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대구지역 야생조류로부터 분리한 Salmonella속 균의 생물화학적 특성과 Plasmid Profile
윤가리,이영주,김기석,탁연빈 한국수의공중보건학회 2003 예방수의학회지 Vol.27 No.2
The present study was conducted to investigate the prevalence, biochemical properties and plasmid profiles of Salmonella organisms isolated from wild birds in Daegu area during the period from May, 1999 to August, 2000. Twenty strains of Salmonella were identified from 192 samples of heron feces and 86 samples of pigeon feces. Among Salmonella isolates, S. montevideo were the most frequent serotype (16 strains), 3 strains of them were S. typhimurium and the other one was untypable. The biochemical properties of 20 strains of Salmonella isolated were in accordance with the traditional characteristics of Salmonella spp. in the majority of biochemical test such as IMViC, carbohydrate fermentation and amino acid decarboxylation. The majority of isolates were highly susceptible to amikacin, ampicillin, amoxicillin, carbenicillin, cephalothin, ciprofloxacine, chloramphenicol, enrofloxacin, furazolidone, gentamicin, kanamycin, nalidixic acid, polymixin B and sulfamethoxazole, while they were moderately susceptible to streptomycin and tetracyclin. However, the majority of them were highly resistant to nitrofurantoin. In plasmid profile, 21.1 kilobase (Kb), 20 Kb and 13.2 Kb fractions were common to three S. tvphimurium and one untypable strains, and no fraction was shown in all strains of S. montevideo.
Ga Yeong Kim,Sang Bin Lee,Ok Kon Moon,Ji Sung Kim,Jung Hyun Choi,Jung San Wang,Joo Hyun Park,Hong Rae Kim,Ju Hwan Lee,Kyung Ok Min 국제물리치료학회 2014 Journal of International Academy of Physical Ther Vol.5 No.2
This study investigated the effects of changes to the pulsation factor of pulsed direct currents on wound healing. Patients with a pressure ulcer at a care hospital for the elderly were randomly divided into three groups: Group 1 involved the application of 100㎲ in pulse duration, 10 ㎳ in pulse period, 100 pps in a pulsation factor, 15 ㎃ in pulse amplitude, and polarity red+ by using pulsed direct currents; Group 2 involved a change of pulse period to 8 ms; and Group 3 received general wound management. Although there were no statistically significant differences in the changing stages of pressure ulcers among the groups, all the groups dropped in numerical stages. In the two groups to which pulsed direct currents were applied, there was a statistically significant reduction in the stages of pressure ulcers from the initial assessment to the 12-week assessment (p<.05). Even though there were no statistically significant differences in changes to the area of pressure ulcers among the groups, a statistically significant decrease was found in pulsed direct current group 2 whose pulse period was shortened (p<.05). There was no difference in the healing rate of pressure ulcers among the groups, but it made a numerical increase in pulsed direct current group 1 and group 2 and a numerical decrease in group 3. There were no significant differences in the characteristics of those who had a full recovery among the groups. Those findings indicate that pulsed direct currents have positive effects on the wound healing of patients with a pressure ulcer and that a treatment with pulsed direct currents whose pulsation factor is raised by reducing the pulse duration is especially effective.
Increased Screening Rates for Thyroid Cancer Among Residents Living Near Nuclear Power Plants
Lee Ga Bin,Park Soojin,Jang Won Il,Park Sunhoo,Jun Jae Kwan,Seo Songwon 대한의학회 2023 Journal of Korean medical science Vol.38 No.44
Frequent screening for thyroid cancer has been suggested as a probable explanation for the observed high risk of thyroid cancer in nuclear power plant (NPP) areas. We aimed to compare thyroid cancer screening rates of residents living near NPPs to those of the general population. This study utilized data from two national survey-based studies in 2016 and in 2014, respectively, for residents (n = 1,200) living in administrative districts within 5 km of NPP sites as the interest group, and the general population (n = 228,712) including distantliving residents (n = 19,100) in administrative districts within 30 km of NPP sites as reference groups. We observed an increase in screening rates in residents near NPPs, which may lead to a higher possibility of thyroid cancer detection. Therefore, further epidemiological studies investigating radiation-induced thyroid cancer risk among residents near NPPs should be carefully designed and interpreted considering possible detection bias.
Lee Ga Bin,Kim Yoonjung,Park Suyeon,Kim Hyeon Chang,Oh Kyungwon 한국역학회 2022 Epidemiology and Health Vol.44 No.-
OBJECTIVES: We investigated trends in obesity, hypertension, diabetes, and hypercholesterolemia before and during the coronavirus disease 2019 (COVID-19) pandemic in the Korean adult population.METHODS: Data from 60,098 participants in the Korea National Health and Nutritional Examination Survey between 2011 and 2020 aged ≥19 were used. The age-standardized prevalence and annual percent changes (APCs) were calculated for obesity (body mass index ≥25 kg/m2), hypertension (systolic/diastolic blood pressure ≥140/90 mmHg or under treatment), diabetes (hemoglobin A1c ≥6.5%, fasting glucose ≥126 mg/dL, physician diagnosis, or under treatment), and hypercholesterolemia (total cholesterol ≥240 mg/dL or under treatment).RESULTS: Over the past decade (2011-2020), the age-standardized APCs (95% confidence intervals) for obesity, hypertension, diabetes and hypercholesterolemia were 3.0% (2.1 to 3.8), 0.1% (-1.3 to 1.5), 1.5% (-1.0 to 4.0) and 8.0% (5.7 to 10.3), respectively, in men; and -0.2% (-1.5 to 1.2), -0.5% (-1.9 to 0.9), -0.1% (-2.3 to 2.2) and 5.9% (3.9 to 8.0), respectively, in women. In 2020 compared to the previous 3 years (2017-2019), obesity, hypertension, diabetes, and hypercholesterolemia increased in men (6.0, 1.8, 1.9, and 2.8%p, respectively), but an increase was not apparent in women (2.5, -1.1, 0.8, and 0.7%p, respectively).CONCLUSIONS: An increase in major chronic diseases was observed in Korean adults, especially men, during the COVID-19 pandemic. In order to reduce the burden of cardiovascular and metabolic diseases in the future, effective intervention strategies need to be developed according to the characteristics of the target groups.
이가빈(Ga Bin Lee),조민호(Min Ho Cho),이형원(Hyeong Won Lee),김낙현(Nak Hyeon Kim) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.6
본 연구에서는 스크러버 내부의 열 유동 수치해석을 수행하였다. 고온의 배기가스와 저온의 세정수의 이상(2-phase)유동을 해석하였으며, 하나의 상이 다른 상에 비해 차지하는 VOF가 10% 미만임을 고려하여 해당 상에 대해 DPM 을 사용하였다. 스크러버는 전처리기와 본처리기의 2단으로 구성되어 있으며 각 처리기 내부의 노즐을 통해 유동장에 세정수가 분사된다. 스크러버의 본처리기 내부의 3단 노즐 위치가 각 단마다 수직, 수평방향으로 어긋나게 배치하여 세정수와 배기가스의 접촉면적을 높임에 따라 배기가스의 냉각이 활발히 진행되도록 설계하였다. 해석 결과로 배기가스의 스크러버의 입구 및 출구 온도를 측정하고 내부 압력 차를 확인하여 선박의 기본 승인을 득할 수 있는 조건을 갖출 수 있는 지 파악하였다. In this study, we performed numerical analysis of heat flow in the scrubber. Analyze the flow of abnormal (2-phase) of hot exhaust gas and cold wash water, and consider that VOF occupies less than 10% compared to one image and others, and put DPM on it. used. The scrubber consists of a preprocessor and two stages of this machine, and wash water is injected into the flow field through the nozzle inside each handler. Exhaust gas cooling is active based on the fact that the position of the three-stage nozzle inside the scrubber"s main handler can be shifted vertically and horizontally for cleaning and the contact area with the exhaust gas is increased. Designed to be done. As a result of the analysis, the temperature of the inlet and outlet of the exhaust gas scrubber was measured, the pressure difference inside was confirmed, and it was understood whether the conditions for basic approval of the ship could be met.
Park, Ga Bin;Kim, Yeong Seok;Lee, Hyun-Kyung;Song, Hyunkeun;Cho, Dae-Ho;Lee, Wang Jae;Hur, Dae Young Sookmyung Women's University Research Institute of 2011 여성과 건강 Vol.6 No.2
CD70 is expressed in normal activated immune cells as well as in several types of tumors. It has been established that anti-CD70 mAb induces complement-dependent death of CD70^+ tumor cells, but how anti-CD70 mAb affects the intrinsic signaling is poorly defined. In this report, we show that ligation of CD70 expressed on EBV-transformed B cells using anti-CD70 mAb induced production of reactive oxygen species (ROS) and subsequent apoptosis. We observed an early expression of endoplasmic reticulum (ER) stress response genes that preceded the release of apoptotic molecules from the mitochondria and the cleavage of caspases. CD70-induced apoptosis was inhibited by pretreatment with the ER stress inhibitor salubrinal, ROS quencher N-acetylcysteine, and Ca^(2+) chelator BAPTA. We supposed that ROS generation might be the first event of CD70-induced apoptosis because N- acetylcysteine blocked increases of ROS and Ca^(2+), but BAPTA did not block ROS generation. We also round that CD70 stimu¬lation activated JNK and p38 MAPK. JNK inhibitor SP600125 and p38 inhibitor SB203580 effectively blocked upregulation of ER stress-related genes and cleavage of caspases. Inhibition of ROS generation completely blocked phosphorylation of JNK and p38 MAPK and induction of ER stress-related genes. Taken together, we concluded that cross-linking of CD70 on EBV-transformed B cells triggered ER stress-mediated apoptosis via ROS generation and JNK and p38 MAPK pathway activation. Our report reveals alternate mechanisms of direct apoptosis through CD70 signaling and provides data supporting CD70 as a viable target for an Ab-based therapy against EBV-related tumors.
Park, Ga Bin,Song, Hyunkeun,Kim, Yeong-Seok,Sung, Minjung,Ryu, Jeoung W.,Lee, Hyun-Kyung,Cho, Dae-Ho,Kim, Daejin,Lee, Wang J.,Hur, Dae Y. Blackwell Publishing Ltd 2009 Immunology Vol.128 No.3
<P>Summary</P><P>B7-H4 is a recently discovered B7 family member that has inhibitory effects on T-cell immunity. However, the reverse signalling mechanism of the B7-H4-expressing cells remains unclear. Previous work has shown that B7-H4 expression was enhanced on B cells following Epstein–Barr virus (EBV) infection, and engagement of cell-surface-expressed B7-H4 induces cell death of EBV-transformed B cells. Here we found that B7-H4 was constitutively expressed on EBV-positive lymphoma cells, Raji and IM-9 cells, but was not expressed on EBV-negative lymphoma cells (Ramos). Engagement of B7-H4 significantly reduced cell growth of Raji and IM-9 cells and resulted in cell cycle arrest at G0–G1 phase in a dose- and time-dependent manner. To clarify the mechanism of cell cycle arrest via activation of B7-H4, cell cycle regulatory factors were examined by reverse transcription–polymerase chain reaction and immunoblotting. We found that B7-H4 triggered down-regulation of CDK4/6 and up-regulation of p21 expression at both protein and RNA levels. Furthermore, CDK2 and cyclin E/D expression was down-regulated by B7-H4 triggering. Additionally, the down-regulation of phospho-AKT and phospho-cyclin E were clearly detected in B7-H4-activated Raji cells, but the phosphorylation of p53 was constitutively maintained. These results indicate that B7-H4-mediated signalling on EBV-positive B-cell lymphoma cells modulates the cell cycle through down-regulation of the AKT pathway. Consequently, B7-H4 may be a new potential target for use in EBV-positive lymphoma therapy.</P>