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비타민 E 및 鐵分 早期添加가 新生兒 및 低體重兒 貧血에 미치는 影響
金光姚,崔平和 고려대학교 의과대학 1977 고려대 의대 잡지 Vol.14 No.3
It has been fairly well known that vitamin-E plays a role in hematopoicsis as a supportive factor. The study has been attempted to determine the effects of vitamin-E and iron supplementation on the anemia of infancy and low-birth-weight infants. The measurements of hemoglobin concentration, serum tocopherol levels, reticulocyte count, H₂O₂ hemolysis test were carried out in 78 cases of low-birth-weight infants and 48 cases of normal infants at the age of 1 day, 1 week, 4 weeks and 8 weeks. These infants were divided into 5 groups; the infants of group Ⅰ, Ⅱ, Ⅲ, were weighing less than 2,000g, at birth and Ⅳ and Ⅴ were more than 3,000 g., All infants were fed commercial milk with high linoleic acid. Group Ⅰ (28 cases) and Ⅳ (23 cases) were control, group Ⅱ (25 cases) was added vitamin-E and iron, and groupⅢ(25 cases) and Ⅴ (25 cases) were given vitamin-E. The results obtained were as follows; 1) Infants in group Ⅱ showed significantly lower hemoglobin concentration and higher reticulocyte counts than other groups on the 4th and 8th week of life. 2) All infants receiving the commercial milk gave abnormally high H₂O₂-induced hemolysis and which seems to be decreased by vitamin-E supplementation. 3) Serum tocopherol levels on the 8th week of life showed the lowest level in group Ⅰ (0.6=0.3㎎/100㎖) and there was no significant difference in other groups. It appears that the anemia of low-birth-weight infants who were fed with formula milk was accelerated by early iron supplementation.