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- 저자 : Lishuang Guo (검색결과 2 건)
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Zhen Fang,Yaowei Liu,Duoxing Yang,Lishuang Guo,Lei Zhang 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.3
We present hydrogen gas concentration data for drilling mud extracted during the Wenchuan Earthquake Fault Scientific Drilling (WFSD; holes 2 and 3), measured on-line during drilling in SW China. Hydrogen influx into the well at depth is largely dependent on lithology and fracture density. In hole WFSD-2, the average background concentration of hydrogen is lower in granitic rocks than in sedimentary formations. More than five major hydrogen influxes were detected while drilling through the sedimentary formations, and two hydrogen-rich zones were detected in the granite (1240–1243 m and 1383.5–1405 m depth). In hole WFSD-3, mud extracted from a tectonic breccia contains high hydrogen concentrations at depths of 600–1000 m depth, and relatively low concentrations below 1000 m depth. In both holes, we observe a lack of hydrogen in the center of the fault zone and high concentrations of hydrogen in fractured zones. Hydrogen concentration in both holes displays significant vertical heterogeneity, and is positively correlated with fracture density. Hydrogen was likely sourced from interaction between water and fresh silicate minerals surfaces that were exposed during faulting, from the mantle, and from faulting events. Fracture zones provide the main channels for the migration of hydrogen gas. The variations in background hydrogen concentrations relate to changes in porosity and permeability. The two hydrogen-rich zones (642.36–676.22 m, and 1383.5–1405 m) were likely caused by earthquake activity or far-field triggering during WFSD-2 drilling. The results of this study provide gas data that can be used to model fault activity. It is important to consider the relationship between hydrogen gas and the seismic cycle, and to use such data to identify seismic precursors.
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Li Shuang,Guo Dongyang,Sun Qiang,Zhang Lu,Cui Yun,Liu Min,Ma Xixi,Liu Yiman,Cui Wenyu,Sun Leimin,Teng Lisong,Wang Liangjing,Lin Aifu,Liu Wei,Zhuo Wei,Zhou Tianhua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo screening and transcriptome profiling followed by quantitative RT-PCR and tissue array analyses, we found that mitogen-activated protein kinase 4 (MAPK4) downregulation in gastric cancer tissues from patients is significantly associated with liver metastasis and poor prognosis. The knockdown of MAPK4 in gastric cancer cells promotes liver metastasis in orthotopic mouse models. MAPK4 depletion in gastric cancer cells induces the secretion of macrophage migration inhibitory factor (MIF) to polarize tumor-associated macrophages (TAMs) in orthotopic xenograft tumors. Moreover, TAMs activate epithelial–mesenchymal transition of gastric cancer cells to suppress MAPK4 expression, which further increases MIF secretion to polarize TAMs. Taken together, our results suggest a previously undescribed positive feedback loop between cancer cells and macrophages mediated by MAPK4 silencing that facilitates gastric cancer liver metastasis.
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