Oral Administration of Novel Oriental Medicine, KIOM-C, Protect against Influenza Virus

Jin Yeul Ma, Eun Ha Kim, Jun Han Lee, Min-Suk Song, Yun Hee Baek, Young Ki Choi 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

The influenza virus is an important respiratory risk affecting humans, and effective treatments are needed. Some oriental medicines are currently applied for treatment of common colds as well as influenza infection. Previous studies have reported that the therapeutic properties of MA-128 are effective for treatment of psoriasis antiasthmatic and atopic dermatitis. In this study, we investigated the therapeutic properties of the novel herbal medicine, MA-128, for treatment of influenza virus infection by oral administration. MA-128 is an active natural biological compound from herbal-marine origin. The results showed that oral administration of MA-128 in mice could confer a survival benefit against Type A influenza virus infection. Daily oral administration of MA- 128 resulted in delayed death in infected mice for three days against mouse adapted H3N2 (A/Philippines/2/82). However, it protected more than 60% of mice from lethal infection of 2009 pandemic H1N1 (A/Korea/CJ01/2009) influenza virus. In addition, lung viral titers were significantly reduced at seven days post infection (~100 times) compared with mock-treated mice and viruses were cleared at 9 dpi only in the MA-128 treated groups. This study demonstrated the potential of the novel herbal medicine, MA-128, as an herbal remedy against influenza A viruses.

문서에서의 구문적 오류 검출

김진우,마상백,김한우 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1

본 논문은 기존의 철자 검사기로는 검출해 내지 못했던 구문 오류 일부를 검출해 낼 있는 방법을 제시한다. 일반적으로 문서작업을 할 때의 오타입력은 주로 자판 입력시 주위 문자를 잘못 입력하는 경우의 오류가 대부분이다. 이러한 오류 단어가 형태소 분석에 실패하는 경우는 철자 오류검사로도 교정이 되지만 형태소 분석을 성공한 경우에는 검출이 불가능하다. 따라서 형태소 분석을 통과한 오류 단어를 발견하는 방법을 제안한다. 이 방법은 특정 단어를 자소 대치를 한 후 다른 단어와 비교하여 오류일 확률이 낮은 단어와 매칭이 된다면 일단 오류 후보로 가정한다는 것이다. 여기에는 일부 휴리스틱한 제약이 필요하다. 이 단어간 비교에 의한 추정은 전에 발견하지 못했던 구문 오류 일부를 발견할 수 있게 해준다. In a typed document, spelling errors are cause of word errors. Traditional Critiquing system like a spelling checker detects spelling error using a morphological analyser. If morphological analyser detected a certain error word, it could also correct the error word. In other case, spelling checker can not detect a error word. In this paper, a method that can detect additional syntactic errors by comparing words in a document is proposed. The method is based on word errors appearing frequently in typist's misspelling using word processor. In this the method, a certain word is changed by one-letter substitution, and the changed word is compared with errors of low possibility words in a document. If the changed word matches errors of low possibility words, this method deduces that the word is the error of high possibility word. The method has to be added with various heuristic restrictions. The Deduction Using Words Comparison' method can detect additional syntactic errors.

Polysaccharide from Polygonatum Inhibits the Proliferation of Prostate Cancer-Associated Fibroblasts Cells

Han, Shu-Yu,Hu, Ming-Hua,Qi, Guan-Yun,Ma, Chao-Xiong,Wang, Yuan-Yuan,Ma, Fang-Li,Tao, Ning,Qin, Zhi-Hai Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8

Inhibition of cancer-associated fibroblasts (CAFs) may improve the efficacy of cancer therapy. Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (p<0.001) without inhibiting the growth of normal fibroblasts (NAFs). Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs. 3-methyl-adenine(3-MA) is an autophagy inhibitor. 3-MA was added to prostate-CAFs with polysaccharide from polygonatum to determine whether autophagy plays an important role in the restrained effect. Finally, polysaccharide from polygonatum treatment significantly increased the activation of Beclin-1 and LC3, key autophagy proteins. Polysaccharide from polygonatum stimulates autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate-CAFs.

Genetic Variants at 6p21.1 and 7p15.3 Identified by GWASs of Multiple Cancers and Ovarian Cancer Risk: a Case-control Study in Han Chinese Women

Li, Da-Ke,Han, Jing,Liu, Ji-Bin,Jin, Guang-Fu,Qu, Jun-Wei,Zhu, Meng,Wang, Yan-Ru,Jiang, Jie,Ma, Hong-Xia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

A recent study summarized several published genome-wide association studies (GWASs) of cancer and reported two pleiotropic loci at 6p21.1 and 7p15.3 contributing to multiple cancers including lung cancer, noncardia gastric cancer (NCGC), and esophageal squamous-cell carcinoma (ESCC) in Han Chinese. However, it is not known whether such genetic variants have similar effects on the risk of gynecologic cancers, such as ovarian cancer. Hence, we explored associations between genetic variants in 6p21.1 and 7p15.3 and ovarian cancer risk in Han Chinese women. We performed an independent case-control study by genotyping the two loci (rs2494938 A > G at 6p21.1 and rs2285947 A > G at 7p15.3) in a total of 377 ovarian cancer cases and 1,034 cancer-free controls using TaqMan allelic discrimination assay. We found that rs2285947 at 7p15.3 was significantly associated with risk of ovarian cancer with per allele odds ratio (OR) of 1.33 [95% confidence interval (CI): 1.08-1.64, P=0.008]. However, no significant association was observed between rs2494938 and ovarian cancer risk. Our results showed that rs2285947 at 7p15.3 may also contribute to the development of ovarian cancer in Han Chinese women, further suggesting pleiotropy of 7p15.3 in multiple cancers.

Slide Session : OS-GAS-02 ; Gastroenterology : Application of Machine Learning Techniques for Clin-ical Predictive Modeling: A Cross-Sectional Study on Nonalcoholic Fatty Liver Disease

( Han Ma ),( Chengfu Xu ),( Zhe Shen ),( Chaohui Yu ),( Youming Li ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Recent attention focuses on screening and prediction of NAFLD. Machine learning techniques are powerful and promising tools. Methods: A cross-sectional study was performed among 10,508 subjects who attended their annual health examination in the first affiliated hospital, College of Medicine, Zhejiang University, China in 2010. The questionnaires, Physical examinations, laboratory tests and liver ultrasonography were performed. 20 features (e.g., age, laboratory results) were extracted. Machine learning techniques were implemented on the open source software named Weka. The tasks included feature selection and classification. By removing redundant features, feature selection techniques built a screening model. Classification was used to build a prediction model, which was evaluated by F measure. Nine machine learning techniques were investigated, i.e., logistic regression, K-Nearest Neighbor, Support Vector Machine, naive Bayes, Bayesian network, decision tree, Adaboosting, bagging, and random forest. Results: A total of 2522(24%) subjects were fulfilled the diagnostic criteria of NAFLD. By using feature selection techniques, BMI, serum triglyceride, ALT, GGT and uric acid were the top-5 features contributing most to NAFLD. 10-fold cross-validation was used in classification to evaluate machine learning techniques, i.e., subjects were randomly divided into 10 folds, 9 folds were used to build a prediction model, the remaining fold was used to evaluate. The whole process lasted for 10 times, average performance was recorded. The results showed among the nine state-of-the-art machine learning techniques, Bayesian network demonstrated the best performance. It achieves the accuracy, specificity, sensitivity, and F-measure scores up to 83%, 0.787, 0.678, and 0.665, respectively. Compared with logistic regression, Bayesian network improves F-measure score by 10.83%. Conclusions: Novel machine learning techniques may have screening and predictive value for NAFLD.

Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media

Han, Seung Beom,Kim, Jong-Hyun,Kang, Jin Han,Ma, Sang Hyuk,Kim, Chun Soo,Kim, Kyung-Hyo,Kim, Hwang Min,Choi, Young Youn Elsevier 2017 Journal of infection and chemotherapy Vol.23 No.3

<P>Conclusion: S. pneumoniae serotype 19A, serogroups 11 and 15 were the major nasopharyngeal-colonizing bacteria in Korean children with AOM after the introduction of PCV7. These relatively prevalent serotype/serogroups showed lower antibiotic susceptibility rates. (C) 2016 Published by Elsevier Ltd on behalf of Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.</P>

Macelignan Attenuates Activations of Mitogen-Activated Protein Kinases and Nuclear Factor kappa B Induced by Lipopolysaccharide in Microglial Cells

Ma, Jinhua,Hwang, Yoo Kyeong,Cho, Woo-Hyun,Han, Seol-Heui,Hwang, Jae Kwan,Han, Jung-Soo Pharmaceutical Society of Japan 2009 Biological & pharmaceutical bulletin Vol.32 No.6

<P>A previous study showed that macelignan extracted from <I>Myristica fragrans</I> has anti-inflammatory properties using hippocampal neuronal and primary microglial cells. Subsequently, a study using animals with chronic lipopolysaccharide (LPS) infusion into the brain showed that oral treatments of macelignan reduced the hippocampal microglial activation and hippocampal-dependent spatial memory impairments induced by LPS. However, the molecular mechanisms responsible for the anti-inflammatory activity of macelignan have not been elucidated in the microglia. Therefore, the present study was conducted to determine if mitogen-activated protein kinase (MAPK) signaling and nuclear factor-kappa B (NF-κB) activities are related to the anti-inflammatory effects of macelignan on LPS-stimulated BV-2 microglial cells. The results show that macelignan suppresses both the phosphorylations of MAPKs and the degradation of inhibitory-kappa B (IκBα) and increases of nuclear NF-κB in LPS-stimulated BV-2 microglial cells. These results suggest that macelignan has an anti-inflammatory effect on the affected brain through regulation of the inflammation through the MAPK signal pathway.</P>

Identification of quantitative trait loci associated with drought tolerance traits in rice (Oryza sativa L.) under PEG and field drought stress

Han, Bing,Wang, Jiao,Li, Yafei,Ma, Xiaoding,Jo, Sumin,Cui, Di,Wang, Yanjie,Park, Dongsoo,Song, Youchun,Cao, Guilan,Wang, Xingsheng,Sun, Jianchang,Shin, Dongjin,Han, Longzhi Springer Netherlands 2018 Euphytica Vol.214 No.4

Case Reports : Rosai-Dorfman Disease with Massive Cutaneous Nodule on the Shoulder and Back

( Han Ma ),( Yue Zheng ),( Guoxing Zhu ),( Jie Wu ),( Chun Lu ),( Wei Lai ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.1

Rosai-Dorfman disease is a rare, idiopathic, benign, andself-limiting histiocytic proliferative disorder. A 26-year-oldman presented with a single massive cutaneous nodule(reaching 30 cm in diameter) on the left shoulder and back for15 months. The routine hematological and biochemical testswere normal. Magnetic resonance scanning showed the lesioninvolved the skin, subcutaneous tissue, and subjacent musclegroup, accompanied by obvious lymph node enlargement inthe left part of the neck, supraclavicular fossa, and axillaryfossa. The histopathology of the left cervical lymph noderevealed diffuse effacement of the normal nodal architecture,with patchy chronic inflammatory cell infiltrates comprisinglymphocytes and sheets of histiocytes. Some histiocytescontained lymphocytes within their pale cytoplasm. Manymultinucleated giant cells were found; however, caseatinggranulomas were not seen. The skin and muscle biopsyspecimen obtained from the back revealed infiltratinglymphocytes and histiocytes diffusely distributed in thedermis, subcutaneous tissue, and crevices of the muscle fibers. The phenomenon of emperipolesis and the presence ofmultinucleated giant cells were also seen. Immunohistochemicalstaining revealed that the histiocytes were positivefor S-100 protein and CD68 but negative for CD1a. Immunophenotyping of the infiltrating lymphocytes indicatedpositive reactions to CD3, CD45RO, CD5, CD7, CD4, CD8(partly), CD79a, CD20 (partly), and Ki-67 (<1%). The finaldiagnosis was Rosai-Dorfman disease. Owing to the extensiveand deep involvement of the subcutaneous tissue and muscles,the patient did not undergo surgery to excise the massive skinnodule. The lesion showed no obvious change at the 12-monthfollow-up. (Ann Dermatol 27(1) 71∼75, 2015)

Fluridone affects quiescent centre division in the Arabidopsis thaliana root stem cell niche

( Woong Han ),( Han Ma Zhang ),( Myeong Hyeon Wang ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.12

Plants undergo cell division throughout their life in order to maintain their growth. It is well known that root and shoot tip of plants possess meristems, which contain quiescent cells. Fluridone (1-methyl-3-phenyl-5-(3-trifluromethyl (phenyl))-4-(1H)-pyridinone) is an established inhibitor of both ABA and carotenoid biosynthesis. However, the other functions of fluridone remain undiscovered. In this report, we provide experimental evidence that fluridone plays a role in the division of the quiescent centre of the Arabidopsis root meristem. This study examined the effects of exogenous fluridone and ABA on the development of the stem cell niche in Arabidopsis root. We show that fluridone promoted the division of stem cells in the quiescent centre, whereas exogenous ABA suppressed quiescent centre division. Furthermore, we established a novel regulatory function for fluridone by demonstrating that it plays an important role in postembryonic development. [BMB reports 2010; 43(12): 813-817]