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RISS 인기검색어
- 검색키워드
- 저자 : Luyang Zhao (검색결과 6 건)
- 무료
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Flyback AC-DC Converter with Low THD Based on Primary-Side Control
Changyuan Chang,Luyang He,Zixuan Cao,Dadi Zhao 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.6
A single-stage flyback LED AC-DC converter based on primary-side control under constant current mode is proposed in this study. The proposed converter features low total harmonic distortion (THD) and high power factor (PF). It also consists of a zero-crossing distortion compensation circuit and a variable duty ratio control compensation circuit to deal with the line current distortions caused by fixed duty ratio control. The system model and layout are built in Simplis and Cadence, respectively. The feasibility and performance of the proposed circuit is verified by designing and fabricating an IC controller in the HHNEC 0.35 μm 5 V/40 V HVCMOS process. Experimental results show that the PF can reach a level in the range of 0.985–0.9965. Moreover, the average THD of the entire system is approximately 10%, with the minimum being 6.305%, as the input line voltage changes from 85 VAC to 265 VAC.
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Rapid Dynamic Response Flyback AC-DC Converter Design
Changyuan Chang,Menglin Wu,Luyang He,Dadi Zhao 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.6
A constant voltage AC-DC converter based on digital assistant technology is proposed in this paper, which has rapid dynamic response capability. The converter operates in the PFM (Pulse Frequency Modulation) mode. According to the load state, the compensation current produced by the digital compensation module was injected into the CS pin to adjust the switching pulse width dynamically and improve the dynamic response. The control chip is implemented based on NEC 1μm 5V/40V HVCMOS process. A 5V/1.2A prototype has been built to verify the proposed control method. When the load jumps from idle to heavy, the undershoot time is only 7.4ms.
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Flyback AC-DC Converter with Low THD Based on Primary-Side Control
Chang, Changyuan,He, Luyang,Cao, Zixuan,Zhao, Dadi The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.6
A single-stage flyback LED AC-DC converter based on primary-side control under constant current mode is proposed in this study. The proposed converter features low total harmonic distortion (THD) and high power factor (PF). It also consists of a zero-crossing distortion compensation circuit and a variable duty ratio control compensation circuit to deal with the line current distortions caused by fixed duty ratio control. The system model and layout are built in Simplis and Cadence, respectively. The feasibility and performance of the proposed circuit is verified by designing and fabricating an IC controller in the HHNEC $0.35{\mu}m$ 5 V/40 V HVCMOS process. Experimental results show that the PF can reach a level in the range of 0.985-0.9965. Moreover, the average THD of the entire system is approximately 10%, with the minimum being 6.305%, as the input line voltage changes from 85 VAC to 265 VAC.
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Rapid Dynamic Response Flyback AC-DC Converter Design
Chang, Changyuan,Wu, Menglin,He, Luyang,Zhao, Dadi The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.6
A constant voltage AC-DC converter based on digital assistant technology is proposed in this paper, which has rapid dynamic response capability. The converter operates in the PFM (Pulse Frequency Modulation) mode. According to the load state, the compensation current produced by the digital compensation module was injected into the CS pin to adjust the switching pulse width dynamically and improve the dynamic response. The control chip is implemented based on NEC $1{\mu}m$ 5V/40V HVCMOS process. A 5V/1.2A prototype has been built to verify the proposed control method. When the load jumps from idle to heavy, the undershoot time is only 7.4ms.
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Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy
Qingbin He,Runxiao Zheng,Junchi Ma,Luyang Zhao,Yafang Shi,Jianfeng Qiu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background The activation of the cyclic guanosine monophosphate-adenosine monophosphate synthasestimulator of interferon genes (cGAS-STING) signaling pathway has attracted great attention for its ability to up-regulate innate immune response and thus enhance cancer immunotherapy. However, many STING agonists limit the further advancement of immunotherapy due to weak tumor responsiveness or low activation efficiency. The responsive and effective activation of cGAS-STING signaling in tumors is a highly challenging process. Methods In this study, a manganese-based nanoplatform (MPCZ NPs) was constructed that could responsively and efficiently generate more manganese ions (Mn2+) and reactive oxygen species (ROS) to activate cGAS-STING signaling pathway. Briefly, manganese dioxide (MnO2) was loaded with zinc protoporphyrin IX (ZPP) molecule and coated by polydopamine (PDA) embedded with NH4HCO3 to obtain MPCZ NPs. Additionally, MPCZ NPs were evaluated in vitro and in vivo for their antitumor effects by methyl thiazolyl tetrazolium (MTT) assay and TUNEL assays, respectively. Results In this system, tumor responsiveness was achieved by exogenous (laser irradiation) and endogenous (high levels GSH) stimulation, which triggered the collapse or degradation of PDA and MnO2. Moreover, the release of Mn2+ augmented the cGAS-STING signaling pathway and enhanced the conversion of hydrogen peroxide (H2O2) to hydroxyl radical (·OH) under NIR laser irradiation. Furthermore, the release of ZPP and the elimination of GSH by MPCZ NPs inhibited HO-1 activity and prevented ROS consumption, respectively. Conclusions This adopted open source and reduce expenditure strategy to effectively generate more ROS and Mn2+ to responsively activate cGAS-STING signaling pathway, providing a new strategy for improving immunotherapy.
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Lu Yang,Xiaoxiang Chen,Zirong Bi,Jun Liao,Weian Zhao,Wenqi Huang 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.5
Apoptosis is proved responsible for renal damage during ischemia/reperfusion. The regulation for renal apoptosis induced by ischemia/reperfusion injury (IRI) has still been unclearly characterized to date. In the present study, we investigated the regulation of histone acetylation on IRI-induced renal apoptosis and the molecular mechanisms in rats with the application of curcumin possessing a variety of biological activities involving inhibition of apoptosis. Sprague–Dawley rats were randomized into four experimental groups (SHAM, IRI, curcumin, SP600125). Results showed that curcumin significantly decreased renal apoptosis and caspase-3/-9 expression and enhanced renal function in IRI rats. Treatment with curcumin in IRI rats also led to the decrease in expression of p300/cyclic AMP response element-binding protein (CBP) and activity of histone acetyltransferases (HATs). Reduced histone H3 lysine 9 (H3K9) acetylation was found near the promoter region of caspase-3/-9 after curcumin treatment. In a similar way, SP600125, an inhibitor of c-Jun N-terminal kinase (JNK), also attenuated renal apoptosis and enhanced renal function in IRI rats. In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125. These results indicate that curcumin could attenuate renal IRI via JNK/p300/CBP-mediated anti-apoptosis signaling.
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