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RISS 인기검색어
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- 저자 : Lim See Liang (검색결과 2 건)
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Risk factors associated with low anterior resection syndrome: a cross-sectional study
Lim See Liang,Wan Zain Wan Zainira,Zahari Zalina,Zakaria Andee Dzulkarnaen,Hashim Mohd Nizam Md,Wong Michael Pak-Kai,Zakaria Zaidi,Ramely Rosnelifaizur,Sidek Ahmad Shanwani Mohamed 대한대장항문학회 2023 Annals of Coloproctolgy Vol.39 No.5
Purpose: Oncological outcomes following rectal cancer surgery have improved significantly over recent decades with lower recurrences and longer overall survival. However, many of the patients experienced low anterior resection syndrome (LARS). This study identified the prevalence and risk factors associated with the development of LARS. Methods: This cross-sectional study involved patients who were diagnosed with rectal cancer and had undergone sphincter-preserving low anterior resection from January 2011 to December 2020. Upon clinic follow-up, patients were asked to complete an interviewed based questionnaire (LARS score) designed to assess bowel dysfunction after rectal cancer surgery. Results: Out of 76 patients, 25 patients (32.9%) had major LARS, 10 patients (13.2%) had minor LARS, and 41 patients (53.9%) had no LARS. The height of tumor from anal verge showed an association with the development of major LARS (P=0.039). Those patients with less than 8 cm tumor from anal verge had an increased risk of LARS by 3 times compared to those with 8 cm and above (adjusted odds ratio, 3.11; 95% confidence interval, 1.06–9.13). Conclusion: Results from our study show that low tumor height was a significant risk factor that has a negative impact on bowel function after surgery. The high prevalence of LARS emphasizes the need for study regarding risk factors and the importance of understanding the pathophysiology of LARS, in order for us to improve patient bowel function and quality of life after rectal cancer surgery.
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Yang Liang Boo,Helen Siew Yean Ting,Diana Fui Sing Yap,See Guan Toh,Soo Min Lim 대한혈액학회 2019 Blood Research Vol.54 No.3
BackgroundClassical Hodgkin lymphoma (cHL) is a clinicopathologically unique, aggressive lympho-ma arising from germinal center B-cells and is one of the most curable hematological malignancies. This study aimed to determine the clinical course, treatment regimens, re-sponse rates, and survival data of patients diagnosed with cHL in a tertiary center.MethodsA retrospective review was conducted to include patients with a diagnosis of cHL from 2013 to 2017. Data of demographic and clinical characteristics, treatment regimens, and outcomes were collected and analyzed. ResultsWe recruited 94 patients with a median age of 27.0 [interquartile range (IQR), 12] years. Most of the patients were male (61.7%) and 73.4% were ethnic Malay. Nodular sclerosis was the most common histology (77.6%), followed by mixed cellularity (6.4%) and others (16%). The median follow-up time was 28.0 (IQR, 32) months. All patients received che-motherapy but only 13.8% received radiotherapy as consolidation. The doxor-ubicin-bleomycin-vinblastine-dacarbazine regimen was the most common (85.1%), fol-lowed by the escalated bleomycin-etoposide-doxorubicin-cyclophosphamide-vincristine- prednisolone-procarbazine regimen (14.9%). Following treatment, 76.1% of patients achieved complete response. The 2-year overall survival (OS) and progression-free sur-vival (PFS) of the entire cohort were 96.5% and 71.1%, respectively. The 2-year OS and PFS for advanced-stage disease were 93.9% and 62.8%, compared to 100% and 82.7% for early-stage disease, respectively (P=0.252 and P=0.052, respectively).ConclusionThis study provides insight into the clinical presentation and treatment outcomes among patients with cHL in Malaysia. A longer study duration is required to identify OS and PFS benefits and treatment-related complications for different chemotherapeutic regimens.
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