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- 저자 : Lifang Hou (검색결과 3 건)
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Koutros, Stella,Lynch, Charles F.,Ma, Xiaomei,Lee, Won Jin,Hoppin, Jane A.,Christensen, Carol H.,Andreotti, Gabriella,Freeman, Laura Beane,Rusiecki, Jennifer A.,Hou, Lifang,Sandler, Dale P.,Alavanja, Wiley Subscription Services, Inc., A Wiley Company 2009 International journal of cancer: Journal internati Vol.124 No.5
<P>Imazethapyr, a heterocyclic aromatic amine, is a widely used crop herbicide first registered for use in the United States in 1989. We evaluated cancer incidence among imazethapyr-exposed pesticide applicators enrolled in the Agricultural Health Study (AHS). The AHS is a prospective cohort of 57,311 licensed pesticide applicators in the U.S., enrolled from 1993–1997. Among the 49,398 licensed pesticide applicators eligible for analysis, 20,646 applicators reported use of imazethapyr and 2,907 incident cancers developed through 2004. Imazethapyr exposure was classified by intensity-weighted lifetime exposure days calculated as [years of use × days per year × intensity level]. Poisson regression analysis was used to evaluate the relationship between imazethapyr exposure and cancer incidence. We found significant trends in risk with increasing lifetime exposure for bladder cancer (p for trend 0.01) and colon cancer (p for trend 0.02). Rate ratios (RRs) were increased by 137% for bladder cancer and 78% for colon cancer when the highest exposed were compared to the nonexposed. The excess risk for colon cancer was limited to proximal cancers, (RR = 2.73, 95% confidence intervals 1.42, 5.25, p for trend 0.001). No association was observed for prostate, lung, rectum, kidney, oral, pancreas, lymphohematopoietic cancers or melanoma. These findings provide new evidence that exposure to aromatic amine pesticides may be an overlooked exposure in the etiology of bladder and colon cancer. The use of imazethapyr and other imidazolinone compounds should continue to be evaluated for potential risk to humans. Published 2008 Wiley-Liss, Inc.</P>
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Association of microRNA-3144 variant with the susceptibility to hepatocellular carcinoma
Jun Zhang,Yi Liu,Jie Liu,Rui Wang,Min Cai,Shunji Yu,Yanyun Ma,Weihong Xu,Chunfang Gao,Jiucun Wang,Lifang Hou 한국유전학회 2014 Genes & Genomics Vol.36 No.6
Increasing studies suggest that microRNAs, anew group of small non-coding molecules, regulate theexpression of their target genes and play some roles in cancers. Thus, it is hypothesized that the genetic variants ofmicroRNAs could contribute to the susceptibility to cancers. In this study, the association between rs67106263 in microRNA-3144 and the risk of hepatocellular carcinoma (HCC)was explored in a large-scaled case–control population basedon MassARRAY technology. It was discovered that comparedwith the carriers of wide-type GG genotype and heterozygoteGA genotype of microRNA-3144, thesignificantly increased risk of HCC was observed in thesubjects with the homozygote variant AA (adjusted oddsratio = 1.285, 95 % confidence interval = 1.004–1.643,P = 0.046). Additionally, the variant was also associatedwith the expression of alpha fetoprotein (AFP), which is thediagnostic marker for HCC. Our findings suggest for the firsttime that rs67106263 may play some roles in the risk of HCC,expecting future molecular researches to elucidate the possiblemechanisms behind these results.
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Zhu, Zhong-Zheng,Wang, Dong,Cong, Wen-Ming,Jiang, Hongmei,Yu, Yue,Wen, Bing-Ji,Dong, Hui,Zhang, Xiao,Liu, Shu-Fang,Wang, Ai-Zhong,Zhu, Guanshan,Hou, Lifang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Background: Males have a higher prevalence of hepatocellular carcinoma (HCC) than females in general, but the reasons for the sex disparity are still obscure. DNA copy number alteration (CNA) is a major feature of solid tumors including HCC, but whether CNA plays a role in sex-related differences in HCC development has never been evaluated. Methods: High-resolution array comparative genomic hybridization (CGH) was used to examine 17 female and 46 male HCC patients with chronic hepatitis B virus (HBV) infection in Shanghai, China. Two-tailed Fisher's exact or ${\chi}^2$ tests was used to compare CNAs between females and males. Results: The overall frequencies and patterns of CNAs in female and male cases were similar. However, female HCC tumors presented more copy number gains compared to those in males on 1q21.3-q22 (76.5% vs. 37.0%, P = 0.009), 11q11 (35.3% vs. 0.0%, P = 0.0002) and 19q13.31-q13.32 (23.5% vs. 0.0%, P = 0.004), and loss on 16p11.2 (35.3% vs. 6.5%, P = 0.009). Relative to females, male cases had greater copy number loss on 11q11 (63.0% vs. 17.6%, P = 0.002). Further analyses showed that 11q11 gain correlated with 19q13.31-q13.32 gain (P = 0.042), 11q11 loss (P = 0.011) and 16p11.2 loss (P = 0.033), while 1q21.3-q22 gain correlated with 19q13.31-q13.32 gain (P = 0.046). Conclusions: These findings suggest that CNAs may play a role in sex-related differences in HBVassociated HCC development.
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