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- 저자 : Liya Xie (검색결과 2 건)
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Lan Li,Peng Wang,Jing Jin,Chunmei Xie,Bin Xue,Jiancheng Lai,Liya Zhu,Qing Jiang 한국생체재료학회 2022 생체재료학회지 Vol.26 No.4
Background: The meniscus injury is a common disease in the area of sports medicine. The main treatment for this disease is the pain relief, rather than the meniscal function recovery. It may lead to a poor prognosis and accelerate the progression of osteoarthritis. In this study, we designed a meniscal scaffold to achieve the purposes of meniscal function recovery and cartilage protection. Methods: The meniscal scaffold was designed using the triply periodic minimal surface (TPMS) method. The scaffold was simulated as a three-dimensional (3D) intact knee model using a finite element analysis software to obtain the results of different mechanical tests. The mechanical properties were gained through the universal machine. Finally, an in vivo model was established to evaluate the effects of the TPMS-based meniscal scaffold on the cartilage protection. The radiography and histological examinations were performed to assess the cartilage and bony structures. Different regions of the regenerated meniscus were tested using the universal machine to assess the biomechanical functions. Results: The TPMS-based meniscal scaffold with a larger volume fraction and a longer functional periodicity demonstrated a better mechanical performance, and the load transmission and stress distribution were closer to the native biomechanical environment. The radiographic images and histological results of the TPMS group exhibited a better performance in terms of cartilage protection than the grid group. The regenerated meniscus in the TPMS group also had similar mechanical properties to the native meniscus. Conclusion: The TPMS method can affect the mechanical properties by adjusting the volume fraction and functional periodicity. The TPMS-based meniscal scaffold showed appropriate features for meniscal regeneration and cartilage protection.
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Shuifan Zhou,Zhenqing Hou,Yang Li,Fei Cui,Mengmeng Jia,Xiangrui Yang,Yange Wang,Liya Xie,Qiqing Zhang 한국고분자학회 2014 Macromolecular Research Vol.22 No.1
The efficacy of magnetic nanoparticles (MNPs) for biomedical applications depends on the specic targetingcapacity, blood circulation time and magnetic susceptibility. Functionalized chitosan-coated Fe3O4 nanoparticles(CS-coated Fe3O4 NPs) were synthesized by a non-solvent-aided coacervation procedure followed by a chemicalcrosslinking procedure. The surfaces of CS-coated Fe3O4 NPs were successfully functionalized with folate-poly(ethyleneglycol)-COOH (FA-PEG) to obtain novel FA-PEG-CS-coated Fe3O4 NPs endowed with long blood circulationand specic targeting capacity. The as-synthesized NPs were characterized by dynamic light scattering, transmissionelectron microscope, X-ray diffraction, thermal gravimetric analysis, vibration sample magnetometer, Fourier transforminfrared spectroscopy, and confocal laser scanning microscopy. As a result, the novel FA-PEG-CS-coated Fe3O4 NPsshowed excellent biocompatibility, magnetic properties, good dispersibility, and proper hydrodynamic sizes in an aqueousmedium. The specific targeting capacity of the as-synthesized NPs to cancer cells was also investigated. It wasobserved that the uptake of the FA-PEG-CS-coated Fe3O4 NPs by HeLa cells was significantly enhanced comparedto the CS-coated Fe3O4 NPs and mPEG-CS-coated Fe3O4 NPs. These results clearly indicate that our novel FA-PEGCS-coated Fe3O4 NPs with remarkable specific targeting capacity, long blood circulation, and superparamagnetismhold great promise for biomedical applications, including targeted drug delivery and hyperthermia therapy.
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