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Yoshinori Matsuoka,Akinori Zaitsu,Makoto Hashizume 연세대학교의과대학 2008 Yonsei medical journal Vol.49 No.3
Purpose: For patients with acute respiratory failure due to lung edema or atelectasis, Surplus lung water that is not removed during an initial stay in the Intensive Care Unit (ICU) may be related to early ICU readmission. Therefore, we performed a retrospective study of patient management during the first ICU stay for such patients. Materials and Methods: Of 1,835 patients who were admitted to the ICU in the 36 months from January, 2003 to December, 2005, 141 were patients readmitted, and the reason for readmission was lung edema or atelectasis in 21 patients. For these 21 patients, correlations were investigated between body weight gain at the time of initial ICU discharge (weight upon discharge from the ICU ÷ weight when entering the ICU) and the time to ICU readmission, between body weight gain and the P/F ratio at ICU readmission, between the R/E ratio (the period using a respirator (R) ÷ the length of the ICU stay after extubation (E)) and the time to ICU readmission, between the R/E ratio and body weight gain, and between body weight gain until extubation and the time to extubation. Results: A negative linear relationship was found between body weight gain at the time of initial ICU discharge and the time to ICU readmission, and between body weight gain at the time of ICU discharge and the P/F ratio at ICU readmission. If body weight had increased by more than 10% at ICU discharge or the P/F ratio was below 150, readmission to the ICU within three days was likely. Patients with a large R/E ratio, a large body weight gain, and a worsening P/F ratio immediately after ICU discharge were likely to be readmitted soon to the ICU. Loss of body weight during the period of respirator support led to early extubation, since a positive correlation was found between the time to extubation and body weight gain. Conclusion: Fluid management failure during the first ICU stay might cause ICU readmission for patients who had lung edema or atelectasis. Therefore, a key to the prevention of ICU readmission is to ensure complete recovery from lung failure before the initial ICU discharge. Strict water management is crucial based on body weight measurement and removal of excess lung water is essential. In addition, an apparent improvement in respiratory state may be due to respiratory support, and such an improvement should be viewed cautiously. Loss of weight at the refilling stage of transfusion prevents ICU readmission and may decrease the length of the ICU stay.
Dramatic Structural Rearrangements in Porous Coordination Networks
Martí,-Rujas, Javier,Islam, Nazrul,Hashizume, Daisuke,Izumi, Fujio,Fujita, Makoto,Kawano, Masaki American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.15
<P>With the use of <I>ab initio</I> X-ray powder diffraction, a family of isostructural crystalline porous coordination networks, [(ZnX<SUB>2</SUB>)<SUB>3</SUB>(TPT)<SUB>2</SUB>]<SUB><I>n</I></SUB>· (solvent) (X = I, Br, Cl), has been studied at elevated temperatures of 573−723 K. Upon heating, all three networks exhibited crystalline-to-amorphous-to-crystalline (CAC) phase transformations to three new networks, [(ZnI<SUB>2</SUB>)<SUB>3</SUB>(TPT)<SUB>2</SUB>]<SUB><I>n</I></SUB>, [(ZnBr<SUB>2</SUB>)<SUB>3</SUB>(TPT)<SUB>2</SUB>]<SUB><I>n</I></SUB>·(H<SUB>2</SUB>O) and [(ZnBr<SUB>2</SUB>)(μ-Br)(ZnBr)(TPT)]<SUB><I>n</I></SUB>, and [(ZnCl<SUB>2</SUB>)(μ-Cl)(ZnCl)(TPT)]<SUB><I>n</I></SUB>, respectively. A set of control experiments was used to obtain detailed mechanistic aspects of the CAC transformations. We demonstrate how bonds are broken and formed in these significant molecular rearrangements and how the initial arrangement plays a crucial role in the formation of the new networks after the CAC transformations. The structural information in the amorphous phase is retained and passed from a metastable to a more stable crystal, thus, reinforcing the notion that coordination networks are flexible and chemically active.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-15/ja109160a/production/images/medium/ja-2010-09160a_0014.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja109160a'>ACS Electronic Supporting Info</A></P>
Cho, Byunghyun,Lee, Hee-Ho,Shin, Jang-Kyoo,Murata, Masaharu,Ohuchida, Kenoki,Hashizume, Makoto National Taiwan University 2012 Biomedical engineering Vol.24 No.2
<P> In this paper, we assess the feasibility of detecting human pancreatic cancer cells using a field effect transistor (FET)-based biosensor with an extended Au gate for medical application. Pancreatic cancer is one of the most fatal cancers, and is very difficult to diagnose in its early stages. Gemcitabine is an anticancer drug, and when used in chemotherapy it induces cell death. During apoptosis, the surface potential of the pancreatic cancer cells is changed by gemcitabine. In the present study, this change was detected using an FET-based biosensor. This biosensor was fabricated with an extended Au gate, whose surface is a sensing area for cancer cells. A null-balancing circuit was used in the measurement system, and the LabVIEW software platform allowed the immune-reaction at the Au gate to be detected as an output voltage. The cancer cells were incubated for one day; during this time, the cancer cells adhered to the Au extended gate surface. As gemcitabine was introduced to the cancer cells in vitro, changes in the output of the biosensor were monitored. Pancreatic cancer cells with a resistance to gemcitabine were used to verify that the change in the output of the biosensor was due only to the interaction between the cancer cells and the gemcitabine. We also investigated the relationship between the starting time of the reaction and the concentration of the anticancer drug. </P>
Martí,‐,Rujas ,, Javier,Islam, Nazrul,Hashizume, Daisuke,Izumi, Fujio,Fujita, Makoto,Song, Hyun Jae,Choi, Hee Cheul,Kawano, Masaki WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.27
<P><B>Synchrotron‐Pulver‐XRD</B>‐Analysen führten zur Kristallstruktur eines unter kinetischer Kontrolle gebildeten Koordinationspolymers mit großer Elementarzelle (15 729(1) Å<SUP>3</SUP>). In den Poren dieses Gerüsts sind Tetrathiafulvalenmoleküle mit kleinen S<B>⋅⋅⋅</B>S‐Abständen eingeschlossen (siehe Bild).</P>
Warning navigation system using real-time safe region monitoring for otologic surgery.
Cho, Byunghyun,Oka, Masamichi,Matsumoto, Nozomu,Ouchida, Riichi,Hong, Jaesung,Hashizume, Makoto Springer Science + Media 2013 International journal of computer assisted radiolo Vol.8 No.3
<P>We developed a surgical navigation system that warns the surgeon with auditory and visual feedback to protect the facial nerve with real-time monitoring of the safe region during drilling.</P>
Fusarisetin A, an Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326
Jang, Jae-Hyuk,Asami, Yukihiro,Jang, Jun-Pil,Kim, Sun-Ok,Moon, Dong Oh,Shin, Kee-Sun,Hashizume, Daisuke,Muroi, Makoto,Saito, Tamio,Oh, Hyuncheol,Kim, Bo Yeon,Osada, Hiroyuki,Ahn, Jong Seog American Chemical Society 2011 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.133 No.18
<P>An acinar morphogenesis inhibitor named fusarisetin A (<B>1</B>) that possesses both an unprecedented carbon skeleton and a new pentacyclic ring system has been identified from an in-house fractionated fungal library using a three-dimensional matrigel-induced acinar morphogenesis assay system. The structure of <B>1</B> was determined in detail by NMR and circular dichroism spectroscopy, X-ray analysis, and chemical reaction experiments.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-18/ja1110688/production/images/medium/ja-2010-110688_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja1110688'>ACS Electronic Supporting Info</A></P>