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추성욱,김경남,김광만,이원유,박용수,이상배 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.3
Esthetic has become an indispensable factors to consider when choosing a orthodontic fixed appliances. However, most of the brackets used on orthodontics are made of metallic materials because those esthetic alternatives showed several controversies like brittleness, deformation and discoloration. The AISI austenitic classes, 303, 304, 316 and 317 type of stainless steels are frequently used for orthodontic metallic brackets fabrication. The composition of this type of alloy is 18 wt% of chrome, 8 wt% of nickel, 2 to 3 wt% of molybdenum and low carbon contents. They seemed to show relatively good characteristics to fabricate the orthodontic brackets in previous study. But in hostile condition such as low pH containing chlorine ion like saliva they might to be attacked by localized corrosion. The purposes of this study were to evaluate the microstructure, microhardness, corrosion resistance, frictional resistance and cytotoxocity of 316L(MD), AISI 304(AC) and experimentally produced super stainless stell bracket(SS). The results from this study were as follows; 1. MD and AC showed (Cr, Fe)23C6 precipitating in austenite matrix. SS showed small ferrite island forming in matrix. 2. SS showed the highest polarization resistance(Rp). SS seemed to have the highest corrosion resistance since SS showed 0.9 ×10-3 MPY, MD showed 3.7 ×10-3 MPY and AC showed 7.4×10-3 MPY. 3. The friction resistance decreased from 3 days to 4 weeks for SS(p<0.05). MD showed significant differences for the measurement of 3 days, 2 weeks and 4 weeks. AD did not showed significant differences to 3 days but increased at 2 weeks(p<0.05). 4. SS seemed to have the best biocompatibility since SS showed response index of 0/1 (mild), AC showed 1/2 (mild+) at cytotoxicity test. According to these results, SS seemed to have sufficient characteristics to fabricate the orthodontic brackets and superior corrosion resistance compare to AISI 300 type stainless steel which could lower the chance of nickel allergic reaction.
Rocuronium의 애별투여방법이 모지내전근의 이완에 미치는 영향
최영균,김승수,이원진,조광래,이상은,김영환,임세훈,이정한,이근무,정순호,김영재,신치만 인제대학교 2009 仁濟醫學 Vol.30 No.-
Objective : There are controversies in pnmmg technique of rocuronium whether it can or can't shorten the onset time. We want to compare the effects of two different priming doses and intervals of rocuronium. Materials and Methods : After giving propofol, 50 patients were randomly assigned to 5 groups. Group I received a placebo, followed 3 min later by rocuronium 0.6 mg/kg. Priming doses and intervals of Group II, Ill, N, V were 0.06 rng/kg and 2 min, 0.12 mg/kg and 2 min, 0.06 rug/kg and 3 min, 0.12 mg/kg and 3 min, respectively. Total dose of rocuronium was 0.6mg/kg. Train of four (TOF) count or ratio and 1st twitch height of TOF (T1) were monitored with 15 secondsintervals. TOF ratio of each groups just before bolus injection, duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were compared. Results : Duration for TOF count to reach zero and duration for Tl to reach 95% depression after bolus injection were decreased in priming groups compared to Group 1 (P < 0.01) In group V, significant depression of TOF ratio just before bolus injection was seen (P < 0.05). Conclusion : Priming technique with rocuronium is effective method to shorten the onset of neuromuscular block. But priming dose of rocuronium itself could cause hypoxia and aspiration in awake patients and should be used carefully. Priming dose of rocuronium 0.06 mg/kg and 2 minutes interval maybe relatively safe method.
Case Report : Uncontrollable hyperthermia in acute cerebral injury
Won Jin Lee,Young Hwan Kim,Seung Su Kim,Kwang Rae Cho,Sang Eun Lee,Se Hun Lim,Jeong Han Lee,Kun Moo Lee,Soon Ho Cheong,Young Kyun Choe,Young Jae Kim,Chee Mahn Shin 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.3
A 39 year old man arrived at the hospital with semi-comatose state as a result of spontaneous intracerebral hemorrhage (ICH), intraventricular hemorrhage (IVH) and subarachnoid hemorrhage (SAH). For emergency craniectomy and hematoma removal, general anesthesia with desflurane and vecuronium was planned. Before the induction of anesthesia, the body temperature and end-tidal carbon dioxide (ETCO2) levels were 38.3℃ and 38 mmHg, respectively. The body temperature and ETCO2 increased during surgery. After 2 hours of anesthesia, the temperature had increased to 41℃, despite bladder irrigation and body cooling. After 3 hours of anesthesia, the temperature reached 43.5℃ and cardiac arrest developed. Cardiopulmonary resuscitation was attempted, but the patient expired. (Korean J Anesthesiol 2009;57:392∼4)
Kim, Dong Eon,Jang, Mi-Jin,Kim, Young Ran,Lee, Joo-Young,Cho, Eun Byul,Kim, Eunha,Kim, Yeji,Kim, Mi Young,Jeong, Won-il,Kim, Seyun,Han, Yong-Mahn,Lee, Seung-Hyo Elsevier 2017 Toxicology Vol.387 No.-
<P><B>Abstract</B></P> <P>Drug-induced liver injury (DILI) is a leading cause of liver disease and a key safety factor during drug development. In addition to the initiation events of drug-specific hepatotoxicity, dysregulated immune responses have been proposed as major pathological events of DILI. Thus, there is a need for a reliable cell culture model with which to assess drug-induced immune reactions to predict hepatotoxicity for drug development. To this end, stem cell-derived hepatocytes have shown great potentials. Here we report that hepatocyte-like cells derived from human embryonic stem cells (hES-HLCs) can be used to evaluate drug-induced hepatotoxic immunological events. Treatment with acetaminophen significantly elevated the levels of inflammatory cytokines by hES-HLCs. Moreover, three human immune cell lines, Jurkat, THP-1, and NK92MI, were activated when cultured in conditioned medium obtained from acetaminophen-treated hES-HLCs. To further validate, we tested thiazolidinedione (TZD) class, antidiabetic drugs, including troglitazone withdrawn from the market because of severe idiosyncratic drug hepatotoxicity. We found that TZD drug treatment to hES-HLCs resulted in the production of pro-inflammatory cytokines and eventually associated immune cell activation. In summary, our study demonstrates for the first time the potential of hES-HLCs as an <I>in vitro</I> model system for assessment of drug-induced as well as immune-mediated hepatotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Generation and characterization of hES-HLCs for evaluation of drug-induced immune cell-mediated hepatotoxicity. </LI> <LI> The secretion of inflammatory cytokines is highly enhanced from APAP-treated hES-HLCs. </LI> <LI> Immune cells are activated and produce pro-inflammatory cytokines by conditioned medium from hES-HLCs cultured with APAP. </LI> <LI> Hepatotoxic results in hES-HLCs are consistent with those of primary human hepatocytes. </LI> <LI> Hepatotoxic drugs such as TZD, and non-hepatotoxic drugs such as aspirin and metformin, are also validated with our drug screening system. </LI> </UL> </P>
Park, Mahn-Won,Her, Sung Ho,Kim, Ho-Sook,Choi, Yun-Seok,Park, Chul-Soo,Koh, Yoon-Seok,Park, Hun-Jun,Kim, Pum-Joon,Kim, Chan Joon,Jeon, Doo Soo,Shin, Dong Il,Seo, Suk Min,Yoo, Ki-Dong,Kim, Dong Bin,Kim Wolters Kluwer Health | Lippincott Williams Wilkin 2013 Pharmacogenetics and genomics Vol.23 No.10
The impact of the CYP2C19*17 polymorphism on the clinical outcome in Asians undergoing percutaneous coronary intervention (PCI) is unknown. We sought to assess the long-term impact of CYP2C19*17 on the risk for adverse clinical events in 2188 Korean patients taking clopidogrel after PCI. The prevalence of the CYP2C19*17 allele [*wt/*17: 2.4% (n=53), *17/*17: 0%] was very low. The 2-year cumulative event rates for bleeding [*wt/*17 vs. *wt/*wt: 2 vs. 2.3%; adjusted hazard ratio (HR), 1.23; 95% confidence interval (CI), 0.16–9.45], stent thrombosis (2 vs. 1.1%; HR, 3.98; 95% CI, 0.49–31.6) or composite of any death, and myocardial infarction or stroke (5.4 vs. 7.1%; HR, 1.37; 95% CI, 0.32–5.73) did not differ on the basis of the presence of CYP2C19*17. In conclusion, in our study population of Asian patients, the CYP2C19*17 polymorphism was not associated with adverse clinical outcomes after PCI because of its low prevalence, the rarity of homozygotes, and the relatively low rate of adverse clinical events.
백두대간 생태 복원을 위한 시민참여 프로그램 개발과 적용
김찬국(Kim Chankook),안동만(Ahn Tong Mahn),김인호(Kim In Ho),이재영(Le Jae Young),김성진(Kim Sung Jin),채혜성(Chae Hye Sung),이영(Lee Young),이재원(Lee Jae Won),김민우(Kim Min Woo),신민종(Shin Min Jong),박효인(Park Hyo In),조경준(Cho K 한국환경교육학회 2010 環境 敎育 Vol.23 No.2
Ecological restoration aims to reverse the degradation of ecosystems that occurred as humans have affected landscapes. This study was conducted in part of a larger project to develop participatory ecological restoration procedures for disturbed areas in Baigdoodaegahn which is a major mountain range in the Korean Peninsula. The case of alpine farmland at Kangwon-do was selected to apply the theoretical framework of participatory restoration since the nutrient contents in alpine solid under vegetable cultivation degrade water quality in the watershed while farmers in the region are economically struggling due to imports of vegetables from China. The reciprocal model of restoration was applied to cope with interactions between human and ecosystem needs in ecological restoration. A series of environmental education and eco-tourism programs were developed and incorporated into the participatory restoration project to rebuild social-cultural aspects of the community as well as to restore the biophysically disturbed area while meeting both ecological needs and human needs. This study suggests that participatory projects will be more successful when experts support the local residents and citizens in restoration process, when leadership are developed through social learning, and when ecological, financial and social factors of restoration are integratedly considered.
Young Choi,Mahn-Won Park,Sung Ho Her,Chan Joon Kim,Jung Sun Cho,Gyung-Min Park,Tae-Seok Kim 조선대학교 의학연구원 2014 The Medical Journal of Chosun University Vol.39 No.4
Treatment of spontaneous retroperitoneal hemorrhage (SRH) is mainly conservative. However, if intra-abdominal hypertension (IAH) or abdominal compartment syndrome (ACS) develops, the treatment strategy should be more aggressive. Surgical decompression has been the gold standard; however, it is very invasive and highly morbid. Thus, percutaneous catheter drainage (PCD) has been introduced as an alternative therapeutic option. We report on a case of successful PCD for prevention of progression of IAH to ACS in a patient with SRH after coronary stent implantation. This case showed that PCD can be an efficacious and safe method for treatment of IAH with impending ACS.