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- 저자 : M. J. Shim (검색결과 852 건)
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Park, J.K.,Lee, D.H.,Cho, C.H.,Yuk, S.S.,To, E.O.,Kwon, J.H.,Noh, J.Y.,Kim, B.Y.,Choi, S.W.,Shim, B.S.,Song, M.K.,Lee, J.B.,Park, S.Y.,Choi, I.S.,Song, C.S. Elsevier Scientific Pub. Co 2014 Veterinary microbiology Vol.169 No.3
Avian influenza virus (AIV) subtype H9N2 has been evolving rapidly and vaccine escape variants have been reported to cause circulation of infections and economic losses. In the present study, we developed and evaluated ectodomain of the AIV matrix 2 (M2e) protein as a supplementing antigen for oil-based inactivated H9N2 vaccine to increase resistance against vaccine escape variants. AIV H9N2 M2e antigen was expressed in Escherichia coli and supplemented to inactivated H9N2 oil emulsion vaccine. Specific pathogen-free chickens received a single injection of inactivated H9N2 oil emulsion vaccines with or without M2e supplementation. At three weeks post vaccination, hemagglutination inhibition tests and enzyme-linked immunosorbent assays were performed to determine serological immune responses. Challenge study using a vaccine escape H9N2 variant was performed to evaluate the efficacy of M2e supplementation. M2e antigen supplemented in oil emulsion vaccine was highly immunogenic, and a single M2e-supplemented vaccination reduced challenge virus replication and shedding more effectively than non-supplemented vaccination.
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Shim, Y.,Song, J.M. Academic Press 2015 Molecular and cellular probes Vol.29 No.6
Breast cancer is the major cause of cancer death for women worldwide. Breast cancer patients are treated with chemotherapy and radiotherapy. Although chemotherapy and radiotherapy are applied, some cancer cells still survive. These cells, called cancer stem cell (CSC), exhibit special capabilities, such as drug and radio resistance. The remaining CSC can trigger cancer recurrence. Thus, it is critical to find an effective way to target CSC. Capsaicin has been reported to affect anticancer activity in many cancers. It also has been shown that capsaicin induces apoptosis in the MCF-7 breast cancer cell line. In this study, we demonstrate that capsaicin causes dose-dependent growth disruption in breast CSC and inhibits translocation of notch intracellular membrane domain (NICD) into the nucleus. MCF-7 cells were treated with capsaicin at various concentrations (5 μM, 10 μM, and 20 μM) for 24 h. After capsaicin treatment, it was found that the number of breast CSC (%) decreased as the treatment concentration of capsaicin increased. This result was also confirmed with FACS. NICD translocation to the nucleus and apoptotic cell death of breast CSC were concurrently observed at the single breast CSC level using highly sensitive quantum dot (Qdot)-antibody nanoprobes. The control breast CSCs without the capsaicin treatment were able to translocate NICD into the nucleus. On the other hand, translocation of NICD into the nucleus was not observed in capsaicin-treated cells. In addition, apoptotic cell death was caused when the breast CSC were treated with capsaicin at more than 10 μM. Although many studies have shown that capsaicin produces anticancer activity in cancer cell lines, the present result is the first report to demonstrate that capsaicin is capable of causing breast CSC apoptotic cell death via inhibiting its notch signaling pathway.
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Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors
Shim, M.,Bae, J.Y.,Lee, Y.J.,Ahn, M.J. G. Fischer 2014 Phytomedicine Vol.21 No.5
<P>Aim: The stem bark of Maackia amurensis has been used as folk medicine for the treatment of cancer, cholecystitis, arthritis, and hyperthyroidism in females. In this study we examined the effects of the ethyl acetate fraction obtained from the 70% ethanol extract of M. amurensis and tectoridin, an active constituent isolated from the ethyl acetate fraction on thyroid and estrogen hormone activity. Methods: The effect of the ethanolic extract of M. amurensis stem bark on thyroid hormone activity was evaluated using thyroid hormone responsive-luciferase assay. We isolated tectoridin from the ethyl acetate fraction using a recrystallization method. T-screen assays were used to confirm thyroid hormone activity. The estrogenic activity of the ethyl acetate fraction of M. amurensis and tectoridin was evaluated by estrogen responsive-luciferase assay and estrogen receptor alpha regulation as compared to 17 beta-estradiol. Results: Both the ethyl acetate fraction and tectoridin activated thyroid-responsive reporters and increased thyroid hormone-dependent proliferation of rat pituitary GH3 cells, indicating modulation of thyroid hormone receptors. In parallel, the estrogenic activity of the fraction and tectoridin were characterized in a transient transfection system using estrogen-responsive luciferase plasmids in MCF-7 cells. The ethyl acetate fraction and tectoridin activated reporter gene expression and decreased the estrogen receptor protein level. Conclusions: These data indicate that tectoridin acts as a weak phytoestrogen as well as a thyroid hormone like agent by activating both estrogen and thyroid hormone receptors. (c) 2013 Elsevier GmbH. All rights reserved.</P>
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Shim, J.H.,Park, M.,Lee, Y.H.,Kim, S.,Im, Y.H.,Suh, J.Y.,Cho, Y.W. Pergamon Press ; Elsevier Science Ltd 2014 International journal of hydrogen energy Vol.39 No.1
Expanded natural graphite (ENG) was added to enhance the effective thermal conductivity of MgH<SUB>2</SUB>, which is one of the important parameters in the design of MgH<SUB>2</SUB>-based hydrogen storage tanks. Cylindrical MgH<SUB>2</SUB> compacts containing up to 20 wt% ENG flakes with various average sizes (20, 50, 200, 350 and 1200 μm) were fabricated to measure the effective thermal conductivity of MgH<SUB>2</SUB>-ENG mixtures. The radial direction effective thermal conductivity of the compacts was measured under a hydrogen atmosphere up to 70 bar. The conductivity was significantly enhanced by the addition of ENG flakes, reaching 9.3 W m<SUP>-1</SUP> K<SUP>-1</SUP> at 20 wt% ENG at 1 bar of hydrogen. It was observed that hydrogen pressure and the size of ENG flakes influenced the conductivity together with the amount of ENG. As hydrogen pressure increased up to 20 bar, the conductivity continued to increase. On the other hand, the conductivity very slowly increased above 20 bar, exhibiting a saturation tendency. It relatively rapidly increased with increasing average flake size up to 200 μm and then gradually decreased with further increasing size up to 1200 μm, exhibiting the maximum value at an average flake size of 200 μm. This trend might be determined by the competition between the thermal resistance at ENG/MgH<SUB>2</SUB> interfaces and the formation of conductive networks of ENG flakes.
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Triplet state and phosphorescence of hole-transport layer and its triplet exciton confinement
Seo, J.H.,Han, N.S.,Shim, H.S.,Park, S.M.,Kwon, J.H.,Song, J.K. North Holland ; Elsevier Science Ltd 2010 Chemical physics letters Vol.499 No.4
The triplet state of 4,4',4''-tris(3-methylphenylphenylamino)triphenylamine (m-MTDATA) and the dynamics of the singlet and the triplet states were examined to understand the confinement effect of m-MTDATA as host materials for phosphorescent organic light-emitting diodes. The time-resolved photoluminescence spectra revealed phosphorescence at approximately 480nm (2.58eV). The time constant of the T<SUB>1</SUB> state was 1.2μs. The dynamics of delayed fluorescence was closely related to that of phosphorescence. The triplet energy of a green phosphorescent sensitizer was well-confined in the m-MTDATA host, which suggests the application of m-MTDATA as possible host materials.
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Uniform and stable hydrogel-filled liposome-analogous vesicles with a thin elastomer shell layer
Seo, M.,Byun, A.,Shim, J.,Choi, H.S.,Lee, Y.,Kim, J.W. Elsevier 2016 Colloids and surfaces. B, Biointerfaces Vol.146 No.-
<P>This study introduces a new type of uniform liposome-analogous vesicle with a highly stable shell structure in which water-in-oil-in-water double emulsion drops fabricated in a capillary-based microfluidic device are used as templates. The vesicles developed in this work consist of a poly(ethylene glycol) hydro gel core surrounded by a polyurethane (PU) film between 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) layers. Subjecting the double emulsion templates to UV irradiation leads to the formation of a PU elastomer film between the DPPC layers. The presence of a thin PU film sandwiched between the DPPC layers is confirmed by confocal laser microscopy. The thicknesses of the PU films are measured to be approximately similar to 4 mu m. Further study reveals the incorporation of the PU film between the DPPC layers remarkably improves the shell impermeability. Our vesicle system is expected to be useful for regulating the permeation of small molecules through lipid -based vesicular films. (C) 2016 Elsevier B.V. All rights reserved.</P>
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간호대학생의 에니어그램 성격유형에 따른스트레스 대처방식
김희주,박가영,박지영,송예빈,심지현,이수연,이지영,장주희,정영민 이화여자대학교 간호과학대학 2011 이화간호학회지 Vol.- No.45
The purpose of this study is to analyze the relationship between stress coping behaviors and Enneagram personality types. The subject of the study is 342 college students who are attending 4-year nursing colleges in Seoul, Korea, and 198 students among them are qualified for the study. Typified statistical tools SPSS, chi-square, and ANOVA are used as analyzing methods in the study. The research results are as follows: 1. In nursing students, freshman class is the highest population in the study with 63 students(31.82 %), and the highest percentage of population does not have a religion(89 students, 44.95 %). 120 students (60.61 %) answered that their interpersonal relationships are good, and 105 students(53.03 %) are satisfied with the nursing major. 2. In Enneagram personality type, 9 type is the highest(42.42 %). 3. Problem focused coping type is the highest in stress coping behaviors(28.12(±20.16) points). 4. Problem focused coping behavior and social support coping behavior show significance. 5. Social support coping behavior shows significance, and 3 type scored the highest(17.67(±2.66) points). Further studies are suggested based on above results: First, in order to achieve more accurate results, the research of Enneagram and stress coping behavior with representative for sample Korean nursing students is necessary. Second, Development and verification the effect of stress coping program based on Enneagram personality types among nursing students are necessary.
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Synthesis of triarylamine-based alternating copolymers for polymeric solar cell
Lee, J.,Cha, H.,Kong, H.,Seo, M.,Heo, J.,Jung, I.H.,Kim, J.,Shim, H.K.,Park, C.E.,Kim, S.Y. IPC Science and Technology Press 2014 Polymer Vol.55 No.19
Two donor-acceptor alternating copolymers based on electron-rich triarylamine, di(1-(6-(2-ethylhexyl))naphthyl)phenylamine (DNPA), and electron-deficient benzothiadiazole and benzoselenadiazole derivatives were designed and synthesized via Suzuki coupling reaction. The resulting triarylamine-based alternating copolymers PDNPADTBT and PDNPADTBS showed good solubility in common organic solvents and good thermal stability. The optical band gaps determined from the onset absorption were 1.93 and 1.81 eV, respectively. By introducing the naphthalene ring into the triarylamine, copolymers had relatively deep HOMO energy levels of -5.48 and -5.45 eV, which led to a high open circuit voltage (V<SUB>oc</SUB>) and good air stability for photovoltaic application. Bulk heterojunction solar cells were fabricated with a structure of ITO/PEDOT-PSS/copolymers-PC<SUB>70</SUB>BM/LiF/Al by blending the copolymer with PC<SUB>70</SUB>BM. Both blend systems showed remarkably high V<SUB>oc</SUB> near 0.9 V, and the highest performance of 2.2% was obtained from PDNPADTBT, with V<SUB>oc</SUB> = 0.88 V, J<SUB>sc</SUB> = 7.4 mA/cm<SUP>2</SUP>, and a fill factor of 34.4% under AM 1.5 G.
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