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        Separation of the catechol/4-methoxyphenol mixture by stripping crystallization

        Lie-Ding Shiau,Shu-Li Zeng 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.3

        This work presents a novel separation scheme, stripping crystallization (SC), to separate the catechol/4-methoxyphenol mixture. While operated at a triple-point condition, in which the liquid mixture is vaporized and crystallized simultaneously due to the three-phase equilibrium, SC combines distillation and crystallization to produce pure crystals. Experimental results demonstrate the feasibility of applying SC to purify catechol in the catechol/4-methoxyphenol mixture. However, purifying 4-methoxyphenol by SC in the catechol/4-methoxyphenol mixture is rather difficult.

      • KCI등재

        Purification of durene from the mixture of durene and isodurene by stripping crystallization

        Lie-Ding Shiau 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.12

        Stripping crystallization (SC) is introduced in this work to purify durene from the mixture consisting of isodurene and durene. SC is a new technology which combines melt crystallization and vaporization via a series of three-phase transformations at low pressures during the cooling process. The three-phase transformation conditions for a liquid mixture determined by the thermodynamic calculations were adopted to direct the batch SC experiments. A model based on the mass and energy balances was proposed to determine the variation of the amount of remaining liquid, crystallized durene product and produced vapor during SC. The experimental yield and purity of the final durene product obtained from the experiments were compared with those predicted by the model.

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        TiO 2 SUB-MICROSPHERES AS A BI-FUNCTIONAL SCATTERING LAYER FOR HIGH- PERFORMANCE DYE-SENSITIZED SOLAR CELLS

        YONG DING,SONGYUAN DAI,Litao Jia,YANMEI MA,ZHAOQIAN LI,CHANGNENG ZHANG,JIANXI YAO,LIE MO,LINHUA HU,BING ZHANG,LING JIANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.5

        The sub-microspheres play multiple roles in enhancing dye adsorption and light-scattering toimprove the performance of dye-sensitized solar cells (DSSCs). In this work, the well-de¯ned TiO 2sub-microspheres with anatase granular-like nanocrystals are prepared in high yield by com-bining hydrolytic process with solvothermal treatment. Scanning electron microscopy (SEM) andtransmission electron microscopy (TEM) results indicated that plenty of rhombic nanoparticleswith ? 18 nm diameter having mutual contacts to neighboring nanoparticles were densely self-assembled into sub-microspheres, and abundant mesopores existed in the whole sub-microsphereswith superior light scattering ability. The appropriate pore diameter and relatively high speci¯csurface area of the as-obtained sub-microsphere result in a higher dye adsorption. As expected, byusing the sub-microspheres as a scattering layer, a higher photovoltaic conversion e±ciency of10.15% is obtained for DSSCs.

      • SCISCIESCOPUS

        Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle

        Gong, Yingyun,Cao, Rui,Ding, Guolian,Hong, Sungguan,Zhou, Wenjun,Lu, Wenyun,Damle, Manashree,Fang, Bin,Wang, Chuhan C.,Qian, Justin,Lie, Natasha,Lanzillotta, Cristina,Rabinowitz, Joshua D.,Sun, Zheng Elsevier 2018 Molecular and cellular endocrinology Vol.471 No.-

        <P><B>Abstract</B></P> <P>Nuclear receptors regulate gene expression by differentially binding to coactivators or corepressors in a ligand-dependent manner, which further recruits a set of epigenome-modifying enzymes that remodel chromatin conformation. Histone acetylation is a major epigenomic change controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC3 is the only HDAC that confers the enzymatic activity to the complexes nucleated by nuclear receptor corepressors NCoR and SMRT. To address the metabolic function of HDAC3, we have deleted it specifically in mouse skeletal muscles. We have performed the following omics profiling in skeletal muscles of these mice: (1) RNA-seq profiling of total RNA; (2) Global nuclear run-on (GRO-seq) analysis of nascent RNAs; (3) Chromatin immuno-precipitation (ChIP-seq) of HDAC3 at both early evening and early morning; (4) proteomics profiling with mass spectrometry; (5) snap-shot metabolomics profiling of water-soluble metabolites at the basal condition; (6) snap-shot metabolomics profiling of lipid species at the basal condition; (7) kinetic fluxomics analysis of glucose utilization using <SUP>13</SUP>C<SUB>6</SUB>-glucose <I>In vivo</I> during treadmill running exercise. These approaches have provided several novel insights into how nuclear receptors regulate circadian rhythm of skeletal muscle fuel metabolism, which has been published elsewhere. Here we present the original datasets and technical details during the execution, analysis, and interpretation of these omics studies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A mouse model with skeletal muscle-specific KO of HDAC3. </LI> <LI> <I>in vivo</I> RNA-seq, GRO-seq, and ChIP-seq identified relevance to circadian clock. </LI> <LI> Total proteome profiling in muscle samples. </LI> <LI> Metabolomics profiling identified disruption of BCAAs metabolism. </LI> <LI> Fluxomics with <SUP>13</SUP>C-glucose <I>in vivo</I> during treadmill running. </LI> </UL> </P>

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