not satisfactory and infant's health remains a challenge. Previously, it was demonstrated that undernourished children have disrupted normal pattern of intestinal microbiota and led to a proposal that it might be involved in impaired postnatal growth. Recently, various research groups focused on Malawian population and proved the role of intestinal microbiota in the stunted growth of children. In addition, one group showed the role of sialylated bovine milk oligosaccharides in promoting microbiota-dependent growth in malnourished children. Moreover, it was also revealed that Clostridium symbiosum and Ruminococcus gnavus might be used as therapeutic agent for ameliorating growth abnormalities in malnourished children. The current article summarizes the recent advancement in identifying interventions regarding health promotion of malnourished children.

Role of zinc oxide nanoparticles in the management of disease complex of beetroot ( Beta vulgaris L.) caused by Pectobacterium betavasculorum , Meloidogyne incognita and Rhizoctonia solani

Manzoor R. Khan,Zaki A. Siddiqui 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.2

The impact of zinc oxide nanoparticles (ZnO NPs) in 100 and 200 mg L −1 concentrations was examined on the hatchingand mortality of M. incognita (Mi) and the growth of P. betavasculorum (Pb) and R. solani (Rs) under in vitro conditions. ZnO NPs inhibited the hatching and caused mortality of 2nd stage juveniles (J2s) of Mi and also inhibited the growth ofPb and Rs. In pot experiments, ZnO NPs in 100 and 200 mg L −1 concentrations were delivered as a foliar spray and seedpriming for the management of disease complex of beetroot. Foliar spray of ZnO NPs to plants infected with pathogens orun-infected more effi ciently improved plant dry mass and physiological and biochemical parameters of beetroot than seedpriming. Foliar spray of ZnO NPs at 200 mg L −1 to plants infected with pathogens resulted in the greatest increase in plantdry mass, and physiological and biochemical parameters of beetroot. Seed priming and foliar spray of ZnO NPs causeda reduction in disease indices, nematode population, and root galling. Foliar spray of ZnO NPs at 200 mg L −1 caused themaximum reduction in disease indices, nematode multiplication, and root galling. The inductively coupled plasma massspectrometry (ICP-MS) analysis revealed that ZnO NPs were accumulated in shoots and roots of both infected and uninfectedplants independent of the application methodology. Overall, the fi ndings suggest that ZnO NPs as the foliar spray has thepotential for the management of root-knot, soft-rot, and root-rot, disease complex of beetroot.