Research and Application of Collision Detection in Virtual Roam based on WebGL and HTML5

Li Ruizhi,Xu Huahu,Gao Honghao,Yan Yingmin,Bian Minjie,Xu Jiepin 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.11

With the development of the Internet technology, people’s life and work are more and more dependent on the Internet. Remote rendering techniques permit streaming of high-quality 3D graphics to apply onto a wide range of smart devices, and recent years have also seen many solutions of Web3D applications. Web3D is a kind of technology, which can perform the 3D visualization on the Internet, and virtual roam can present information in a far more intuitive and interactive way to people. So, Web3D technology is the foundation of virtual roam technology. Today, Web3D technology and virtual roam technology has become the research focus of computer technology. This paper presents the basic concept and characteristics of Web3D, and designs a solution concerning the virtual roam by combining WebGL and HTML5. This solution has characteristics of good compatibility, GPU acceleration and free plug-ins. Meanwhile, this paper aims at researching collision detection in the virtual roam and presenting a fast collision detection and correction algorithm.

Adaptive Multi-class Support Vector Machine for Microarray Classification and Gene Selection

Juntao Li,Yingmin Jia,Junping Du,Fashan Yu 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

This paper proposes an adaptive multi-classs upport vector machine for simultaneous microarray classification and gene selection. By evaluating the gene ranking significance, the adaptive multi-class support vector machine is shown to encourage an adaptive grouping effect in the process of building classifiers, thus leading as parse multi-classifiers with enhanced interpretability. Based on a reasonablec orrelation between the two regularization parameters, an efficient solution path algorithm is developed for solving the proposed support vector machine. Experiments performed on the leukaemia data set are provided to verify the obtained results.

Error Analysis of PEFP Beam Lines

Ji-Ho Jang,Yingmin Li,Kui Young Kim,Hyeok Jung Kwon,Yong Sub Cho 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.5

This work is related to the error analysis of the proton engineering frontier project (PEFP) beam lines. In order to evaluate the error effects on the trajectory of the beam center, we used an error analysis code that included a first-order perturbation of the translational and the rotational errors of the dipole and the quadrupole magnets in the beam lines. The distorted beam trajectory can be corrected by using corrector magnets. The specifications of the correction dipoles are obtained by using an error correction algorithm that is included in the code. This work is related to the error analysis of the proton engineering frontier project (PEFP) beam lines. In order to evaluate the error effects on the trajectory of the beam center, we used an error analysis code that included a first-order perturbation of the translational and the rotational errors of the dipole and the quadrupole magnets in the beam lines. The distorted beam trajectory can be corrected by using corrector magnets. The specifications of the correction dipoles are obtained by using an error correction algorithm that is included in the code.

Irigenin exerts anticancer effects on human liver cancer cells via induction of mitochondrial apoptosis and cell cycle arrest

Xu Wanggang,Kuang Yingmin,Wang Dan,Li Zhen,Xia Renpin 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1

Irigenin has been reported to exhibit remarkable anticancer effects against several human cancers. Nonetheless, the anticancer effects of irigenin against the human liver cancer cells are still largely unexplored. Consistently, this study was designed to evaluate the anticancer effects of irigenin against human liver cancer cells and to unveil the underlying molecular mechanisms. The results showed that irigenin significantly (p < 0.05) inhibited the growth of the human HepG2 and SNU-182 liver cancer cells with an IC50 value of 14 μM. Nonetheless, the cytotoxic effects of irigenin against the normal THLE-2 cells were comparatively lower as evident from the IC50 of 120 μM. The AO/EB and DAPI staining showed that irigenin induces apoptosis in the human liver cancer cells. Annexin V/PI staining assay revealed a significant (p < 0.05) increase in the percentage of apoptotic HepG2 and SNU-182 liver cancer cells upon treatment with irigenin. It was found that the number of apoptotic HepG2 and SNU-182 cells enhanced from 2.3 to 41.75% and 1.16 to 51.9% at IC50, respectively. Western blot showed a considerable increase in Bax and decrease in the Bcl-2 expression upon irigenin treatment further confirming the induction of apoptosis. Flow cytometric analysis revealed that irigenin also induces G2/M cell cycle arrest of HepG2 and SNU-182 cells. The percentage of G2/M phase HepG2 and SNU-182 cells increased from 17.92 to 34.35% and 23.97 to 38.23% at IC50, respectively This was also accompanied by decrease in the expression of CDK1 and Cyclin-B in HepG2 and SNU-182 cells. Taken together, the results of the present study suggest that irigenin inhibits the growth of the human liver cancer cells via induction of apoptosis and cell cycle arrest. These results point towards the potential of irigenin as a lead for the development of chemotherapy for liver cancer.

Control and Measurement System for the Tuning of a PEFP Low-Beta Superconducting RF Cavity

Zhang Liping,Sun An,Yingmin Li,Tang Yazhe,Yong Sub Cho 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.5

The superconducting RF (SRF) cavity is being considered to accelerate the proton beam in the proton engineering frontier project (PEFP) linac and for its post-project. In order to correct for the frequency shift and the field flatness variation of a TM010 mode in a raw PEFP multi-cell (SRF) cavity caused by manufacturing errors and welding shrinkage during its production, a field flatness tuning system has been developed. A new control and measurement system has been successfully developed for the relevant tuning system. The system automatically controls the bead's forward movement to a designated position and back to its original point and it also drives the network analyzer to measure and acquire the data on the SRF cavity while the bead is moving through the SRF cavity. After the bead has past through the cavity, the control and measurement system provides the cavity's field flatness and the tuning frequencies of the individual cells. The experiments in this study revealed that the control and measurement system is reliable. By using this control and measurement system, the field flatness of a PEFP low-beta cavity can be tuned from 75.62 % at 697.925 MHz to 1.43 % at 700 MHz, which can satisfy the control requirement.

Preparation of Monodisperse Colloidal ZnO Nanoparticles and Their Optical Properties

Chong Yang,Limei Tang,Qingsong Li,Ailing Bai,Yanqiu Wang,Yingmin Yu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.5

Monodisperse colloidal zinc oxide (ZnO) nanospheres with a narrow size distribution were synthesized via a developed two-stage solution method. We controlled the size of the as-synthesized ZnO nanoparticles by varying the amount of ZnO/ethanol suspension added. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) revealed that the diameter of the as-synthesized ZnO nanoparticles was in the range of 60 – 140 nm with a polydispersity index less than 5%. On high-resolution TEM images, we clearly observed that the ZnO nanospheres were actually composed of tiny ZnO subunits, several nanometers in size. Powder X-ray diffraction and TEM-selected area electron diffraction analysis showed that the spheres consisted of polycrystalline nanoparticles. The size of the subunits, which was confirmed by ultraviolet (UV)-visible spectroscopy, increased as the amount of ZnO/ethanol suspension added was decreased. A UV emission at about 374 nm was observed, and this emission of ZnO nanoparticles is found to depend on particle size due to the confinement effect. A red emission at about 651 nm, which has been reported for undoped ZnO, appeared due to the excess oxygen on the particles from O – H or C=O groups. The intensity of the red emission increased as the relative oxygen content increased. The formation mechanism of such ZnO nanospheres was also considered.

Prediction of Cellulose Crystallinity in Liquid Phase Using CBM-GFP Probe

Xiaoyu Guo,Fan Yang,Huixue Liu,Yingmin Hou,Yafang Wang,Jie Sun,Xiaoyi Chen,Yanan Liu,Xianzhen Li 한국고분자학회 2019 Macromolecular Research Vol.27 No.4

Carbohydrate-binding modules (CBMs) have been developed to investigate the presence of crystalline and amorphous regions of cellulose. However, systematic and quantitative assessment of cellulose crystallinity using such non-hydrolytic fusion proteins in liquid phase has not been reported. In this work, cellulose directed CBM probes containing a green fluorescent protein (GFP) were constructed and named CG17, CG28, and CG2a. The probe binding condition was determined as incubating 30 μg/mL probes in 10 mM phosphate buffer at 30oC for 60 min. Under the optimized condition, the linear correlations between CBM probe binding capability and X-ray diffraction (XRD) crystallinity were well established. Using linear regression equations, the crystallinity of several cellulosic materials was well calculated. Amorphous component and cellulosic surface area probably had a less effect on binding capability of CG2a than that of CG17 and CG28. Therefore, crystalline-region specific probe CG2a should be an efficient tool for interpreting the crystallinity of cellulosic materials.

Frequency and Length Adjustment of A PEFP Low-Beta Dumbbell

Changyi, Gao,An, Sun,Liping, Zhang,Yazhe, Tang,Yingmin, Li,Kim, Han-Sung,Cho, Yong-Sub The Korean Society of Superconductivity and Cryoge 2008 한국초전도저온공학회논문지 Vol.10 No.2

Superconducting RF cavities are being considered for accelerating a proton beam at 700 MHz in the linac of the Proton Engineering Frontier Project (PEFP) and its post-project. Dumbbell fabrication is a mid-process for manufacturing an elliptical superconducting RF cavity. During the dumbbell fabrication, control of the dumbbell length and the $TM010\;{\pi}$ mode frequencies is necessary to build up a desired cavity. A new formula with a perturbation measurement method is used to measure and calculate the frequencies of the individual half-cells of a PEFP low-beta dumbbell, and to tune the frequency and length of the half-cells. In this article, the tuning method and results of the PEFP low-beta dumbbells have been presented.

Frequency and Length Adjustment of A PEFP Low-Beta Dumbbell

Gao Chang,Sun An,Zhang Liping,Tang yazhe,Li Yingmin,Han-Sung Kim,Yong-Sub Cho 한국초전도저온학회 (구 한국초전도저온공학회) 2008 한국초전도저온공학회논문지 Vol.10 No.2

KRAS Mutation as a Biomarker for Survival in Patients with Non-Small Cell Lung Cancer, A Meta-Analysis of 12 Randomized Trials

Ying, Min,Zhu, Xiao-Xia,Zhao, Yang,Li, Dian-He,Chen, Long-Hua Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Background: Because there is no clear consensus for the prognostic implication of KRAS mutations in patients with non-small cell lung cancer (NSCLC), we conducted a meta-analysis based on 12 randomized trials to draw a more accurate conclusion. Materials and Methods: A systematic computer search of articles from inception to May 1, 2014 using the PubMed, EMBASE, and Cochrane databases was conducted. The enrollment of articles and extraction of data were independently performed by two authors. Results: Our analysis was based on the endpoints overall survival (OS) and progression-free survival (PFS). Nine records (All for OS, 7 for PFS) comprising 12 randomized trials were identified with 3701 patients who underwent a test for KRAS mutations. In the analysis of the pooled hazard ratios (HRs) for OS (HR: 1.39; 95% confidence interval [CI] 1.23-1.56) and PFS (HR: 1.33; 95% CI 1.17-1.51), we found that KRAS mutations are related to poor survival benefit for NSCLC. According to a subgroup analysis stratified by disease stage and line of therapy, the combined HRs for OS and PFS coincided with the finding that the presence of a KRAS mutation is a dismal prognostic factor. However, the prognostic role of KRAS mutations are not statistically significant in a subgroup analysis of patients treated with chemotherapy in combination with cetuximab based on the endpoints OS (P=0.141) and PFS (P=0.643). Conclusions: Our results indicate that KRAS mutations are associated with inferior survival benefits for NSCLC but not for those treated with chemotherapies integrating cetuximab.