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Topology optimization of irregular flow domain by parametric level set method in unstructured mesh
Li Jiajing,Gao Liang,Ye Mengli,Li Hao,Li Lizhou 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.1
In this study, we present a novel method for the topology optimization of the irregular flow domain using a parametric level set method (PLSM). Some improvement was applied on the CS-RBFs (radial basis functions with compact support)-based PLSM to make it suitable for nonuniform mesh, expanding the range field of engineering application of the PLSM. The optimization problem is solved by a gradient-based algorithm with Stokes equations as state constraints, and the objective is set to minimize the power dissipation subject to the volume constraint of flow channels. A PLSM is introduced to avoid the direct solving of the Hamilton–Jacobi partial differential equation, which can have the potential to break through the restriction of relying on structured meshes because no finite difference scheme is required. Then, a self-adaption support radius approach is presented to allow the parametric level set to be evolved on the nonuniformed mesh, which can expand the application of the PLSM to more complicated engineering problems with irregular geometric shapes. A volume integration scheme is applied during the design sensitivity analysis to calculate the shape derivatives, allowing the nucleation of new holes. Numerical examples in two and three dimensions are provided to demonstrate the effectiveness of the proposed method.
Shuo Li,Lizhou Sun,Guohua Zhou,Huan Huang 한국생물공학회 2015 Biotechnology and Bioprocess Engineering Vol.20 No.6
Early detection of abnormal expression levels of cancer-related genes is crucial for reducing cancer mortality. Here, we describe a dye-free multiplex bioassay for simultaneous and quantitative analysis of the expression levels of multiple genes from one sample in a single assay, based on Sequence-tagged Multiplex ligationdependent probe Amplification (MLPA) coupled with pyrosequencing (termed as “SMAP”). Each pair of MLPA probes, containing a designed barcode, represents a gene of interest; thus, the use of various dyes to label different genes was avoided. The unique three-base barcode design on the probes, which can be decoded by pyrosequencing, enables individual quantification of the expression levels of six genes. Moreover, a new carryover contamination prevention system based on the use of restriction endonucleases was developed for PCR-based diagnostic screening assays. SMAP analysis revealed significant differences between the expression levels of CRC-related genes in the tumor tissues and normal tissues from a CRC patient. For PCR-based diagnostic screening assays, 0.5 U of the FokI restriction endonuclease was sufficient for the removal 0.01 pmol of PCR contamination. The ability to analyze the expression levels of a greater number of cancer-related genes would improve diagnostic sensitivity and efficacy. SMAP is amenable to the detection of an increased number of genes by lengthening the artificially designed barcodes; thus our method provides a promising means for cancer diagnostics and improving the treatment options available to cancer patients.
Li Zhou,Kai Su,Ding-wei Liu,Yin-quan Li,Hong-ze Zhu 국제구조공학회 2023 Structural Engineering and Mechanics, An Int'l Jou Vol.86 No.1
The reinforced concrete lining in the hydraulic pressure tunnel tends to crack during the water-filling process. The lining will be detached from the surrounding rock due to the inner water exosmosis along concrete cracks. From the previous research achievements, the cohesive element is widely adopted to simulate the concrete crack but rarely adopted to simulate the lining-rock interface. In this study, the zero-thickness cohesive element with hydro-mechanical coupling property is not only employed to simulate the traditional concrete crack, but also innovatively introduced to simulate the lining-rock interface. Combined with the indirect-coupled method, the hydro-mechanical coupling algorithm of the reinforced concrete lining in hydraulic pressure tunnels is proposed and implemented in the finite element code ABAQUS. The calculated results reveal the cracking mechanism of the reinforced concrete lining, and match well with the observed engineering phenomenon.
Li, Zhou,Suk, Heung-Il,Shen, Dinggang,Li, Lexin IEEE 2016 IEEE transactions on medical imaging Vol.35 No.8
<P>Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder that has recently seen serious increase in the number of affected subjects. In the last decade, neuroimaging has been shown to be a useful tool to understand AD and its prodromal stage, amnestic mild cognitive impairment (MCI). The majority of AD/MCI studies have focused on disease diagnosis, by formulating the problem as classification with a binary outcome of AD/MCI or healthy controls. There have recently emerged studies that associate image scans with continuous clinical scores that are expected to contain richer information than a binary outcome. However, very few studies aim at modeling multiple clinical scores simultaneously, even though it is commonly conceived that multivariate outcomes provide correlated and complementary information about the disease pathology. In this article, we propose a sparse multi-response tensor regression method to model multiple outcomes jointly as well as to model multiple voxels of an image jointly. The proposed method is particularly useful to both infer clinical scores and thus disease diagnosis, and to identify brain subregions that are highly relevant to the disease outcomes. We conducted experiments on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, and showed that the proposed method enhances the performance and clearly outperforms the competing solutions.</P>
Eco-friendly and Durable Antibacterial Cotton Fabrics Prepared with Polysulfopropylbetaine
Li Zhou,Hongbo Wang,Jinmei Du,Jiajia Fu,Wencong Wang 한국섬유공학회 2018 Fibers and polymers Vol.19 No.6
A novel antibacterial agent polysulfopropylbetaine (PSPB) bearing carboxyl groups was synthesized and its application on cotton fabric to provide durable antibacterial property was also presented. The successful synthesis of PSPB and its immobilization onto the cotton fabric surface were verified by a series of tests including FTIR, 1H NMR, XPS and SEM. Viable cell counting method was employed to investigate antibacterial properties of the finished cotton fabrics. It was found that the cotton fabrics treated with PSPB were endowed with desirable antibacterial activity against both gram-negative bacteria Esherichia coli (E.coli, AATCC 6538) and gram-positive bacteria Staphylococcus aureus (S.aureus, AATCC 25922), with the bacterisotatic rates of 99.69 % and 99.95 %, respectively. Notably, the bacterial reduction rates still maintained over 90 % against both bacteria even after 50 consecutive laundering cycles. Moreover, tests concerning the hydrophilicity, air permeability, water vapor transmission, mechanical properties as well as thermal properties were carried out systematically. The experimental results indicated the hydrophilic performance, air permeability and moisture penetrability of the cotton fabrics finished with PSPB were improved greatly in spite of a slight reduction in thermal performance and little obvious influence on mechanical performance. The antibacterial cotton fabric has the potential to be applied in sportswear, underwear, household textiles, medical fields and much more.