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- 저자 : Shuifan Zhou (검색결과 1 건)
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Shuifan Zhou,Zhenqing Hou,Yang Li,Fei Cui,Mengmeng Jia,Xiangrui Yang,Yange Wang,Liya Xie,Qiqing Zhang 한국고분자학회 2014 Macromolecular Research Vol.22 No.1
The efficacy of magnetic nanoparticles (MNPs) for biomedical applications depends on the specic targetingcapacity, blood circulation time and magnetic susceptibility. Functionalized chitosan-coated Fe3O4 nanoparticles(CS-coated Fe3O4 NPs) were synthesized by a non-solvent-aided coacervation procedure followed by a chemicalcrosslinking procedure. The surfaces of CS-coated Fe3O4 NPs were successfully functionalized with folate-poly(ethyleneglycol)-COOH (FA-PEG) to obtain novel FA-PEG-CS-coated Fe3O4 NPs endowed with long blood circulationand specic targeting capacity. The as-synthesized NPs were characterized by dynamic light scattering, transmissionelectron microscope, X-ray diffraction, thermal gravimetric analysis, vibration sample magnetometer, Fourier transforminfrared spectroscopy, and confocal laser scanning microscopy. As a result, the novel FA-PEG-CS-coated Fe3O4 NPsshowed excellent biocompatibility, magnetic properties, good dispersibility, and proper hydrodynamic sizes in an aqueousmedium. The specific targeting capacity of the as-synthesized NPs to cancer cells was also investigated. It wasobserved that the uptake of the FA-PEG-CS-coated Fe3O4 NPs by HeLa cells was significantly enhanced comparedto the CS-coated Fe3O4 NPs and mPEG-CS-coated Fe3O4 NPs. These results clearly indicate that our novel FA-PEGCS-coated Fe3O4 NPs with remarkable specific targeting capacity, long blood circulation, and superparamagnetismhold great promise for biomedical applications, including targeted drug delivery and hyperthermia therapy.
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