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- 저자 : Linton, John A. (검색결과 27 건)
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Lichen Planus Is an Uncommon Cause of Nonspecific Proximal Esophageal Inflammation
( Matthew S Linton ),( Liena Zhao ),( Xianyong Gui ),( Martin Storr ),( Christopher N Andrews ) 대한소화기학회 2013 Gut and Liver Vol.7 No.4
Background/Aims: Esophageal lichen planus (LP) has been described as a cause of nonspecific esophagitis that may cause dysphagia, but its incidence is unknown. We aimed to estimate the incidence of esophageal LP in a defined geographic region and describe the clinical characteristics of affected patients. Methods: A histopathology database for a population of 1 million people was searched for all esophageal mucosal biopsy results over an 8-year period. Cases showing inflammation or abnormalities without a diagnosis after three or more biopsies were reviewed for findings of LP. Results: Of 13,589 esophageal biopsies, only one received a diagnosis of LP. Seven patients (four male; mean age, 59 years; range, 39 to 76 years) were identified as having chronic dysphagia and nonspecific proximal esophagitis for which no diagnosis could be made. All patients had proximal inflammation, and six of seven had full-thickness lymphocytic infiltration. Elongation of the lamina propria papillae was noted in all patients, whereas six patients had parakeratosis and ballooning. Only one patient had findings potentially consistent with, but not sufficient for, a diagnosis of esophageal LP. Conclusions: Esophageal LP appears to be extremely uncommon in this North American population, and esophageal biopsy alone is likely not sufficient to establish a diagnosis of LP. (Gut Liver 2013; 7:401-405)
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구급차의 종류 및 주행속도에 따른 흉부압박법의 성공률에 대한 연구
임경수,인요한,황성오 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2
Chest compressions performed in a controlled environment can generate adequate coronary perfusion pressure, but compression is frequently inadequate even when CPR is performed under optimal circumstances, In Korea the average highway of road is narrow and curved more than in other countries, and the back-space in ambulance of Korea is limited to perform CPR. As a result, the CPR in a moving ambulance is no effective in Korea. We studied the effectiveness of chest compression in a moving ambulance by the use of a CPR manikin(Skillmeter Resusci Annie, Laerdal company). The ambulance was driven without a warming siren with obeying all the traffic signals and rules. Eight emergency physicians performed a total of 8 sessions of 2 minutes of continuous chest compression on the manikin in the ambulance(Van-type). They did the same thing in truck-type ambulance. We compared the results between small ambulance(Van type) and large ambulance(Truck type). To compare the effectiveness of manual and mechanical cardiac massage, the mechanical cardiac resuscitator(Thumper: Michigan company) was used. The success rate of manual CPR in a constant speed was not different between the Van-type ambulance and Truck-type ambulance(p>0.05), but mean percentage of correct compression by mechanical chest compressor showed 100%(p=0.004). The success rate of manual CPR in driving at downtown was 67.4± 15.7 in Van-type ambulance, but that was 93.4 ± 5.2 in Truck-type ambulance(p=0.007). These results demonstrate that the performance of manual chest compression in a moving ambulance(Van type) is suboptimal. As the patient care area in the Van-type ambulance is much more spacious than that of the Truck-type ambulance, the diminution of compression efficacy in the smaller ambulance is consistent with the assumption that space is the most important factor in the ability to perform adequate CPR in a moving ambulance. Although the results were good in a truck-type ambulance, chest compression was performed for only 2 minutes. It is difficult for one person to deliver manual chest compression in a moving ambulance for a long period. Mechanical chest compression may be employed where manual compression is technically difficult to perform.
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신혜경,JohnA.Linton,권유진,정요한,Bitna Oh,Sinae Oh 대한가정의학회 2017 Korean Journal of Family Medicine Vol.38 No.6
Background: The gradually increasing demand for coffee worldwide has prompted increased interest in the relationshipbetween coffee and health issues as well as a need for research on metabolic syndrome in adults. Methods: Data from 3,321 subjects (1,268 men and 2,053 women) enrolled in the 2013–2014 Korean NationalHealth and Nutrition Examination Survey were analyzed. The subjects were divided into three groups according totheir daily coffee consumption. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for metabolic syndromein the coffee-drinking groups were calculated using multiple logistic regression analysis by adjusting forconfounding variables. Results: The prevalence of metabolic syndrome was 15.5%, 10.7%, and 9.7% in men and 3.0%, 7.1%, and 6.5% inwomen according to their coffee consumption (less than one, one or two, or more than three cups of coffee perday), respectively. Compared with the non-coffee consumption group, the ORs (95% CIs) for metabolic syndromein the group that consumed more than three cups of coffee was 0.638 (0.328–1.244) for men and 1.344 (0.627–2.881)for women after adjusting for age, body mass index, household income, education, smoking, alcohol, regular exercise,and daily caloric intake. Conclusion: The OR of metabolic syndrome was not statistically significant in both men and women.
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Kim, Jong Im,Linton, Eric W.,Shin, Woongghi The Korean Society of Phycology 2016 ALGAE Vol.31 No.3
The Euglena deses group are common freshwater species composed of E. adhaerens, E. carterae, E. deses, E. mutabilis, and E. satelles. These species are characterized by elongated cylindrical worm-like cell bodies and numerous discoid chloroplasts with a naked pyrenoid. To understand the cryptic diversity, species delimitation and phylogenetic relationships among members of the group, we analyzed morphological data (light and scanning electron microscopy) and molecular data (nuclear small subunit [SSU] and large subunit [LSU] rDNAs and plastid SSU and LSU rDNAs). Bayesian and maximum likelihood analyses based on the combined four-gene dataset resulted in a tree consisting of two major clades within the group. The first clade was composed of two subclades: the E. mutabilis subclade, and the E. satelles, E. carterae, and E. adhaerens subclade. The E. mutabilis subclade was characterized by a lateral canal opening at the anterior end and a single pellicular stria, whereas the E. satelles, E. carterae, and E. adhaerens subclade was characterized by an apical canal opening at the anterior end of the cell and double pellicular striae. The second clade consisted of 20 strains of E. deses, characterizing by a subapical canal opening at the anterior end and double pellicular striae, but they showed cell size variation and high genetic diversity. Species boundaries were tested using a Bayesian multi-locus species delimitation method, resulting in the recognition of five cryptic species within E. deses clade.
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김종임,Eric W. Linton,신웅기 한국조류학회I 2016 ALGAE Vol.31 No.3
The Euglena deses group are common freshwater species composed of E. adhaerens, E. carterae, E. deses, E. mutabilis, and E. satelles. These species are characterized by elongated cylindrical worm-like cell bodies and numerous discoid chloroplasts with a naked pyrenoid. To understand the cryptic diversity, species delimitation and phylogenetic relationships among members of the group, we analyzed morphological data (light and scanning electron microscopy) and molecular data (nuclear small subunit [SSU] and large subunit [LSU] rDNAs and plastid SSU and LSU rDNAs). Bayesian and maximum likelihood analyses based on the combined four-gene dataset resulted in a tree consisting of two major clades within the group. The first clade was composed of two subclades: the E. mutabilis subclade, and the E. satelles, E. carterae, and E. adhaerens subclade. The E. mutabilis subclade was characterized by a lateral canal opening at the anterior end and a single pellicular stria, whereas the E. satelles, E. carterae, and E. adhaerens subclade was characterized by an apical canal opening at the anterior end of the cell and double pellicular striae. The second clade consisted of 20 strains of E. deses, characterizing by a subapical canal opening at the anterior end and double pellicular striae, but they showed cell size variation and high genetic diversity. Species boundaries were tested using a Bayesian multi-locus species delimitation method, resulting in the recognition of five cryptic species within E. deses clade.
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( Alice Unah Lee ),( Heidi Linton ),( Marcia Kilsby ),( David C. Hilmers ) 대한소화기학회 2018 Gut and Liver Vol.12 No.6
Despite the well-proven, safe and effective therapies for hepatitis B infection, delivery of treatment remains a significant challenge in resource-poor settings. Geopolitical and economic restrictions present additional difficulties in providing care in North Korea. However, treatment of patients with chronic hepatitis B remains a top priority for both the North Korean Ministry of Public Health and international agencies working in North Korean hepatitis healthcare facilities. Working in partnership, a path was created to institute this much-needed program. A consortium of United States and Australian humanitarian non-governmental organizations along with generous individual and corporate donors working in concert with local and national health authorities have succeeded in establishing the first hepatitis B treatment program in North Korea. The essential elements of this program include renovation of existing hepatitis hospitals, access to antiviral medications, establishment of laboratory facilities, creation of medical documentation and record-keeping, training of local health care professionals, and quarterly visits by international volunteer physicians and laboratory experts. Management and treatment decisions are made bilaterally. To date, nearly 1,500 patients have been evaluated, and over 800 have been started on long-term antiviral therapy. It is envisioned that this program will eventually be managed and funded by the Democratic People’s Republic of Korea Ministry of Public Health. This program’s success demonstrates a potential model for delivery of antiviral therapy for patients suffering from hepatitis B in other developing countries. (Gut Liver 2018;12:615-622)
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