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Affecting factors associated with response of anti-PD-1 therapy in melanoma
( Dokyoung Yoon ),( Donghwi Jang ),( Hyun Jeong Byun ),( Se Jin Oh ),( Youngkyoung Lim ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2
Background: Anti-PD-1 therapy enhances pre-existing immune responses by directly blocking anti-programmed cell death receptor-1. Objectives: To determine the association between dermatologic side effect(SE) and oncologic response of anti-PD-1therapy and to investigate SEs of anti-PD- 1therapy. Methods: We retrospectively reviewed records on patients with melanoma referred to dermatology for skin lesion after treated with pembrolizumab and nivolumab from January 1st, 2015 to April 30th, 2019. To investigate the association between oncologic outcome and dermatologic SE, patients were divided into two groups; good response (complete remission, partial remission), poor response (stable disease, progressive disease). Results: Of 177 patients screened for the study, 14 patients were referred to dermatology with cutaneous SEs. Dermatologic SE includes acneiform eruption, keratoacanthoma, nail change, pruritic eruption, psoriatic eruption, urticarial eruption, and vitiligo. Mean age of all patients with or without dermatologic SE was 58. Though patients who had dermatologic side effect showed higher proportion in good response than that of patients without dermatologic side effect, it was not statistically significant. Conclusion: Various adverse events can occur after anti PD-1 therapy. Dermatologists are supposed to be aware of side-effect profile of the therapy to make sure prompt diagnosis and adequate management.
Lim Sung Hee,Choi Seong Hyeok,Kim Ji Youn,Kim Bora,Kim Han Jo,Kim Se Hyung,Kim Chan Kyu,Park Seong Kyu,Yun Jina 대한의학회 2023 Journal of Korean medical science Vol.38 No.18
Background: A fourth dose of vaccination is known to help reduce the severity and mortality rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The South Korean vaccination guidelines for the fourth dose do not include healthcare workers (HCWs) as priority candidates. We investigated the necessity of the fourth dose in South Korean HCWs based on an 8-month follow-up period after the third vaccination. Methods: Changes in the surrogate virus neutralization test (sVNT) inhibition (%) score were measured at one month, four months and eight months after the third vaccination. The sVNT values were analyzed between infected and uninfected groups, and their trajectories were compared. Results: A total of 43 HCWs were enrolled in this study. In total, 28 cases (65.1%) were confirmed to be infected with SARS-CoV-2 (presumed omicron variant), and all had mild symptoms. Meanwhile, 22 cases (78.6%) were infected within four months of the third dose (median, 97.5 days). Eight months after the third dose, the SARS-CoV-2 (presumed omicron variant)-infected group showed significantly higher sVNT inhibition than that in the uninfected group (91.3% vs. 30.7%; P < 0.001). The antibody response due to hybrid immunity, provided by a combination of infection and vaccination, was maintained at sufficient levels for more than four months. Conclusion: For HCWs who had coronavirus disease 2019 infection after completing a third vaccination, a sufficient antibody response was maintained until eight months after the third dose. The recommendation of the fourth dose may not be prioritized in subjects with hybrid immunity.
Lim, Youn-Mook,Kim, Bo Hae,Kim, Hee-Bok,Park, EunJi,Park, Seok-Won,Park, Jong-Seok,Choi, Se In,Kwon, Tack-Kyun,Kwon, Seong Keun Hindawi Publishing Corporation 2015 BioMed research international Vol.2015 No.-
<P>This study explored a novel strategy to restore the vocal gap by using cross-linked <I>β</I>-glucan hydrogel by <I>γ</I>-irradiation. An aqueous solution of 5 wt% <I>β</I>-glucan was prepared and cross-linked using <SUP>60</SUP>Co <I>γ</I> irradiation. Ten nude mice were injected with 0.8 mL of irradiated <I>β</I>-glucan on the left back and the same volume of nonirradiated <I>β</I>-glucan on the right back for comparison. The mice were sacrificed at 1 and 2 weeks after injection and histological evaluations were performed. Irradiated <I>β</I>-glucan demonstrated a significantly larger volume than nonirradiated <I>β</I>-glucan in the back of nude mice with less inflammatory reaction. After unilateral recurrent laryngeal nerve section in New Zealand White rabbits, irradiated and nonirradiated <I>β</I>-glucan were injected into paralyzed vocal folds. Irradiated <I>β</I>-glucan remained at the paralyzed vocal fold without definite inflammatory signs on endoscopy. High-speed recordings of vocal fold vibration showed decreased vocal gap in irradiated group compared to nonirradiated group. Histologically, the laryngeal epithelium and lamina propria remained intact, without inflammatory cell infiltration. Our newly developed injection material, irradiated <I>β</I>-glucan, showed excellent biocompatibility and remained longer than nonirradiated <I>β</I>-glucan<I> in vivo</I>, suggesting irradiated hydrogels as a new therapeutic approach that may be useful for the long-term treatment of vocal fold palsy.</P>
Se Jin Lim,Hyung-Sun Youn 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.3
Egg allergy has been raised as the most prevalent food hypersensitivity in children. Ovalbumin (OVA), which is one of the major egg allergens, is the major protein in egg white. Isoliquiritigenin (ILG) is an active component present in licorice and has been used to treat many chronic diseases for many years. In this study, we present biochemical evidence that ILG inhibits OVA-induced nuclear factor-κB (NF-κB) activation. ILG also inhibits OVA-induced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression. These data suggest that ILG has anti-allergy effects.
Youn, Young Hoon,Lim, Hyun Chul,Jahng, Jae Hoon,Jang, Sung Il,You, Jung Hwan,Park, Jung Soo,Lee, Se Joon,Lee, Dong Ki Springer US 2011 Digestive diseases and sciences Vol.56 No.5
<P><B>Background</B></P><P>Endoscopic papillary large balloon dilatation (EPLBD) after endoscopic sphincterotomy (EST) has recently become widely used for common bile duct (CBD) stone removal, but many clinicians remain concerned about post-procedural pancreatitis with increasing the balloon size to over 15 mm.</P><P><B>Aims</B></P><P>We aimed to evaluate the safety and efficacy of EPLBD with a relatively large balloon (15–20 mm) after EST and to evaluate the factors related to post-EPLBD pancreatitis.</P><P><B>Methods</B></P><P>A retrospective review was undertaken of the endoscopic database of 101 patients with CBD stones who underwent EPLBD using a larger balloon size of over 15 mm (15–20 mm). Clinical parameters, endoscopic data, and outcomes were analyzed.</P><P><B>Results</B></P><P>The mean age of the subjects was 69 years. All patients had a dilated CBD of over 11 mm (mean = 22.6 mm). The mean size of balloon used in EPLBD was 17.1 ± 1.9 mm (range 15–20 mm). Mechanical lithotripsy was required in seven patients (6.9%). The rate of complete stone removal in the first session was 92.1%. Post-procedural pancreatitis developed in five cases (5.4%), but none were graded as severe. The smaller dilatation of the CBD, longer cannulation time, and longer time for stone removal were associated with post-procedural pancreatitis, but larger size of balloon did not affect the development of post-EPLBD pancreatitis.</P><P><B>Conclusions</B></P><P>EPLBD with a large balloon of over 15 mm with EST is an effective and safe procedure with a very low probability of severe post-procedural pancreatitis. Post-EPLBD pancreatitis was not associated with larger balloon size, but was associated with longer procedure time and smaller dilatation of the CBD.</P>
All-carbon-based cathode for a true high-energy-density Li-O<sub>2</sub> battery
Lim, Hee-Dae,Yun, Young Soo,Cho, Se Youn,Park, Kyu-Young,Song, Min Yeong,Jin, Hyoung-Joon,Kang, Kisuk Elsevier 2017 Carbon Vol.114 No.-
<P>Li-O-2 batteries have a high theoretical energy density; however, their current cathode system based on a heavy metal framework strikingly diminishes their real energy density. Herein, we report the fabrication of all-carbon-based cathodes composed of conventional active carbon and a carbon mesh (CM) framework produced from waste silk fabric by simple pyrolysis. CM frameworks show a high electrical conductivity of similar to 150 S cm(-1), good tensile strength of 34.1 +/- 5.2 MPa, and a Young's modulus of 4.03 +/- 0.7 GPa, as well as a well-ventilated ordered macroporous structure. These all-carbon-based cathodes exhibit stable cycling and high energy densities of similar to 2600 Wh kg(-1) based on total electrode weight, which are 4-15 times higher than those of conventional air cathodes. (C) 2016 Elsevier Ltd. All rights reserved.</P>
Assessment of Breast Cancer Patients' Knowledge and Decisional Conflict Regarding Tamoxifen Use
Kim, Se Ik,Lee, Yumi,Son, Yedong,Jun, So Yeun,Yun, Sooin,Bae, Hyo Sook,Lim, Myong Cheol,Jung, So-Youn,Joo, Jungnam,Lee, Eun Sook The Korean Academy of Medical Sciences 2015 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.30 No.11
<P>Breast cancer is the most common type of female cancer. Tamoxifen, a selective estrogen receptor modulator, is widely used to decrease breast cancer recurrence and mortality among patients. However, it also increases the risk of endometrial cancer. This study aimed to assess knowledge and decisional conflict regarding tamoxifen use. Between June and October 2014, breast cancer patients using tamoxifen were consecutively screened and requested to complete a survey including the EQ-5D, Satisfaction with Decision Scale (SWD), Decisional Conflict Scale (DCS), and a self-developed, 15-item questionnaire measuring tamoxifen-related knowledge. The study sample comprised 299 patients. The mean total knowledge score was 63.4 of a possible 100.0 (range, 13.3-93.3). While 73.9% of the participants knew that tamoxifen reduces the risk of breast cancer recurrence, only 57.9% knew that the drug increases endometrial cancer risk. A higher education level (≥college) was associated with a higher, total knowledge score (β = 4.291; <I>P</I> = 0.017). A higher knowledge score was associated with a decreased DCS score (β = -0.366; <I>P</I> < 0.001). A higher SWD score was also associated with decreased decisional conflict (β = -0.178; <I>P</I> < 0.001). In conclusion, the breast cancer patients with higher levels of tamoxifen-related knowledge showed lower levels of decisional conflict regarding tamoxifen use. Clinicians should provide the exact information about tamoxifen treatment to patients, based on knowledge assessment results, so as to aid patients' decision-making with minimal conflict.</P>
최세윤(Se-Youn Choi),임성무(Sung-Moo Lim),최용훈(Yong-Hun Choi),여인선(In-Seon Yeo) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.11
LED 렌즈의 형상에 따른 배광곡선의 변화를 광학설계 프로그램인 LightTools를 이용하여 분석하였다. 이를 위해 Lambertian 배광의 백색 LED를 모델링 하였으며, 그 위에 실리콘 렌즈를 씌워 배광을 조절하여, 다양한 지향각에 대응하는 렌즈형태를 제시하고자 한다.
상악 및 하악의 전방 분절 절골술을 이용한 안면 프로파일 성형술의 임상적 고찰
백세민,오갑성,윤은성,백롱민,임재호 大韓成形外科學會 1996 Archives of Plastic Surgery Vol.23 No.5
Mid and lower facial convexity is more common in Oriental people than in Caucasian and it is thought to be caused by a more anterior position of dental and skeletal structures rather than soft tissue structures, a more procumbent dentition, and a more acute interincisial angle. To improve their lower facial profile, we performed maxillary and mandibular anterior segmental osteotomies in 96 patients, by way of using palatal mucoperiosteal flap for vascular circulation of the antrior segment and plates and screws for rigid fixation. We also used wafer splint which had been made through model surgery which dental cast and tracing of cephaloghram had been needed. We could get the accurate diagnosis and know how much and which direction the anterior segment should move to get the satisfactory result or improved lower facial profile and corrected occlusal relationship with the teeth. No major complications occurred throughout the followup period except three of over0recessed lip and two of septal deviation, otherwise most of the patients were satisfied with the result.