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      • KCI등재

        Synergistic Effect of Fly Ash and Bentonite as Partial Replacement of Cement in Mass Concrete

        M. E. Shabab,K. Shahzada,B. Gencturk,M. Ashraf,M. Fahad 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.5

        This research focuses on the effects of using fly ash and bentonite as partial replacement of ordinary Portland cement (OPC) in mass concrete. Replacement of OPC with supplementary cementing materials such as fly ash or bentonite is one of the promising ways to mitigate thermal cracking due to temperature differentials in mass concrete. In this study, three types of concrete mixes with varying amount of partial replacement of OPC were investigated, 25% bentonite, 25% fly ash, and 12.5% bentonite and 12.5% fly ash. These mixtures were named BM, FM and BF, respectively. A fourth control mixture (CM) with no OPC replacement was also studied for comparison purposes. From each mix, one large specimen (having 600 × 800 × 1000 mm overall dimensions) representing mass concrete, and concrete cylinders of standard size representing normal structural concrete were prepared. Various tests were performed on these specimens at ages of 7, 14, 28, 56 and 91 days. Comparatively, BF was the most effective in controlling temperature rise in mass concrete. Moreover, this mix resulted in the highest values of compressive strength at 91 days and higher early-age strength. Ultrasonic pulse velocity (UPV) tests were conducted on mass concrete samples as well as on cores extracted from concrete blocks. Results of these tests revealed that mass concrete blocks made of BF and FM resulted in more uniform properties, or in other words, suffered least from large concrete placement by reducing the heat of hydration.

      • KCI등재

        Fire performance curves for unprotected HSS steel column

        M. Shahria Alam,A.H.M. Muntasir Billah,Shahriar Quayyum,Mahmud Ashraf,A.N.M. Rafi,Ahmad Rteil 국제구조공학회 2013 Steel and Composite Structures, An International J Vol.15 No.6

        The behaviour of steel column at elevated temperature is significantly different than that atambient temperature due to its changes in the mechanical properties with temperature. Reported literaturesuggests that steel column may become vulnerable when exposed to fire condition, since its strength andcapacity decrease rapidly with temperature. The present study aims at investigating the lateral load resistanceof non-insulated steel columns under fire exposure through finite element analysis. The studied parametersinclude moment-rotation behaviour, lateral load-deflection behaviour, stiffness and ductility of columns atdifferent axial load levels. It was observed that when the temperature of the column was increased, there wasa significant reduction in the lateral load and moment capacity of the non-insulated steel columns. Moreover,it was noted that the stiffness and ductility of steel columns decreased sharply with the increase intemperature, especially for temperatures above 400°C. In addition, the lateral load capacity and the momentcapacity of columns were plotted against fire exposure time, which revealed that in fire conditions, thenon-insulated steel columns experience substantial reduction in lateral load resistance within 15 minutes offire exposure.

      • Physicochemical analysis of structural alteration and advanced glycation end products generation during glycation of H2A histone by 3-deoxyglucosone : GLYCATING POTENTIAL OF 3-DG WITH H2A HISTONE PROTEIN

        Ashraf, Jalaluddin M.,Ahmad, Saheem,Rabbani, Gulam,Jan, Arif Tasleem,Lee, Eun Ju,Khan, Rizwan Hasan,Choi, Inho Wiley (John WileySons) 2014 IUBMB life Vol.66 No.10

        <P>Advanced glycation end-products comprise a complex and heterogeneous group of compounds that have been implicated in diabetes-related complications. The importance of the Maillard reaction is depicted by the formation of reactive intermediate products known as α-oxoaldehydes, such as 3-deoxyglucosone (3-DG). This product has been found to be involved in accelerated vascular damage in diabetes. In the present study, calf thymus histone H2A was reacted with 3-DG, and the generation of advanced glycation end products was investigated by determining the degree of side chain modifications (lysine and arginine residues), Amadori products, carbonyl content, N(ε) -carboxymethyl lysine, and pentosidine using various physicochemical techniques. Moreover, fluorescence, absorbance as well as structural characteristics of glycated-H2A were comprehensively investigated. Overall, this study demonstrates structural perturbation, formation of different intermediates, and AGEs that are believed to hamper the normal functioning of H2A histone, compromising the integrity of chromatin structures and function in secondary complications of diabetes.</P>

      • KCI등재

        Anticancer activities of some newly synthesized pyrazole and pyrimidine derivatives

        Ashraf M. Mohamed,Weal A. El-Sayed,Musaed A. Alsharari,Husam R. M. Al-Qalawi,Mousa O. Germoush 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.9

        A series of pyrazolopyridine and pyridopyrimidinederivatives 2–6 were newly synthesized using3,5-bisarylmethylene-1-methylpiperidone as the startingmaterial. The anticancer activities of the synthesizedcompounds were evaluated using 59 different human tumorcell lines, representing cancers of CNS, ovary, renal,breast, colon, lung, leukemia, and melanoma, prostate aswell as kidney. Some of the tested compounds, especiallythose with a fluorine substituent at the para-position in thephenyl ring and those with a pyridopyrimidine-2-thionewith a free –NH or –SH, exhibited greater in vitro antitumoractivities at low concentrations (log 10 [GI50] =-4.6) against the human tumor cell lines. Additionally,some of the compounds had moderate inhibitory effects onthe growth of the cancer cell lines. The detailed synthesis,spectroscopic data and antitumor properties of the synthesizedcompounds are reported.

      • SCIESCOPUSKCI등재

        A Study of Some Economic Traits of Indigenous Cattle and their Crossbreeds in Southern Bangladesh

        Ashraf, A.,Islam, S.S.,Islam, A.B.M.M.,Ali, S.Z. Asian Australasian Association of Animal Productio 2000 Animal Bioscience Vol.13 No.9

        The experiment was conducted on 69 cows to identify the quantitative variations of some economic traits of five genetic groups as $Local{\times}Friesian $ $F_1$, $Local{\times}Sahiwal$ $F_1$, Local (indigenous zebu type), $Local{\times}Sindhi $ $F_1$, and $Local{\times}Hariana$ $F_1$. The traits studied were age at weaning, age at first heat, age at first conception, services per conception, daily milk yield, lactation length, lactation yield and post partum heat period. The records on milking and reproduction performances of cows and heifers were obtained from farm register and by interviewing the farmers. It was observed that the lowest age at weaning, age at first heat and age at first conception were $5.37{\pm}0.24$, $27.17{\pm}1.72$ and $27.83{\pm}1.82$ months respectively in $Local{\times}Hariana$ $F_1$. Services per conception were lowest in $Local{\times}Sahiwal$ $F_1$ $(1.08{\pm}0.18)$ although not significantly (p>0.05) affected by farms, genetic groups and $farm{\times}genetic$ groups interaction. Average daily milk yield was highest in $Local{\times}Friesian$ $F_1$ $(5.81 {\pm}0.40 kg)$. Lactation length and lactation yield were highest in $Local{\times}Sahiwal$ $F_1$ ($299.38{\times}9.74$ days and $1863.00{\pm}141.00kg $ respectively). Average post partum heat period was lowest in $Local{\times}Sindhi$ $F_1$ ($3.19{\pm}0.38$ months). Least squares ANOVA showed that farm had significant (p<0.001) effect on age at weaning, age at first heat, age at first conception and post partum heat period. There was insignificant (p>0.05) effect of farm on services per conception, daily milk yield, lactation length and lactation yield, whereas genetic groups had a significant effect for all the traits under review except services per conception. $Farm{\times}genetic$ groups interaction was insignificant for all of the traits under consideration except age at weaning.

      • KCI등재

        Characterization of the Heavy Metals Contaminating the River Nile at El-Giza Governorate, Egypt and Their Relative Bioaccumulations in Tilapia nilotica

        Ashraf M. Morgan,Ho-Chul Shin,A.M. Abd El Aty 한국독성학회 2008 Toxicological Research Vol.24 No.4

        This study was carried out to measure the concentration of heavy metals (Pb, Mn, Cr, Cd, Ni, Zn, and Cu) in water and Bolti fish (Tilapia nilotica) samples collected from Rasheed branch of River Nile, north of El-Giza Governorate, Egypt by atomic absorption spectrophotometry. The investigated districts through which the branch passes include El-Manashi, Gezzaya, El Katta, Abo Ghaleb and Wardan. Based on WHO and FAO safety reference standards, the results of the current study showed that water and fish tissues were found to contain heavy metals at significantly variable concentration levels among the investigated districts. They were polluted with respect to all the metals tested at Gezzaya district. However, the levels of analyzed metals in water and fish tissues were found lower than legal limits in other districts. The heavy metals showed differential bioaccumulation in fish tissues of the different districts as the accumulation pattern (as total heavy metal residues) was district dependant as follow: Gezzaya >Wardan > El Katta > Abo Ghaleb > El Manashi.

      • KCI등재

        Lignocellulosic Sugar Palm Fibre-Reinforced Thermoplastic Composites: Mechanical, Thermal and Dynamic Mechanical Properties

        M. R. M. Asyraf,K. Z. Hazrati,Desmond Daniel Chin Vui Sheng,M. Rafdah,W. Ashraf,Emrah Madenci,Yasin Onuralp Özkılıç,Ceyhun Aksoylu,N. M. Nurazzi 한국섬유공학회 2023 Fibers and polymers Vol.24 No.8

        Lignocellulosic fibre obtained from forest biomass has various advantages, especially in product development due to its abundance and ability in mechanical properties. Sugar palm fibre (SPF) has emerged as promising fibre reinforcement in composite industries to form high-strength and stiffness biocomposites. Due to environmental concerns such as air pollution and global warming, the global community has worked together to replace conventional plastic with biomass waste like SPF in various product types. Traditionally, sugar palm by-products are useful for various traditional uses such as traditional foods, gula kabung, and alcohol, while SPF is applied as rope, brooms and brushes. Numerous researchers have taken initiatives to implement SPF in the packaging sector and transport uses such as lifeguard boats. Some works have proved that SPF-reinforced polymer composites exhibit high mechanical strength and remarkable properties in thermal degradations. However, like other lignocellulosic fibres, the SPF exhibits high water absorption properties, which causes problems binding with thermoplastic matrix, reducing its performance. Based on the literature survey, no review has been carried out on discussing the mechanical and thermal behaviour of SPF-reinforced thermoplastic composites. Hence, the current review aims to establish concise and collective findings from previous works on SPF/thermoplastic composites to provide a good source of literature for further research on this topic.

      • Antiglycating potential of gum arabic capped-silver nanoparticles.

        Ashraf, Jalaluddin M,Ansari, Mohammad Azam,Choi, Inho,Khan, Haris M,Alzohairy, Mohammad A Humana Press 2014 Applied biochemistry and biotechnology Vol.174 No.1

        <P>Advanced glycation end products are major contributors to the pathology of diabetes, Alzheimer's disease, and atherosclerosis; accordingly, identification of antiglycation compounds is attracting considerable interest. In the present study, the inhibitory effect of gum arabic capped-silver nanoparticles on advanced glycation end products formation was monitored by several biophysical techniques. Silver nanoparticles were characterized by ultraviolet-visible, high-resolution transmission electron microscopy, and energy-dispersive X-ray spectroscopy. Bovine serum albumin and methylglyoxal mixtures incubated with increasing concentrations of silver nanoparticles showed significant reductions in advanced glycation end product formation that were confirmed by ultraviolet-visible, fluorescence spectrometry, and high-performance liquid chromatography techniques. High-performance liquid chromatography showed decreased adduct formation of glycated protein in the presence of silver nanoparticles. The structural changes induced by silver nanoparticles were further confirmed by circular dichroism and Fourier transform infrared spectroscopy. Strong inhibition of advanced glycation end product formation was observed in the presence of elevated silver nanoparticles. The results of this study suggest that silver nanoparticles are a potent antiglycating agent.</P>

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