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갑상선암에서 MAGE 1-6 mRNA를 검출하는MAGE common primer의 의의
남철우,최영식,박요한,이강대 고신대학교의과대학 2006 고신대학교 의과대학 학술지 Vol.21 No.2
Background: MAGE (melanoma antigen gene) was named as cancer/testis specific antigens since their expression is only detected in the testis or cancer cells. Because of their relatively specific expression in the cancer cells, they have been considered as the early diagnosis of several cancers, or the appropriate targets for the specific immunotherapy mediated by cytotoxic T lymphocytes. Therefore, there were many reports about the expression of MAGE genes in various types of malignant tumors, but only a few reports in human thyroid neoplasms. The purpose of this study was to determine whether the MAGE common primers expressed in different histological types of thyroid tumors and to see the clinical usefulness of MAGE common primers on the thyroid tumors. Methods: Fifty-nine patients who underwent thyroidectomy at Kosin Medical Center from January, 2001 to April, 2002 were included in the study. Of the 59 patients 40 were papillary carcinoma, 4 follicular carcinoma, 3 medullary carcinoma, 1 anaplastic carcinoma, 4 nodular hyperplasia, 3 adenomatous goiter, and 4 follicular adenoma. Total cellular mRNA was extracted from those 48 cancer tissues, 11 benign tissues and additional eleven normal control thyroid tissues. Nested reverse transcriptase-polymerase chain reactions (nested RT-PCR) with the MAGE common primers designed to detect MAGE 1-6 genes were employed in this study. With probes confirmed by DNA sequencing. Results: Of those 48 cases of thyroid carcinomas 10 cases (20.8%) were expressed MAGE common primers. In the 40 papillary carcinoma, MAGE common primers were expressed in 17.5%. In the four follicular carcinoma, they were expressed in two cases, and in one case of one anaplatic carcinoma. However, in the three cases of medullary carcinoma, MAGE gene was not expressed. None of 11 benign tumors and 11 normal tissues expressed any of these MAGE common primers. The sensitivity of MAGE common primers in thyroid tumors was 20.8% and the specificity was 100%. Conclusion: These results suggested that MAGE common primers were expressed low in the malignant thyroid tumors but it was not expressed in benign tumors and normal tissues. It is suggested that MAGE common primers can be used for preoperative differential diagnosis of follicular carcinoma from benign follicular adenoma which cannot be made by fine needle aspiration cytology of thyroid tissue. However, further study is needed for clinical application of MAGE common primers expression as tumor markers in the thyroid tumors.
당뇨를 동반한 지속외래복막투석 환자에서 발생한 Neisseria sicca 복막염 1예
이혜민 ( Hyae Min Lee ),양인호 ( In Ho Yang ),이선희 ( Sun Hee Lee ),김선혜 ( Seon Hye Kim ),정다운 ( Da Wun Jeong ),정경환 ( Kyung Hwan Jeong ),이상호 ( Sang Ho Lee ),이태원 ( Tae Won Lee ),임천규 ( Chun Gyoo Ihm ),문주영 ( Ju Yo 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.2
Neisseria sicca is a Gram-negative diplococcus found in the human oral mucosa and upper respiratory tract. Although colonization generally does not result in severe infection, some cases of infection have been reported, particularly in immunocompromised individuals. However, Neisseria sicca has not been reported as a pathogen of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis in Korea. Here we describe a case of CAPD-related peritonitis due to Neisseria sicca in a patient with poorly controlled diabetes mellitus undergoing peritoneal dialysis.
千桓旭,洪榮義,金光姚,尹英順,李鉉金 최신의학사 1974 最新醫學 Vol.17 No.11
A clinical analysis were performed on 140 cases of jaundice, including neonates to 15 years of age who were admitted to the Dept. of Pediatrics, Woo Sok Hospital, College of Medicine, Korea Uni?versity during the years from Jan. 1969 to Dec. 1973. The patients were classified by sex ratio, annual distribution annual frequency, incidence of causative diseases and the total serum bilirubin level and sex distribution of causative diseases. The results were revealed as follows; 1. Among the 140 cases, male patients were 92 cases (65.7%) and female 48 cases(34.3%), the ratio of male to female was 1.9 to 1. 2, The frequency of total icteric patients related to total admitted patients during the past 5 years was 4.9%. 3. On annual distribution, 37 cases were in 1972; 30 cases in 1970, 28 cases in 1973;23 cases in 1971;22 cases in 1969 in the order of incidence. 4. On annual frequency, the peak frequency was 6.1% in 1969 and 1970 respectively. 5. The most common causative disease was the infectious hepatitis- revealed 72 cases(51.4%) and the hyperbilirubinemia of 48 cases(34.3%) was the next. 6. The relationship between causative disease and the total serum bilirubinemia, 26 cases(23.2%) of infectious hepatitis were at the level of 2.01-5mg%, and the highest level of one case was 20.1?25 mg%. respectively. 7. The age and sex distribution of causative diseases, the infectious hepatitis was most common and it occured 30 cases(21. 4% ), the sex ratio of male to female was 1. 4 to 1. The hyperbilirubinemia were 29 case(20.7%) within 7 days of age and the sex ratio of male to female was 2.7 to 1.
Urine biomarkers for monitoring acute kidney injury in premature infants
Yo Han Ahn,Juyoung Lee,Ji Young Chun,Yong Hoon Jun,성태정 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.3
Background: Premature infants are at high risk for acute kidney injury (AKI). Serum creatinine (Cr) has limitations for evaluating kidney function in premature infants. We evaluated whether urine biomarkers could be used to monitor AKI in premature infants. Methods: A prospective cohort study was conducted among infants born at < 37 weeks. Urine biomarkers and serum Cr were measured on postnatal days 1, 3, 5, 7, 10, and 14. Infants were divided into 3 groups according to gestational age (GA); < 28, 28 to < 32 and 32 to < 37 weeks. Results: AKI occurred in 17 of 83 (20.5%) recruited infants at a median age of 7 (interquartile range 5–10) days. While the most common cause of AKI was hemodynamically significant patent ductus arteriosus (53.8%) in infants of GA < 28 weeks, necrotizing enterocolitis was the leading cause (50.0%) in infants of GA 28 to < 32 weeks. Urinary levels of neutrophil-gelatinase-associated lipocalin/Cr were higher and epidermal growth factor/Cr were lower in AKI group before the onset of AKI in infants of GA < 28 weeks. In infants of GA 28 to < 32 weeks, urinary interleukin-8/Cr levels were higher in AKI group at approximately the time of AKI onset. Conclusion: Several urine biomarkers were significantly different between AKI and no AKI groups, and some had changed before the onset of AKI. These groups were distinct according to causative factors of AKI and GA. Urine biomarkers could be useful for monitoring the development of AKI in premature infants.