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Shun-Li Wang,Chun-Mei Yu,Carlos Fernandez,Ming-Jie Chen,Gui-Lin Li,Xiao-Han Liu 전력전자학회 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.4
A reduced particle-unscented Kalman filter estimation method, along with a splice-equivalent circuit model, is proposed for the state-of-charge estimation of an aeronautical lithium-ion battery pack. The linearization treatment is not required in this method and only a few sigma data points are used, which reduce the computational requirement of state-of-charge estimation. This method also improves the estimation covariance properties by introducing the equilibrium parameter state of balance for the aeronautical lithium-ion battery pack. In addition, the estimation performance is validated by the experimental results. The proposed state-of-charge estimation method exhibits a root-mean-square error value of 1.42% and a mean error value of 4.96%. This method is insensitive to the parameter variation of the splice-equivalent circuit model, and thus, it plays an important role in the popularization and application of the aeronautical lithium-ion battery pack.
Shun-Feng Cheng,Ling Li,Bo Li,Jing-Cai Liu,Fang-Nong Lai,Yong Zhao,Xi-Feng Zhang,Wei Shen,Lan Li 대한독성 유전단백체 학회 2018 Molecular & cellular toxicology Vol.14 No.2
Backgrounds: Di-(2-ethylhexyl) phthalate (DEHP), as an endocrine-disrupting chemical (EDC), is widely used in plasticizer and other productions. Ubiquitous human exposure to DEHP has been proposed to be a potential risk to public health. Developmental exposure to DEHP could alter epigenetic programming and result in adult-onset disease. Methods: In this study, we investigated whether DEHP exposure to pregnant mice affected epigenetic changes as a result of increase in breast cancer incidence. Results: Our results showed that the expression of total 143 epigenetics-related genes in mammary gland cells, have no significantly altered after short time and low-dose treated with DEHP from 0.5 days post-coitum (dpc) to 3.5 dpc of pregnant mice. DNA methylation status of some neoplastic development genes, such as EGFr, Esr1, Pgr, Fos and Rassf5 also had no obvious change. Conclusion: These finding showed no impact of DEHP on the expressive patterns of epigenetics-related genes and DNA methylation of breast cancer-related genes in pregnant mouse mammary gland cells.
FSCB phosphorylation in mouse spermatozoa capacitation
( Shun Li Liu ),( Bing Ni ),( Xiang Wei Wang ),( Wen Qian Huo ),( Jun Zhang ),( Zhi Qiang Tian ),( Ze Min Huang ),( Yi Tian ),( Jun Tang ),( Yan Hua Zheng ),( Feng Shuo Jin ),( Yan Feng Li ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.8
It is generally accepted that spermatozoa capacitation is associated with protein kinase A-mediated tyrosine phosphorylation. In our previous study, we identified the fibrous sheath CABYR binding protein (FSCB), which was phosphorylated by PKA. However, the phosphorylation status of FSCB protein during spermatozoa capacitation should be further investigated. To this aim, in this study, we found that phosphorylation of this 270-kDa protein occurred as early as 1 min after mouse spermatozoa capacitation, which increased over time and remained stable after 60 min. Immunoprecipitation assays demonstrated that the tyrosine and Ser/Thr phosphorylation of FSCB occurred during spermatozoa capacitation. The extent of phosphorylation and was closely associated with the PKA activity and spermatozoa motility characteristics. FSCB phosphorylation could be induced by PKA agonist DB-cAMP, but was blocked by PKA antagonist H-89.Therefore, FSCB contributes to spermatozoa capacitation in a tyrosine-phosphorylated format, which may help in further elucidating the molecular mechanism of spermatozoa capacitation. [BMB reports 2011; 44(8): 541-546]
Experimental study on axial compressive behavior of hybrid FRP confined concrete columns
Li-Juan Li,Lan Zeng,Shun-De Xu,Yong-Chang Guo 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.4
In this paper, the mechanical property of CFRP, BFRP, GFRP and their hybrid FRP was experimentally studied. The elastic modulus and tensile strength of CFRP, BFRP, GFRP and their hybrid FRP were tested. The experimental results showed that the elastic modulus of hybrid FRP agreed well with the theoretical rule of mixture, which means the property of hybrid composites are linear with the volumes of the corresponding components while the tensile strength did not. The bearing capacity, peak strain, stress-strain relationship of circular concrete columns confined by CFRP, BFRP, GFRP and hybrid FRP subjected to axial compression were recorded. And the confinement effect of hybrid FRP on concrete columns was analyzed. The test results showed that the bearing capacity and ductility of concrete columns were efficiently improved through hybrid FRP confinement. A strength model and a stress-strain relationship model of hybrid FRP confined concrete columns were proposed. The proposed stress-strain model was shown to be capable of providing accurate prediction of the axial compressive strength of hybrid FRP confined concrete compared with Teng et al. (2002) model, Karbhari and Gao (1997) model and Miyachi et al. (1999) model. The modified stress-strain model was also suitable for single FRP confinement cases and it was so concise in form and didn't have piecewise fitting, which would be easy for use in structural design.
miR-200a Inhibits Tumor Proliferation by Targeting AP-2γ in Neuroblastoma Cells
Gao, Shun-Li,Wang, Li-Zhong,Liu, Hai-Ying,Liu, Dan-Li,Xie, Li-Ming,Zhang, Zhi-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Background: MicroRNA-200a (miR-200a) has been reported to regulate tumour progression in several tumours but little is known about its role in neuroblastoma. Our aim was to investigate the potential role and mechanism of miR-200a in neuroblastomas. Materials and Methods: Expression levels of miR-200a in tissues were determined using RT-PCR. The effect of miR-200a and shAP-$2{\gamma}$ on cell viability was evaluated using MTS assays, and target protein expression was determined using Western blotting and RT-PCR. Luciferase reporter plasmids were constructed to confirm direct targeting. Results were reported as mean${\pm}$S.E.M and differences were tested for significance using the 2-tailed Students t-test. Results: We determined that miR-200a expression was significantly lower in neuroblastoma tumors than the adjacent non-cancer tissue. Over-expression of miR-200 are reduced cell viability in neuroblastoma cells and inhibited tumor growth in mouse xenografts. We identified AP-$2{\gamma}$ as a novel target for miR-200a in neuroblastoma cells. Thus miR-200a targets the 3'UTR of AP-$2{\gamma}$ and inhibits its mRNA and protein expression. Furthermore, our result showed that shRNA knockdown of AP-$2{\gamma}$ in neuroblastoma cells results in significant inhibit of cell proliferation and tumor growth in vitro, supporting an oncogenic role of AP-$2{\gamma}$ in neuroblastoma. Conclusions: Our study revealed that miR-200a is a candidate tumor suppressor in neuroblastoma, through direct targeting of AP-$2{\gamma}$. These findings re-enforce the proposal of AP-$2{\gamma}$ as a therapeutic target in neuroblastoma.
Wang, Shun-Li,Yu, Chun-Mei,Fernandez, Carlos,Chen, Ming-Jie,Li, Gui-Lin,Liu, Xiao-Han The Korean Institute of Power Electronics 2018 JOURNAL OF POWER ELECTRONICS Vol.18 No.4
A reduced particle-unscented Kalman filter estimation method, along with a splice-equivalent circuit model, is proposed for the state-of-charge estimation of an aeronautical lithium-ion battery pack. The linearization treatment is not required in this method and only a few sigma data points are used, which reduce the computational requirement of state-of-charge estimation. This method also improves the estimation covariance properties by introducing the equilibrium parameter state of balance for the aeronautical lithium-ion battery pack. In addition, the estimation performance is validated by the experimental results. The proposed state-of-charge estimation method exhibits a root-mean-square error value of 1.42% and a mean error value of 4.96%. This method is insensitive to the parameter variation of the splice-equivalent circuit model, and thus, it plays an important role in the popularization and application of the aeronautical lithium-ion battery pack.
??利(Shun-Li Liu) 중국어문논역학회 2013 中國語文論譯叢刊 Vol.0 No.33
The three envoys on Prince Li Xian tomb’s mural were korean, they were the envoy of Silla, Baekje and Goguryeo. The image of the envoy of Silla liked as the image of one of the famous Silla monk, the monk’name was Yi Xiang. Baekje’s envoy had same clothes style in recording of ancient time in Korean Peninsula. Goguryeo’s envoy stood far away from them, it seems a bit hesitant. Li Xian had been the king of Hebei, who was directly responsible for the foreign affairs of these three countries, so there were three envoys images of Korean Peninsula on his tomb’s mural.
Yuan-yuan Li,Rui-jie Geng,Shun-ying Yu,Guan-jun Li,Zhou-ye Wang,Hua-fang Li 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.10
Objective To investigate the relation between nicotinic acetylcholine receptor subunit (nAChR) genes and schizophrenia, and the relation between tag single nucleotide polymorphism (rs1317286, rs1044396, rs6494212, rs16969968, and rs684513) and schizophrenia in Han Chinese people. Methods The protein-protein interaction (PPI) network among nAChR protein and 350 proteins encoded by schizophrenia-related susceptibility genes was constructed through the String database to explore whether nAChR genes were associated with schizophrenia in these known databases. Then, five single nucleotide polymorphisms (SNPs) of CHRNA3 (rs1317286), CHRNA4 (rs1044396), CHRNA7 (rs6494212), and CHRNA5 (rs16969968, rs684513) were analyzed in a sample of 1,035 schizophrenic patients and 816 healthy controls. The interaction between the markers was analyzed using multifactor dimensionality reduction (MDR) software. Power analysis was performed using the Quanto program. Results There are no significant differences in genotype or allele distribution were identified between the patients and controls (p>0.05). The haplotypes constructed by four markers rs1317286, rs6494212, rs16969968, and rs684513 were not associated with schizophrenia either. However, a significant association between models made of rs1317286, rs1044396, rs6494212, and rs684513 and schizophrenia was revealed in interaction analysis (p<0.05). Conclusion The nAChR protein may have effects on the development of schizophrenia through the interaction with proteins encoded by schizophrenia-related susceptibility genes, but no relation was found between selected polymorphisms and schizophrenia in the collected Han Chinese people. However, interaction analysis suggested four-SNP model has an important effect on schizophrenia.
On the Prediction of Arresting Efficiency of Integral Buckle Arrestors for Deepwater Pipelines
Shun-feng Gong,Gen Li 한국강구조학회 2017 International Journal of Steel Structures Vol.17 No.4
Dedicated finite element models are developed to simulate the crossing of a pipeline integral buckle arrestor by a buckle propagating under the quasi-static, steady-state condition. In addition, broad parametric studies are conducted to identify the mechanism governing the arresting performance, which consider the geometric characteristics and material properties of the pipe and arrestor. Based upon the extensive study, the more reasonable empirical design formulas for the crossover pressure and the arresting efficiency are established by means of the partial fitting. Good agreements between the existing experimental results and the predictions demonstrate that the proposed empirical formula and the lower bound envelope line for the arresting efficiency provide a powerful design tool to estimate the arresting performance of such complex structure systems in engineering practices.