Flavobacterium columnare / Myxobolus tilapiae Concurrent Infection in the Earthen Pond Reared Nile Tilapia (Oreochromis niloticus) during the Early Summer

Eissa, Alaa E.,Zaki, Manal M.,Aziz, A. Abdel Korean Society for Bioinformatics 2010 Interdisciplinary Bio Central (IBC) Vol.2 No.2

Flavobacterium columnare (F. columnare), the dermotropic Gram negative yellow pigmented bacteria was isolated from different sites of skin ulcerations in the Nile tilapia (Oreochromis niloticus) and Nile catfish (Clarias gariepinus) collected from an earthen pond located at an aquaculture station in Sharkiya Province, Lower Egypt during an acute episode of mass kills during the early summer of 2009. An acute infection with F. columnare was behind the emergent event of mass mortalities among both populations. Many of the Nile tilapias exhibited typical signs of hole - in- the head like lesions from which F. columnare together with the myxosporean spore, Myxobolus tilapiae (M. tilapiae) were retrieved. Most of the cohabitating infected Nile catfishes exhibited severe form of saddle back like ulcer. The identities of the retrieved isolates were confirmed using morphological, biochemical and molecular tools. The research lead us to conclude that the two diverse etiological agents (F. columnare and M. tilapiae) under the triggering effect of the abrupt change in the water quality measures (abrupt rise in the water temperature, ammonia, pH, sharp decrease in dissolved oxygen) have synergized together to induce the above mentioned pathology with the consequent reemergence of fish mass mortalities.

Assessing the genotoxicity of oral zinc oxide nanoparticle administration in male rats using micronuclei and comet assay

Amal G. Ramadan(Amal G. Ramadan ),Ahmed A. M. Yassein(Ahmed A. M. Yassein ),Eissa A. Eissa(Eissa A. Eissa ),Gamal M. Hassan(Gamal M. Hassan ) 한국축산식품학회 2022 Food and Life Vol.2022 No.3

Zinc oxide nanoparticles (ZnO-NPs) are regularly utilized in the food and fertilizers industries. In our investigation, rats received oral administration of ZnO NPs with a particle size of 30±5 nm once daily at doses of 100, 200, 300, 400, and 600 mg/kg for ten weeks in order to assess the genotoxic effect. Impacts on hematological markers, genotoxic impact, and growth were investigated. The findings showed that ZnO-NPs significantly reduced body weight gain, red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit value (HCT), and platelet count (PLT), while increasing white blood cell (WBC), mean capsular volume (MCV), mean capsular hemoglobin (MCH), and mean capsular hemoglobin concentration (MCHC) in the treated rats. Our results for the comet assay and micronuclei test show a dosage-dependent increase in DNA fragmentation, which was supported by an increase in the percentage of DNA that is tailed, the length and intensity of DNA tails, and the tail moment, especially at the dose of 600 mg/kg. According to the findings, the frequency of micronucleated cells has increased.

Synthesis and Biological Evaluation of Some New2-propyl- 4(3H)-Quinazolinone Derivatives as Anti-bacteria

Eissa, A.M.F.,El-metwally, A.M.,El-hashash, M.A.,El-gohary, A.M.F. Korean Chemical Society 2008 대한화학회지 Vol.52 No.3

Safety and Efficacy of Mini Open Transforaminal Lumbar Interbody Fusion

Mohamed M. Mohi Eldin,Ehab M. Eissa,Haitham M. Elmorsy 대한척추신경외과학회 2016 Neurospine Vol.13 No.4

Objective: Mini-transforaminal lumbar interbody fusion (Mini-TLIF) and other minimally invasive approaches introduced for the purpose of treating lumbar degenerative disc disease and instability are achieving high success and safety rates as the conventional approaches. Moreover, it has less soft tissue damage, minimal blood loss, and less hospital stay. Methods: A prospective study was conducted from 2012 to 2014 on 28 patients who were subjected to Mini-open TLIF combined with transpedicular screw fixation for spondylolisthesis and degenerative disc disease. Two paramedian approaches were done, 4 cm for each, to insert the pedicular screws, along with inserting unilateral TLIF cage with autologous bone graft. Decompression was done either unilateral or bilateral according to the patient side of radiculopathy. Sixteen patients (57.2%) were diagnosed with degenerative spondylolisthesis, 7 patients (25%) were diagnosed with isthmic type spondylolisthesis, and 5 patients (17.8%) were diagnosed with degenerative disc disease, 2 of them(7.1%) had previous operations at the same level. Twenty patients (71.4%) were operated at the L4/5 level, and 8 patients (28.6%) at the L5/S1 level. Results: All patients were able to ambulate the next day of surgery. The mean estimated blood loss was 251.79mL. The average hospital stay was 4.14 days. The average follow-up was 9 months. The mean visual analog scale was 1.86 at discharge, 1.68 after 3 months, and 1.38 after 6 months. After 6 months of the operation, MacNab’s criteria were good in 23 patients and excellent in 5 patients. We had one case with transient weakness, 2 cases of screw malposition without clinical manifestations, and one case of infection. Conclusion: Mini-TLIF approach is an efficient and safe approach for treating instability and degenerative diseases of the lumbar spine. The clinical outcome is encouraging and it may be an operation of choice for lumbar spinal fusion in selected patients.

Synthesis and Anti-inflammatory Activity of Novel Pyridazine and Pyridazinone Derivatives as Non-ulcerogenic Agents

Makarem M. Saeed,Eman M. Ahmed,Nadia A. Khalil,Kholoud I. Eissa 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12

Herein, we report the synthesis and pharmacological properties of several series of pyridazine and pyridazinone derivatives. All the synthesized compounds were tested, in vivo, for their anti-inflammatory and ulcerogenic properties against indomethacin, as a reference compound. Compounds 4a and 9d have shown a potent anti-inflammatory activity more than indomethacin with rapid onset of action and safe gastric profile. The latter compounds were then selected for further investigation. In the MTT assay in vitro, both compounds were identified as potent and selective COX-2 inhibitors.

Distinct Properties of Tungsten Austenitic Stainless Alloy as a Potential Nuclear Engineering Material

E. Salam,M.M. Eissa,A.S. Tageldin 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.3

In the present study, a series of tungsten austenitic stainless steel alloys have been developed byinterchanging the molybdenum in standard SS316 by tungsten. This was done to minimize the long-liferesidual activation occurred in molybdenum and nickel after decommissioning of the power plant. Themicrostructure and mechanical properties of the prepared alloys are determined. For the sake ofincreasing multifunction property of such series of tungsten-based austenitic stainless steel alloys,gamma shielding properties were studied experimentally by means of NaI(Tl) detector and theoreticallycalculated by using the XCOM program. Moreover, fast neutrons macroscopic removal cross-section beencalculated. The obtained combined mechanical, structural and shielding properties indicated that themodified austenitic stainless steel sample containing 1.79% tungsten and 0.64% molybdenum has preferableproperties among all other investigated samples in comparison with the standard SS316. Theseproperties nominate this new composition in several nuclear application domains such as, nuclearshielding domain.

The Liquidity of Indian Firms: Empirical Evidence of 2154 Firms

AL-HOMAIDI, Eissa A.,TABASH, Mosab I.,AL-AHDAL, Waleed M.,FARHAN, Najib H.S.,KHAN, Samar H. Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.1

This paper aims to empirically study the determinants of liquidity of Indian listed firms. To account for profit persistence, we apply a (pooled, fixed and random) effect models to a panel of Indian listed firms that covers the time period from 2010 to 2016. This study consists of 2154 firms operating in Indian market. Liquidity (LQD) of Indian firms is measured by liquid assets to total assets, whereas bank size, capital adequacy, profitability, leverage, and firm age are used as internal determinants. Further, economic activity, inflation rate, exchange rate, and interest rate are the external factors considered. The findings reveal that leverage, return on assets, and firm age are the essential internal determinants that impact the liquidity of Indian listed firms. Furthermore, among the internal determinants, the results indicate that firm size, leverage ratio, return on assets ratio, and firm age are found to have a significant positive association with firms' LQD, except leverage ratio and firm age has a negative relationship with firms' LQD. From this result, this article has provides helpful ideas and empirical evidence on the inner and external determinants of the companies mentioned in India is very useful to bankers, analysts, regulators, investors and other stakeholders.

이중고리 합성에 블록제로서 이용된 피란과 피리딘

El-Hashash, Maher.A.,El-Sawy, Abdallah.A.,Eissa, Abdelmonem.M.F. 대한화학회 2009 대한화학회지 Vol.53 No.3

현재 수행하는 작업은 피페리딘 또는 암모늄 아세테이트 존재하에서 malononitrile와 $\beta$- aroylacrylic acid 유도체의 DMF 용매조건에서 상호작용에 대한 연구이며, 형성된 화합물을 이용한 퓨즈 되고 단리된 이중고리화 시스템의 합성에 관한 것이다. $\beta$-aroylacrylic acid (3)이 DMF 용매와 피페리딘 촉매조건에malononitrile와 반응하여 4H-피란유도체(4)를 형성한다. 촉매를 암모늄아세테이트로 바꿈으로서 피리딘 유도체를 얻었다. 또한 N-말레암산 유도체 (19)와 (27)은 말레 무수물과 함께 (4)와 (5)의 반응을 경유하여 합성되었다. 마이클 첨가 반응에서 이용되는 메틸렌화합물에 관한 이 연구는 B-aroylacrylic acid의 경우와 유사하게 형성된 말레암산 유도체의 반응성에 대한 것이다. The present work is devoted to study the interaction of $\beta$-aroylacrylic acid derivative (3) with malononitrile in (DMF) in the presence of piperidine and/or ammonium acetate, then using the formed compounds as starting materials for synthesizing fused and isolated heterocyclic systems. It has been established that the $\beta$-aroylacrylic acid (3) reacts with malononitrile in (DMF) in the presence of piperidine as a catalyst with the formation of 4H-pyran derivative (4). By changing the catalyst into ammonium acetate, pyridine derivative (5) has been obtained. Also the N-maleamic acid derivatives (19) and (27) have been synthesized via the interaction of (4) and (5) with maleic anhydride. The purpose of this step is to study the behavior of the formed maleamic acid derivatives – as analogies of $\beta$-aroylacrylic acids – towards different active methylene compounds under Michael addition reaction.