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Liqiang Qi,Bo Sun,Beibei Yang,Su Lu 한국유방암학회 2021 Journal of breast cancer Vol.24 No.5
Purpose Triple-negative breast cancer (TNBC) is a subtype of breast cancer. Increasing evidence supports that dysregulation of long noncoding RNAs (lncRNAs) plays a vital role in cancer progression. RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a lncRNA, is characterized as a tumor-propeller in some cancers, but its mechanism in TNBC remains poorly understood. This study aimed to determine whether and how RMRP functions in TNBC. Methods Cell proliferation was determined by cell counting kit-8 (CCK-8) and colony formation assays and cell apoptosis by flow cytometry analysis and terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) assay. Cell migration and invasion were determined by transwell assays. RNA-binding protein immunoprecipitation (RIP), luciferase reporter, and RNA pulldown assays were implemented to assess the interaction of RMRP with other molecules in TNBC cells. Results RMRP expression was elevated in TNBC cells. RMRP knockdown repressed cell proliferation, migration, and invasion, but induced apoptosis in TNBC. In addition, RMRP was found to target microRNA-766-5p (miR-766-5p) in TNBC cells. Silencing miR-766-5p enhanced cell viability and decreased apoptosis, whereas miR-766-5p overexpression had opposite effects. Furthermore, miR-766-5p was found to bind to yes-associated protein 1 (YAP1). Moreover, miR-766-5p inhibition reversed the repressive effect of RMRP knockdown on the malignant progression of TNBC. Conclusion The present study manifested that RMRP promotes the growth, migration, and invasion of TNBC cells via the miR-766-5p/YAP1 axis. These findings provide novel perspectives for TNBC treatment.
Yang Qian(杨,乾),Li Liqiang(李利强),Zhang Junxiao(张,君孝) 아시아사회과학학회 2022 International Science Research Vol.2 No.1
近年来中国田径在世界大赛中的成绩突飞猛进。剖析近年来中国田径成绩飞速增长的主要原因,整理并研究其训练方法和训练理念,对服务青少年运动日常训练,助推基层青少年田径训练的新路径意义重大。本文通过查阅文献资料逻辑分析等方法,对中国田径取得成绩进行了经验总结,以求为青少年训练获得启示。研究表明:国家队运动员训练目的很明确,注重技术训练、节奏训练;准备活动在训练中占比很大,跟基层训练有着较大的差距,注重训练的细节化;有先进的训练理念,并且不断尝试创新训练。 In recent years, China s track and field achievements in the world championships have made rapid progress. It is of great significance to analyze the main reasons for the rapid growth of China s track and field achievements in recent years, and to sort out and study the training methods and training ideas, so as to serve the daily training of youth sports and boost the new path of track and field training of grassroots youth. This paper summarizes the experience of China s track and field achievements through logical analysis of literature, in order to get enlightenment for youth training. The research shows that: the national team athletes have a very clear training purpose, pay attention to technical training, rhythm training; Preparation activities in the training accounted for a large proportion, with the grassroots training has a large gap, pay attention to the training of the details; Have advanced training concept, and constantly try innovative training.
Xiaoxing Yang,Jiachun Zhou,Liqiang Fan,Zhen Qin,Qiming Chen,Liming Zhao 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.6
Fermented vegetable–fruit beverages are a popular fermented food, with many potential health benefits. In this study, two commercial Lactobacillus plantarum strains were selected to ferment a beverage containing apples, pears, and carrots. The metabolites and antioxidant activities were examined during the fermentation process. Results showed that lactic acid and acetic acid accumulated gradually, whereas malic acid decreased. Glucose and fructose increased from 0.48 and 14.8 g/L to 7.7 and 20.8 g/L, respectively, while sucrose decreased slightly. Ascorbic acid also increased continuously during the fermentation to 90.74 mg/100 mL. DPPH and ABTS radical scavenging activity and FRAP reached their maximum value after 4–8 days. The accumulation of TPC, TFC, and SOD reached their maximum value on the 8th day of fermentation. Our study revealed that the L. plantarum-fermented vegetable–fruit beverage showed significant antioxidant activity, which is helpful in evaluating the fermentation end-point and developing a high-quality fermented beverage.