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RISS 인기검색어
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- 저자 : Junchi Ma (검색결과 4 건)
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Wang, Yuli,Ma, Junchi,Du, Yifei,Miao, Jing,Chen, Ning Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.3
Epidemiological evidence suggests that bone is especially sensitive to oxidative stress, causing bone loss in the elderly. Previous studies indicated that human amnion-derived mesenchymal stem cells (HAMSCs), obtained from human amniotic membranes, exerted osteoprotective effects in vivo. However, the potential of HAMSCs as seed cells against oxidative stress-mediated dysfunction is unknown. In this study, we systemically investigated their antioxidative and osteogenic effects in vitro. Here, we demonstrated that HAMSCs significantly promoted the proliferation and osteoblastic differentiation of $H_2O_2$-induced human bone marrow mesenchymal stem cells (HBMSCs), and down-regulated the reactive oxygen species (ROS) level. Further, our results suggest that activation of the ERK1/2 MAPK signal transduction pathway is essential for both HAMSCs-mediated osteogenic and protective effects against oxidative stress-induced dysfunction in HBMSCs. U0126, a highly selective inhibitor of extracellular ERK1/2 MAPK signaling, significantly suppressed the antioxidative and osteogenic effects in HAMSCs. In conclusion, by modulating HBMSCs, HAMSCs show a strong potential in treating oxidative stress- mediated bone deficiency.
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Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy
Qingbin He,Runxiao Zheng,Junchi Ma,Luyang Zhao,Yafang Shi,Jianfeng Qiu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background The activation of the cyclic guanosine monophosphate-adenosine monophosphate synthasestimulator of interferon genes (cGAS-STING) signaling pathway has attracted great attention for its ability to up-regulate innate immune response and thus enhance cancer immunotherapy. However, many STING agonists limit the further advancement of immunotherapy due to weak tumor responsiveness or low activation efficiency. The responsive and effective activation of cGAS-STING signaling in tumors is a highly challenging process. Methods In this study, a manganese-based nanoplatform (MPCZ NPs) was constructed that could responsively and efficiently generate more manganese ions (Mn2+) and reactive oxygen species (ROS) to activate cGAS-STING signaling pathway. Briefly, manganese dioxide (MnO2) was loaded with zinc protoporphyrin IX (ZPP) molecule and coated by polydopamine (PDA) embedded with NH4HCO3 to obtain MPCZ NPs. Additionally, MPCZ NPs were evaluated in vitro and in vivo for their antitumor effects by methyl thiazolyl tetrazolium (MTT) assay and TUNEL assays, respectively. Results In this system, tumor responsiveness was achieved by exogenous (laser irradiation) and endogenous (high levels GSH) stimulation, which triggered the collapse or degradation of PDA and MnO2. Moreover, the release of Mn2+ augmented the cGAS-STING signaling pathway and enhanced the conversion of hydrogen peroxide (H2O2) to hydroxyl radical (·OH) under NIR laser irradiation. Furthermore, the release of ZPP and the elimination of GSH by MPCZ NPs inhibited HO-1 activity and prevented ROS consumption, respectively. Conclusions This adopted open source and reduce expenditure strategy to effectively generate more ROS and Mn2+ to responsively activate cGAS-STING signaling pathway, providing a new strategy for improving immunotherapy.
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Ning Chen,Yuli Wang,Junchi Ma,Yifei Du,Jing Miao 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.3
Epidemiological evidence suggests that bone is especial-ly sensitive to oxidative stress, causing bone loss in the elderly. Previous studies indicated that human amnion-derived mesenchymal stem cells (HAMSCs), obtained from human amniotic membranes, exerted osteoprotective effects in vivo. However, the potential of HAMSCs as seed cells against oxidative stress-mediated dysfunction is unknown. In this study, we systemically investigated their antioxidative and osteogenic effects in vitro. Here, we demonstrated that HAMSCs significantly promoted the proliferation and osteoblastic differentiation of H2O2-induced human bone marrow mesenchymal stem cells (HBMSCs), and down-regulated the reactive oxygen species (ROS) level. Further, our results suggest that activation of the ERK1/2 MAPK signal transduction pathway is essential for both HAMSCs-mediated osteogenic and protective effects against oxidative stress-induced dysfunction in HBMSCs. U0126, a highly selective inhibitor of extracellular ERK1/2 MAPK signaling, significantly suppressed the antioxidative and osteogenic effects in HAMSCs. In conclusion, by modulating HBMSCs, HAMSCs show a strong potential in treating oxidative stress- mediated bone deficiency.
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Zhang Ziyi,Ding Honglei,Zhou Qi,Pan Weiguo,Qiu Kaina,Mu Xiaotian,Ma Junchi,Zhang Kai,Zhao Yuetong 한국탄소학회 2023 Carbon Letters Vol.33 No.4
In recent years, people are increasingly interested in CO2 hydrogenation to produce value-added chemicals and fuels (CH4, CH3OH, etc.). In the quest for an efficient treatment in CO2 methanation and methanolization, several technologies have been practiced, and DBD plasma technology gain attention due to its easily handling, mild operating conditions, strong activation ability, and high product selectivity. In addition, its reaction mechanism and the effect of packing materials and reaction parameters are still controversial. To address these problems efficiently, a summary of the reaction mechanism is presented. A discussion on plasma-catalyzed CO2 hydrogenation including packing materials, reaction parameters, and optimizing methods is addressed. In this review, the overall status and recent findings in DBD plasma-catalyzed CO2 hydrogenation are presented, and the possible directions of future development are discussed.
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