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Lujan-Hernandez, Jorge,Appasani, Raghu,Sullivan, Kylee,Siegel-Reamer, Leah,Lalikos, Janice F. Korean Society of Plastic and Reconstructive Surge 2017 Archives of Plastic Surgery Vol.44 No.5
As the popularity of fat grafting research increases, animal models are being used as the source of pre-clinical experimental information for discovery and to enhance techniques. To date, animal models used in this research have not been compared to provide a standardized model. We analyzed publications from 1968-2015 to compare published accounts of animal models in fat grafting research. Data collected included: species used, graft characteristics (donor tissue, recipient area, amount injected, injection technique), time of sacrifice and quantification methods. Mice were most commonly used (56% of studies), with the "athymic nude" strain utilized most frequently (44%). Autologous fat was the most common source of grafted tissue (52%). Subcutaneous dorsum was the most common recipient site (51%). On average, $0.80{\pm}0.60mL$ of fat was grafted. A single bolus technique was used in 57% of studies. Fat volume assessment was typically completed at the end of the study, occurring at less than 1 week to one year. Graft volume was quantified by weight (63%), usually in conjunction with another analysis. The results demonstrate the current heterogeneity of animal models in this research. We propose that the research community reach a consensus to allow better comparison of techniques and results. One example is the model used in our laboratory and others; this model is described in detail. Eventually, larger animal models may better translate to the human condition but, given increased financial costs and animal facility capability, should be explored when data obtained from small animal studies is exhausted or inconclusive.
Jorge Lujan-Hernandez,Raghu Appasani,Kylee Sullivan,Leah Siegel-Reamer,Janice F Lalikos 대한성형외과학회 2017 Archives of Plastic Surgery Vol.44 No.5
As the popularity of fat grafting research increases, animal models are being used as the source of pre-clinical experimental information for discovery and to enhance techniques. To date, animal models used in this research have not been compared to provide a standardized model. We analyzed publications from 1968–2015 to compare published accounts of animal models in fat grafting research. Data collected included: species used, graft characteristics (donor tissue, recipient area, amount injected, injection technique), time of sacrifice and quantification methods. Mice were most commonly used (56% of studies), with the “athymic nude” strain utilized most frequently (44%). Autologous fat was the most common source of grafted tissue (52%). Subcutaneous dorsum was the most common recipient site (51%). On average, 0.80±0.60 mL of fat was grafted. A single bolus technique was used in 57% of studies. Fat volume assessment was typically completed at the end of the study, occurring at less than 1 week to one year. Graft volume was quantified by weight (63%), usually in conjunction with another analysis. The results demonstrate the current heterogeneity of animal models in this research. We propose that the research community reach a consensus to allow better comparison of techniques and results. One example is the model used in our laboratory and others; this model is described in detail. Eventually, larger animal models may better translate to the human condition but, given increased financial costs and animal facility capability, should be explored when data obtained from small animal studies is exhausted or inconclusive.
Alberto Broatch,Manuel Lujan,Santiago Ruiz,Pablo Olmeda 한국자동차공학회 2008 International journal of automotive technology Vol.9 No.2
Most of hydrocarbon (HC) and carbon monoxide (CO) emissions from automotive DI Diesel engines are produced during the engine warm-up period and are primarily caused by difficulties in obtaining stable and efficient combustion under these conditions. Furthermore, the contribution of engine starting to these emissions is not negligible; since this operating condition is highly unfavorable for the combustion progress. Additionally, the catalytic converter is ineffective due to the low engine temperature. In conjunction with adequate engine settings (fuel injection and fresh air control), either the glow plugs or the intake air heater are activated during a portion of the engine warm-up period, so that a nominal engine temperatures is reached faster, and the impact of these difficulties is minimized. Measurement of gaseous pollutants during engine warm-up is currently possible with detectors used in standard exhaust gas analyzers (EGA), which have response times well-suited for sampling at such transient conditions. However, these devices are not suitable for the measurement of exhaust emissions produced during extremely short time intervals, such as engine starting. Herein, we present a methodology for the measurement of the cumulative pollutant emissions during the starting phase of passenger car DI Diesel engines, with the goal of overcoming this limitation by taking advantage of standard detectors. In the proposed method, a warm canister is filled with an exhaust gas sample at constant volumetric flow, during a time period that depends on the engine starting time; the gas concentration in the canister is later evaluated with a standard EGA. When compared with direct pollutant measurements performed with a state-of-art EGA, the proposed procedure was found to be more sensitive to combustion changes and provided more reliable data.
Petrochemical effluent treatment using natural coagulants and an aerobic biofilter
Bandala, Erick R.,Tiro, Juan Bernardo,Lujan, Mariana,Camargo, Francisco J.,Sanchez-Salas, Jose Luis,Reyna, Silvia,Moeller, Gabriela,Torres, Luis G. Techno-Press 2013 Advances in environmental research Vol.2 No.3
Coagulation-flocculation (CF) was tested coupled with an aerobic biofilter to reduce total petroleum hydrocarbon (TPHs) concentration and toxicity from petrochemical wastewater. The efficiency of the process was followed using turbidity and chemical oxygen demand (COD). The biofilter was packed with a basaltic waste (tezontle) and inoculated with a bacterial consortium. Toxicity test were carried out using Lactuca sativa var. capitata seeds. Best results for turbidity removal were obtained using alum. Considerable turbidity removal was obtained when using Opuntia spp. COD removal with alum was 25%, for Opuntia powder it was 36%. The application of the biofilter allowed the removal of 70% of the remaining TPHs after 30 days with a biodegradation rate (BDR) value 47 $mgL^{-1}d^{-1}$. COD removal was slightly higher with BDR value 63 $mgL^{-1}d^{-1}$. TPH kinetics allowed a degradation rate constant equal to $4.05{\times}10^{-2}d^{-1}$. COD removal showed similar trend with $k=4.23{\times}10^{-2}d^{-1}$. Toxicity reduction was also successfully achieved by the combined treatment process.
Seungleal Brian Paek,Emily Jane Knight,Su-Youne Chang,J. Luis Lujan,장동표,Kevin E. Bennet,Kendall H. Lee 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.2
Purpose Deep Brain Stimulation (DBS) has been effective in treating various neurological and psychiatric disorders; however, its underlying mechanism hasn’t been completely understood. Fast scan cyclic voltammetry (FSCV) is a valuable tool to elucidate underlying neurotransmitter mechanisms of DBS, due to its sub-second temporal resolution and direct identification of analytes. However, since DBS-like high frequency stimulation evokes neurotransmitter release as well as extracellular pH shift, it is hard to isolate the neurotransmitter signal from the complex environment. Here we demonstrate the efficacy of a modified FSCV technique, Paired Pulse Voltammetry (PPV), in detecting dopamine (DA) release in the caudate nucleus during long-term electrical stimulation of the medial forebrain bundle (MFB) in the rat. Methods Unlike traditional FSCV applying a single triangular waveform, PPV employs a binary waveform with a specific time gap (2.2 ms) in between the comprising pulses. DA measurement was performed with a carbon fiber microelectrode placed in the caudate nucleus and a twisted bipolar stimulating electrode in the MFB. PPV data was collected with the Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS). Results Using PPV, the detection of DA was evident throughout the long-term stimulation (5 minutes); however, without PPV, in vivo environmental changes including pH shift eventually obscured the characteristic oxidation current of DA at 0.6V. Conclusions These results indicate that PPV can be a valuable tool to accurately determine DA dynamics in a complex in vivo environment during long-term electrical stimulation.
Kendall H. Lee,Seungleal Brian Paek,Emily Jane Knight,Su-Youne Chang,J. Luis Lujan,장동표,Kevin E. Bennet 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.1
Purpose Deep Brain Stimulation (DBS) has been effective in treating various neurological and psychiatric disorders;however, its underlying mechanism hasn’t been completely understood. Fast scan cyclic voltammetry (FSCV) is a valuable tool to elucidate underlying neurotransmitter mechanisms of DBS, due to its sub-second temporal resolution and direct identification of analytes. However, since DBS-like high frequency stimulation evokes neurotransmitter release as well as extracellular pH shift, it is hard to isolate the neurotransmitter signal from the complex environment. Here we demonstrate the efficacy of a modified FSCV technique, Paired Pulse Voltammetry (PPV), in detecting dopamine (DA) release in the caudate nucleus during long-term electrical stimulation of the medial forebrain bundle (MFB) in the rat. Methods Unlike traditional FSCV applying a single triangular waveform, PPV employs a binary waveform with a specific time gap (2.2 ms) in between the comprising pulses. DA measurement was performed with a carbon fiber microelectrode placed in the caudate nucleus and a twisted bipolar stimulating electrode in the MFB. PPV data was collected with the Wireless Instantaneous Neurochemical Concentration Sensing System (WINCS). Results Using PPV, the detection of DA was evident throughout the long-term stimulation (5 minutes); however, without PPV,in vivo environmental changes including pH shift eventually obscured the characteristic oxidation current of DA at 0.6V. Conclusions These results indicate that PPV can be a valuable tool to accurately determine DA dynamics in a complex in vivo environment during long-term electrical stimulation.
Printed Polymer and a-Si TFT Backplanes for Flexible Displays
Street, R.A.,Wong, W.S.,Ready, S.E.,Chabinyc, M.L.,Arias, A.C.,Daniel, J.H.,Apte, R.B.,Salleo, A.,Lujan, R.,Ong, Beng,Wu, Yiliang The Korean Infomation Display Society 2005 Journal of information display Vol.6 No.3
The need for low cost, flexible, thin film transistor (TFT) display backplanes has focused attention on new processing techniques and materials. We report the development of TFT backplane technology based entirely on jet-printing, using a combination of additive and subtractive processing, to print active materials or etch masks. The technique eliminates the use of photolithography and has the potential to reduce the array manufacturing cost. The printing technique is demonstrated with both amorphous silicon and polymer semiconductor TFT arrays, and we show results of small prototype displays.